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UW discovery could lead to new TB treatments

MADISON -The family of bacteria that causes tuberculosis (TB) and leprosy are notoriously sturdy. And although the diseases they cause have been held in check for the past 50 years by antibiotics, some strains are becoming increasingly resistant to existing therapy.

Now, however, a new chink has been found in the cellular armor that makes these infectious diseases difficult to treat. The ......

Full article >>> tegrity of its cell walls. Enzymes are proteins that initiate chemical reactions within plant and animal cells.

"We've figured out how this enzyme works. If you knock it out, the bacteria aren't viable," Kiessling explains. "It's an essential enzyme."

The TB microbe's success and resistance to traditional drugs is attributed in large measure to its multilayered cell wall, compose......

Full article >>> orld. It has claimed many notable victims throughout history, including the poet John Keats, composer Frederick Chopin, playwright Anton Chekhov and writers Robert Louis Stevenson, Emily Bronte, D.H. Lawrence and George Orwell.

In addition to Kiessling, the authors of the Nature Structural & Molecular Biology paper include Michelle Soltero-Higgen and Todd D. Gruber of the By WTN News 05/10/04

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