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The let-7 microRNA Family Regulates RAS: Implications for Development and Oncogenesis

om three additional pairs of tissues from lung cancer patients. Western blots were performed using antibodies specific for RAS (US Biological) or GAPDH (Ambion) (top). Northern blot analysis was performed using radiolabeled probes for let-7 and U6 snRNA (middle). NRAS and -actin mRNA, as well as 18S rRNA (for normalization) were quantified by real-time RT-PCR (bottom). Modified with permission from Cell 120: 635647.


This study suggests that let-7 miRNA might function as a tumor suppressor in lung. Misregulation of let-7 might contribute to oncogenesis by triggering up-regulation of RAS protein expression. Analysis of miRNA expression profiles in clinical samples, combined with rapid and powerful loss and gain of function studies in cellular models, will undoubtedly reveal new critical biological functions for members of the miRNA family.


Scientific Contributors
Jaclyn Shingara, Mike Byrom, Rich Jarvis, Angie Cheng, Emmanuel Labourier, Kerri Keiger, Brian Cannon, Vince Pallotta, Sean Banks, David Brown Ambion, Inc.


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