Navigation Links
Central tolerance


Central tolerance is the mechanism by which newly developing T cells and B cells are rendered non-reactive to self.[1] The process is required due to the random generation of receptor specificities that occurs during T cell and B cell differentiation, whereby a proportion of the cells generated are self-reactive (recognise the component self antigens of the host).

In mammals the process occurs in the thymus (T cells)[2][3] and bone marrow (B cells), when maturing lymphocytes are exposed to self antigens. Self antigens are present in both organs due to endogenous expression within the organ and importation of antigen due to circulation from peripheral sites. In the case of T cell central tolerance, additional sources of antigen are made available in the thymus by the action of the transcription factor AIRE.

After exposure to self antigens, T cells and B cells become immunologically tolerant (non-reactive) in a number of ways :

Genetic defects in these processes lead to autoimmunity, such as in the human syndromes APS-1 and IPEX.

References

  1. ^ http://www-immuno.path.cam.ac.uk/~immuno/part1/lec11/lec11_97.html
  2. ^ Sprent J, Kishimoto H (2001). "The thymus and central tolerance". Philos Trans R Soc Lond B Biol Sci 356 (1409): 609-16. PMID 11375064.
  3. ^ Hogquist K, Baldwin T, Jameson S (2005). "Central tolerance: learning self-control in the thymus". Nat Rev Immunol 5 (10): 772-82. PMID 16200080.
  4. ^ Halverson R, Torres R, Pelanda R (2004). "Receptor editing is the main mechanism of B cell tolerance toward membrane antigens". Nat Immunol 5 (6): 645-50. PMID 15156139.

'"/>


(Date:6/30/2015)... CA (PRWEB) , ... June 30, 2015 , ... ... its new YouTube video, “Fireside Convalescent Care Center.” The video informs community members ... video after continually seeing the need for those seeking care to be well ...
(Date:6/30/2015)... Trenton, NJ (PRWEB) , ... June 30, 2015 , ... ... as one of the first Medicaid Accountable Care Organizations (ACO) in the State, serving ... tomorrow, July 1. , The Trenton Health Team ACO draws on the collaborative structure ...
(Date:6/30/2015)... ... June 30, 2015 , ... The LIV Fertility Center ... preservation and deciding the right age to pursue egg freezing. Statistics show that 20 ... of 35 — a 150 percent increase since the 1970s. , Sadly, for women ...
(Date:6/30/2015)... ... June 30, 2015 , ... Retail ... event and tradeshow, taking place July 29 to August 1. Retail Management Solutions ... ThoughtSpot is a four-day event for independent community pharmacies, where they ...
(Date:6/30/2015)... Terrace, CA (PRWEB) , ... June 30, 2015 ... ... Five-Star Medicare rating in a new video, “Grand Terrace Health Care Center.” Each ... facilities accountable and help patients find the best facility for their needs. Grand ...
Breaking Medicine News(10 mins):Health News:Fireside Convalescent Hospital Proves Itself as a Leading Care Center in New Video 2Health News:Trenton Health Team Certified as Medicaid Accountable Care Organization 2Health News:Trenton Health Team Certified as Medicaid Accountable Care Organization 3Health News:LIV Fertility Center Educating Women on the Critical Timing of Egg Freezing 2Health News:LIV Fertility Center Educating Women on the Critical Timing of Egg Freezing 3Health News:LIV Fertility Center Educating Women on the Critical Timing of Egg Freezing 4Health News:LIV Fertility Center Educating Women on the Critical Timing of Egg Freezing 5Health News:Retail Management Solutions to Attend Amerisource's ThoughtSpot 2015 Conference and Trade Show 2Health News:Retail Management Solutions to Attend Amerisource's ThoughtSpot 2015 Conference and Trade Show 3Health News:Grand Terrace Health Care Center Announces Five-Star Rating in YouTube Video 2
... Ranbaxy Laboratories and Cipla announced an alliance to ... had recently received Drug Controller General of India’s ... a unique dosage form of the broad-spectrum antibiotic. ... be around Rs 310 crore. //,Ciprofloxacin ...
... antioxidants, often as compounds known as flavonoids. It has ... levels of health-promoting flavonoids than apples or orange juice. ... are produced when oxygen burns glucose in cells to ... like DNA and proteins, setting the scene for heart ...
... There are many grueling and expensive options to explore for ... being Acupuncture. ,According to an article from the San ... may have been through the other options. They usually face ... born with a certain number of eggs, hundreds are lost ...
... fruits and vegetables, but don't forget whole grains, if ... disease and cancer, researchers say. Fruits and vegetables especially ... risk by about 32%. , According to a study ... of two to three slices of whole-grain bread each day were ...
... can keep lungs from deteriorating and reduce the risk ... of Ohahio, Dr.Margit Pelkon and collegues investigated the effects ... Finnish participants in four groups:// those who had never ... quit intermittently, and those who had never quit. ...
... the US suggest that acupuncture is at least as ... evidence on the safety of complementary and alternative medicine(CAM). ... of the first serious safety assessments on acupuncture. In ... agreed to record any adverse events occurring between June ...
Cached Medicine News:
Other medicine definitionOther Tags