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The use of CypHer5E and the IN Cell Analyzer 1000 for live-cell receptor internalization studies

of CypHer5, thereby providing an increased enablement of the dye for monitoring receptors that have reduced epitope availability at the extracellular environment, either due to lower expression levels or trafficking irregularities. These results in conjunction with other data from the IN Cell Analyzer 3000 (laser based platform), demonstrate generic applicability of CypHer5E, not only with respect to cell membrane receptors, but also across a range of microscopy based systems.


References
1. The use of CypHer5 for receptor internalization studies in both a range of GPCRs and a non-GPCR, Amersham Biosciences, 11-0002-80, Edition AA (2004).

2. Screening for beta 2-adrenergic receptor agonists using the pH-sensitive dye, CypHer5, and the IN Cell Analyzer 3000, Amersham Biosciences, 11-0002-81, Edition AA (2004).

3. Pharmacological characterization of beta 2-adrenergic receptor with pH-sensitive dye, CypHer5, and IN Cell Analyzer 3000, Amersham Biosciences, 11-0002-82, Edition AA (2004).

4. Adie, E.J. et al. BioTechniques 33, 1152 (2002).

5. Milligan, G. Drug Discovery Today 8, 579-585 (2003).

6. Oakley, R.H. et al. Journal of Biological Chemistry 274, 32248-32257 (1999).


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