Navigation Links
Tissue Specificity for Mutation Parallels Tissue Specificity for Cancer

g takes place in colon cells.

Ethyleneoxide and Benzene

Sisk et al.7 studied mutation induction in lacI transgenic mice after the mice inhaled 200 ppm of ethylene oxide. The mutant frequency increased significantly in the lung (9.1 x 10-5 versus 6.2 x 10-5 in the controls) but not the spleen, bone marrow, and male germ cells. The lung is indeed a major target organ for tumor formation in the mouse. In another mouse inhalation study with benzene,8 which induces lung tumors, leukemia, and lymphomas, mutations significantly increased in the lung and spleen (a 1.7- and 1.5-fold increase, respectively) but not in the liver tissue. Benzene metabolism takes place partially in the liver, while final oxidation steps can take place in the bone marrow.

Conclusions

The Big Blue transgenic rodent assay system accurately predicts mutations in specific tissues. In a number of cases, mutations are recovered in tissues that are not targets for carcinogenesis. While this eases the screening for mutagenic compounds, it becomes more difficult to determine mutagenic mechanisms and how they relate to carcinogenesis.9 For example, we recently determined that mutation induction in the kidney after TDBP treatment is highest in the cortex layer and less in the outer and inner medulla (de Boer, et al., in preparation). Tumors, however, do not arise in the cortex but in the outer medulla layer. This and other findings indicate that cell proliferation is equally important for tissue-specific tumor formation.

REFERENCES
  1. De Boer, J.G., et al.(1996) Environ. Mol. Mutagen. 28: 418-423.

  2. Mirsalis, J.C., et al.(1993) Mutagenesis 8: 265-271.

  3. Suzuki, T., et al. (1996) Environ. Mol. Mutagen. 28: 348-353.'"/>



Source:


Page: All 1 2 3 4 5 6 7

Related biology technology :

