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The Genesis of Gendicine: The Story Behind the First Gene Therapy


In this BioPharm International exclusive interview,SiBionos founder relates the science and manufacture of his companys innovative cancer therapy.



Dr.Zhaohui Peng is the chairman,chief executive officer, and founder of Shenzhen SiBiono GeneTech Co., Ltd.,
Langshen Road, Shenzhen Hi-Tech Industrial Park, Shenzhen, China,
0755.2696.8818,
fax: 0755.2696.8808,
sbn@sibiono.com;www.sibiono.com


In October 2003, Shenzhen SiBiono GeneTech made history by becoming the first company approved to market a gene therapy medication. Chinas State Food and Drug Administration (SFDA) approved Gendicine for treatment of head and neck squamous cell carcinoma (HNSCC). SiBiono believes that continued clinical trials will prove Gendicine to be effective as a widespectrum anticancer agent.

In March, BioPharm International interviewed Dr. Zhaohui Peng, SiBiono's founder, chairman, and CEO, to learn more about the science behind gene therapy, the clinical experience with Gendicine, and the processes involved in manufacturing this ground-breaking new therapy. In addition to a distinguished academic career, Dr. Peng served as director of a research institute at The First Medical University in Guangzhou and as a visiting professor at both the University of Chiba in Japan and the University of California. He also conducted research at two US biotech companies. Dr. Peng has devoted more than ten years to gene therapy research, development, and commercialization.


GENE THERAPY BASICS
BPI: You have used the term adenoviral vector +p53 tumor suppressor-gene delivery system. Will you briefly describe the science
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