( ignalafter substrate addition (stabl...)Tools for Proteomic Science II

ignal after substrate addition (stable for more than 9 hours).

ELISA

An enzyme-linked immunosorbent assay (ELISA) for biomedical research must be carefully developed and excellently manufactured. ELISAs from Roche Applied Science are designed to be quick and accurate. One-step immunoassays save time and result in less error. Special additives eliminate interference from human anti-mouse antibodies (HAMA). We offer ELISAs for different fields in drug and disease research, such as cytokine and growth-hormone research, oncology research, and others. Moreover, streptavidin-coated microplates (Strepta- Well) with high binding capacity for chemiluminescence, colorimetric, or fluorescence detection are available.

Pathway Analysis

Reporter gene assays

Roche Applied Science offers a broad line of sensitive kits and reagent sets for reporter gene assays on transfected cells. These nonradioactive products measure promotor activity with a sensitivity equal to or greater than that of radioisotopic assays, providing a safe alternative without sacrificing sensitive results.

Apoptosis and cell proliferation

Apoptosis- and cell proliferation-related genes and proteins have become quite relevant putative drug or diagnostic targets since many studies have demonstrated that deregulation of cell death is associated with a variety of diseases. These pathological conditions are accompanied either by cell accumulation (e.g., cancer) or cell loss (e.g., Alzheimers disease). After the identification of a putative target in the proteomics workflow, its function and relevance, as well as the efficacy of specific drugs must be further characterized. For the study of apoptosis- and cell proliferation-related targets, Roc
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