1. Innovative Tissue Array Technology for High-Throughput Screening of Gene Expression
2. Detecting Gastrin-Releasing Peptide Receptor by in situ PCR on Archived Tissue
3. Simple Isolation of RNA from Tissue and Cultured Cells
4. Hands-free Tissue Disruption No Homogenization Needed
5. Recover High Yields of Total Nucleic Acid from Formalin-fixed, Paraffin-embedded (FFPE) Tissue
6. RNase Activity in Mouse Tissue: Classification, Hierarchy, and Methods for Control
7. Stabilizing RNA in Fresh and Frozen Tissues for RNA Isolation
8. Genomic DNA Preparation from RNAlater Preserved Tissues
9. DNA Isolation From 300 to 450 mg Dried or 600 to 1,200 mg Fresh Leaf Tissue
10. DNA Isolation From 50 to 20 mg of Paraffin-Embedded Tissue
11. Genomic DNA Isolation From 510 mg Marine Invertebrate Tissue
Post Your Comments:
(Date:7/31/2015)... -- China Cord Blood Corporation (NYSE: CO) ("CCBC" or ... of cord blood collection, laboratory testing, hematopoietic stem cell ... the Company has filed its Annual Report on Form ... filed Form 20-F includes audited financial statements for the ... can be accessed by visiting the U.S. Securities and ...
(Date:7/30/2015)... ... July 31, 2015 , ... Ralco is honored to announce ... Lyon County Fair to be held August 5-9 in Marshall. The Ralco Enrichment Center ... come from and how agriculture impacts their daily lives. This unique exhibit also features ...
(Date:7/30/2015)... 2015   GenoSpace , a leading provider ... analysis of genomic and other biomedical data, today ... the company as Vice President of Sales and ... "GenoSpace partners with its customers ... and explore complex sets of genomic, phenotypic and ...
(Date:7/30/2015)... Dallas, Texas (PRWEB) , ... July 30, 2015 , ... ... professional and in-depth study on the current state of the global Propanol market with ... are Sinopec, CNPC, BASF, Eastman, Dow, Carboclor, Mitsui Chemicals, Oxea, ISU Chemical, Sanofi, Royal ...
Breaking Biology Technology:China Cord Blood Corporation Files Its Annual Report on Form 20-F 2Ralco Announces Primary Sponsorship of Ralco Enrichment Center at Lyon County Fair 2GenoSpace Introduces Matthew Fischer as Vice President of Sales and Marketing 2Global Propanol Market Technical Data and Manufacturing Analysis 2020 2Global Propanol Market Technical Data and Manufacturing Analysis 2020 3
... Reagents to ... Advance Cancer Research, NEWARK, ... ) -- a leader in providing advanced antibody,products and services ... by Science Applications International Corporation - Frederick,(SAIC-F), to develop monoclonal ...
... 7 at 1:45 PM, DALLAS, April 3, 2008 ... digital health research at ATA 2008 at the,Washington State ... Harry will highlight findings from Private Insurance and ... insurance industry featuring,interviews with twenty senior executives from the ...
... Ratcliff, the,award-winning architecture, planning and interiors firm, master ... tower,accompanied by a 767-stall parking garage and 20,000-square-foot ... Walnut Creek Campus. The Thomas J.,and Muriel T. ... will add,230 private and six semi-private rooms, increasing ...
Cached Biology Technology:Strategic Diagnostics Inc. Selected as Key Supplier to SAIC-F and the National Cancer Institute for the Development of a Comprehensive Portfolio of Antibodies for Use in Cancer Research 2Strategic Diagnostics Inc. Selected as Key Supplier to SAIC-F and the National Cancer Institute for the Development of a Comprehensive Portfolio of Antibodies for Use in Cancer Research 3Parks Associates' Digital Health Analyst to Present Latest Research and Forecasts at ATA Show 2Ratcliff Designs Hospital of the Future for John Muir Medical Center - Walnut Creek Campus 2Ratcliff Designs Hospital of the Future for John Muir Medical Center - Walnut Creek Campus 3
(Date:7/13/2015)... , Jul. 13, 2015 NXT-ID, Inc. ... a biometric authentication company focused on the growing ... filed provisional patent 62/188684 for BEHAVIORAL-DIRECTED ... another new convenient and secure method to make ... innovative payment methods, introduced with its groundbreaking voice-direct ...
(Date:7/8/2015)... 2015 Summary Pancreatic cancer is the ... fatal, with a mortality rate of 10.9 deaths per ... cancer patients has highlighted a significant need for new ... met by the current market. A highly active ... varying molecule types and mechanisms of action, which provides ...
(Date:7/7/2015)... VIEW, Calif. , July 7, 2015 /PRNewswire/ ... biometrics market, Frost & Sullivan recognizes Credence ID, ... Sullivan Entrepreneurial Company of the Year Award. ... suite to aid in its mission of offering ... under-recognized populations globally. As Credence ID was formed ...
Breaking Biology News(10 mins):NXT-ID Patents Behavior-Directed Payments 2NXT-ID Patents Behavior-Directed Payments 3NXT-ID Patents Behavior-Directed Payments 4Frontier Pharma: Pancreatic Cancer - Identifying and Commercializing First-in-Class Innovation 2Frontier Pharma: Pancreatic Cancer - Identifying and Commercializing First-in-Class Innovation 3Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 2Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 3Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 4Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 5
... 2009 issue of the Journal of General Physiology ... University of British Columbia, Vancouver) and colleagues that explores ... using in vivo nonsense suppression technology. The study will ... According to Riccardo Olcese (UCLA) in a commentary accompanying ...
... DURHAM, N.H. Two University of New Hampshire ... (NSF) Faculty Early Career Development (CAREER) grants. Vaughn ... biomedical sciences received $1 million to better understand ... students in data collection. Christopher White of the ...
... Mountain goats are no exception to the general ... healthier offspring. But University of Alberta researcher David Coltman ... mountain goats think twice about their romantic partners. ... taking the eligible females for themselves. The larger males ...
Cached Biology News:2 UNH faculty receive $1.4M in CAREER grants from NSF 2
Standard 2" or 3" Plastic can be ordered with 81 or 100 cell dividers. Mini 2" Plastics Boxes come standard with 25 cell dividers. Plastic boxes can also be ordered with corresponding freezer racks...
Ultra Pure Grade. Used in conjunction with IPTG to identify bacterial colonies that contain recombinant plasmids by blue/white selection. X-Gal forms an intense blue precipitate in the presence of be...
Request Info...
4-Hydroxy-3-nitrophenylacetyl hapten is conjugated to KLH (Keyhole Limpet Hemocyanin) lysine through amide bonds....
Biology Products: