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Tissue Specificity for Mutation Parallels Tissue Specificity for Cancer

sues after carcinogen treatment have addressed whether mutations are induced selectively in those tissues targeted for tumorigenesis. We reviewed some of the available data to illustrate how the Big Blue transgenic rodent mutagenesis assay system is used in tissue-specific studies (Table 1).

Table 1
Induction of Tumors and Mutations in Target and Nontarget Tissues by Selected Carcingens

Compound

Tumor target

Mutations

No mutations

DMN2,3

Liver, kidney, lung

Liver, kidney, lung

Bladder, bone marrow, testis

TDBP1

Kidney

Kidney, liver

Stomach

PhIP*

Colon

Colon

Liver

MeIQ10

Colon, liver, skin, mammary gland

Colon, liver, skin, mammary gland

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Source:


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