Navigation Links
Cachexia


Name of Symptom/Sign:
Cachexia
Classifications and external resources
ICD-10 R64
ICD-9 799.4

Cachexia (pronounced [kəˈkɛksiə]) is loss of weight, muscle atrophy, fatigue, weakness and significant loss of appetite in someone who is not actively trying to lose weight. It can be a sign of various underlying disorders; when a patient presents with cachexia, a doctor will generally consider the possibility of cancer, certain infectious diseases (e.g. tuberculosis, AIDS) and some autoimmune disorders. Cachexia physically weakens patients to a state of immobility stemming from loss of appetite, asthenia, and anemia, and response to standard treatment is usually poor.

Contents

Disease settings

Cachexia is often seen in end-stage cancer, and in that context is called "cancer cachexia". It was also prevalent in AIDS patients before the advent of triple-therapy for that condition; now it is seen less frequently in those countries where such treatment is available. In those patients who have Congestive Heart Failure, there is also a cachectic syndrome. Also, a cachexia co-morbidity is seen in patients that have any of the range of illnesses classified as "COPD" (Chronic obstructive pulmonary disease), particularly emphysema.

In each of these settings there is full-body wasting, which hits the skeletal muscle especially hard, resulting in muscle atrophy.

Mechanism

The exact mechanism in which these diseases cause cachexia is poorly understood, but there is probably a role for inflammatory cytokines such as tumor necrosis factor alpha (TNF-α) -which is also nicknamed cachexin for this reason-, Interferon gamma (IFNɣ), and Interleukin 6 (IL-6), as well as the tumor secreted proteolysis inducing factor (PIF).

Related malnutrition syndromes are kwashiorkor and marasmus, although these do not always have an underlying causative illness; they are most often symptomatic of severe malnutrition.

Those suffering from the eating disorder anorexia nervosa appear to have high plasma levels of ghrelin. Ghrelin levels are also high in patients who have cancer-induced cachexia (Garcia et al 2005).

See also

External links


'"/>


(Date:7/3/2015)... ... July 03, 2015 , ... Scientists at several top US ... with even minimal asbestos exposure. Click here to read the complete story , ... Hawaii Cancer Center, Cedars Sinai Medical Center, and New York University exposed mice with ...
(Date:7/3/2015)... ... July 03, 2015 , ... ... providers, has been retained to lead a national chief nursing officer recruitment ... executive search firms in the healthcare industry, B. E. Smith has recently placed ...
(Date:7/3/2015)... ... July 03, 2015 , ... Talcum powder attorneys representing clients in ... Talcum Powder Cancer Lawsuit Center website. Just as the previous version did, the new ... offering timely lawsuit updates and ovarian cancer warning information. The site is routinely updated ...
(Date:7/3/2015)... ... July 03, 2015 , ... " Selfie on a Stick ” was ... and coolest technology products available to consumers. Amanda Forstrom, a technology expert and special ... are great for documenting memories. , Almost every smartphone has an incredibly powerful camera ...
(Date:7/3/2015)... ... July 03, 2015 , ... The Celebrity Dresses is ... dresses similar to those of celebrities will have the opportunity to get 10% discount ... This ensures that people do not have to use coupon codes or remember redemption ...
Breaking Medicine News(10 mins):Health News:Study Finds Small Amounts of Asbestos May Trigger Mesothelioma in People with Genetic Mutation, According to Surviving Mesothelioma 2Health News:Jane Phillips Medical Center Retains B. E. Smith to Recruit New Chief Nursing Officer 2Health News:Jane Phillips Medical Center Retains B. E. Smith to Recruit New Chief Nursing Officer 3Health News:Talcum Powder Lawsuit News: Cancer Attorneys Launch Updated Mobile Site 2Health News:Talcum Powder Lawsuit News: Cancer Attorneys Launch Updated Mobile Site 3Health News:Learn How to Take Selfies like Kendall Jenner 2Health News:Celebrity Fashion Summer Party Dresses on sale at TheCelebrityDresses.com 2
... to control the spread of HIV/AIDS, Dr. Roland M. ... Africa Capacity// Initiative (SACI) of the United Nations Development ... discussion at Stevens Institute of Technology on two topics ... Southern Africa and Opportunities to Stabilize Societies with Information ...
... to alcohol abuse seem to have doubled in Britain over ... show that emergency wards in hospitals, treated twice the number ... drunkenness since 1997. ,Other related medical conditions ... since 1997, accounting for more than a quarter million alcohol ...
... are affected by dengue globally. Dengue is a viral ... shock syndrome is a fatal shock associated// with severe ... any hemorrhage. The pathology of this disease is unknown ... only prevention is vector control. ,This context brought ...
... What is giving researchers a headache is the question ... another form on top of the long-known one! - A ... have solved this controversial puzzle: yes, there is a second ... ,“The two crystalline forms of aspirin are so ...
... appalling to not that slothfulness is on the rise among ... an eye opener//. The study revealed that umpteen teenagers in ... constructive physical activity. They are used to spending time watching ... have increased dramatically in the past five years. ,They ...
... National AIDS Control Organization will be launching a month-long ... Karnataka, Maharashtra, Manipur and Nagaland //focussing on the linkage ... through the mass media including electronic and print. It ... the immunity of the person, easily exposing him to ...
Cached Medicine News:Health News:UN Leader to Deliver Speech Against the Spread of HIV/AIDS 2Health News:First Potential Treatment for Dengue 2Health News:Does Aspirin Crystallize? 2
Other medicine definitionOther Tags