Navigation Links
The Affymetrix GeneChip Scanner 3000,,, New Advances in Scanner Design for Superior Performance, Reliability, and Dynamic Range

ents, there is little, if any, difference in data quality when analyzing high-level (highly expressed) signals. Most of the differentiation in data quality is seen when comparing results obtained from analyzing lowlevel signals. The specification used to quantify this property is called Signal-to- Noise Ratio, sometimes abbreviated as S/N Ratio or SNR. Since noise in a practical instrument can approach, but never achieve, zero, there is a finite limit to the lowest level of signal that can, to a reasonable degree of certainty, be measured.

SNR EXAMPLE

The following example is a good way to understand these principles. How accurately can you measure the depth (i.e., Signal) of the ocean at two different locations? The first location is near the shore where the depth is about two feet; the second location is further out where the depth is about one hundred feet. Let us further assume that the water is choppy (Noise) with disturbances of two feet, peak to trough. Exactly how deep is the water when you are standing in two feet of water with two-foot, peak-to-trough waves rolling by? At any instant in time, two-foot waves add about a 50% uncertainty to your measurement accuracy.

Now sail out to water that is 100 feet deep. The same two-foot waves only introduce a 1% uncertainty, relative to the much deeper water. Likewise, the instrument noise-floor is significantly more dominant when measuring small signals versus large signals. The instrumentation noise floor in the GeneChip Scanner 3000 is below the expected biological noise-floor of the array itself.

Reduced Measurement Offset

PREVIOUS SYSTEMS

While noise limits the ability of an electrooptical measurement system to accurately quantify low-level signals, offset reduces the available dynamic range of the system. Offset is the average value returned by the acquisition system with n
'"/>

Source:


Page: All 1 2 3 4 5 6 7 8 9 10

Related biology technology :

1. Fine Tuning Your Data Analysis: Tunable Parameters of the Affymetrix Expression Analysis Statistical Algorithms
2. The New Affymetrix GeneChip Scanner 3000
3. GeneChip Sample Cleanup Module for cleanup of cDNA and in vitro transcribed cRNA
4. New statistical algorithms for Monitoring Gene Expression on GeneChip® Probe Arrays
5. General Notes on Primer Design in PCR*
6. siRNA Design Guidelines
7. Avoid siRNA Design Altogether!
8. Cenix-Designed siRNAs for 95% of Human and Mouse Genomes
9. Designing a Successful qRT-PCR Experiment
10. Designing a Better siRNA
11. Designing Controls for siRNA Experiments
Post Your Comments:
(Date:8/21/2014)... OTC Markets Group Inc. ... company, on its approval to list on The ... the best marketplace for established U.S. and global ... Logo - http://photos.prnewswire.com/prnh/20110118/MM31963LOGO "We ... its growth strategy and achievement of this important ...
(Date:8/21/2014)... August 21, 2014 Pursuit Solutions ... optimization technology and services for Life Sciences sales ... Pharma’s Use of New Commercial Sales Models” by ... Analytics. , The article examines some innovative models ... are being tested in the pharmaceutical market. Robinson ...
(Date:8/21/2014)... Boston, MA (PRWEB) August 21, 2014 ... collaboration company, has been recognized as one of ... 500 | 5000 magazine for the 2nd consecutive ... on its 33rd annual Inc. 500|5000, an exclusive ... list represents the most comprehensive look at the ...
(Date:8/20/2014)... inventions licensed to biotechnology firms has revealed early ... these roadblocks, the researchers suggest that better communication ... could lead to faster commercialization down the road. ... made in university laboratories and licensed to biotechnology ... which have a high failure rate. But a ...
Breaking Biology Technology:OTC Markets Group Congratulates Immune Pharmaceuticals on NASDAQ Listing 2Pursuit's Peter Robinson Publishes "Grading Pharma's Use of New Commercial Sales Models" 2SoundConnect Returns on Inc. 5000 List of Fastest Growing Companies 2SoundConnect Returns on Inc. 5000 List of Fastest Growing Companies 3Early bottlenecks in developing biopharmaceutical products delay commercialization 2Early bottlenecks in developing biopharmaceutical products delay commercialization 3
... Israel, October 15 ,Simbionix USA Corporation is pleased ... of growth capital financing led by River Cities ... and other existing,shareholders, as well as Western Reserve ... investment will enable Simbionix to,accelerate the already rapid ...
... Inc.,(Nasdaq: SUPG ), a pharmaceutical company dedicated ... today announced the company,s plans,to present five posters ... Cancer Therapeutics" on October 23 and 24, 2008., ... advances,in the following compounds: MP-470, SGI-1776 and SGI-1252. ...
... 15 Cepheid (Nasdaq:,CPHD) today announced the ... Xpert(TM) MRSA/SA Skin and Soft Tissue Infection ... Laboratory Improvement Amendments,(CLIA). The new test is ... (MRSA) and Staphylococcus,aureus (SA), (typically Methicillin-sensitive) in ...
Cached Biology Technology:Simbionix Raises Largest Amount in Company's History in Venture Capital to Accelerate Growth 2Simbionix Raises Largest Amount in Company's History in Venture Capital to Accelerate Growth 3SuperGen to Present Data at EORTC-NCI-AACR 2Cepheid Molecular Diagnostic Test for MRSA and S. aureus Categorized 'Moderate Complexity' by FDA 2Cepheid Molecular Diagnostic Test for MRSA and S. aureus Categorized 'Moderate Complexity' by FDA 3Cepheid Molecular Diagnostic Test for MRSA and S. aureus Categorized 'Moderate Complexity' by FDA 4
(Date:8/20/2014)... University, the Wellcome Trust Sanger Institute and the Swiss ... Mycobacterium pinnipedii from skeletons found in Peru which ... a relative of the TB bacterium that affects seals ... researchers assume that seals carried the pathogens from Africa ... was unexpected" comments Sebastien Gagneux, from the Swiss Tropical ...
(Date:8/20/2014)... melanomas the rare type of skin cancer that caused ... other more common types of skin cancer, according to a ... Cell & Melanoma Research . , Acral melanoma most often ... nail-beds and other hairless parts of the skin. Unlike other ... damage from the sun. , The team, from the Cancer ...
(Date:8/20/2014)... synthetic rugs and plastic bags could one day be ... than petroleum, scientists are now reporting. The novel process ... world deal with its agricultural and plastic waste problems, ... Athanassia Athanassiou, Ilker S. Bayer and colleagues at the ... is constantly growing. In 2012, its production reached 288 ...
Breaking Biology News(10 mins):Scientists learn more about rare skin cancer that killed Bob Marley 2
... made of bamboo now stands in Changsha, Hunan Province, China. ... at the USC Viterbi School of Engineering and also a ... Composite Structures of the Hunan University, China designed and constructed ... world. It uses the GluBam technology invented by ...
... A new therapy for metastatic prostate cancer has shown considerable ... become resistant to current drugs. , Of 30 men ... multisite phase I/II trial designed to evaluate safety, 22 showed ... (PSA) in their blood. Phase III clinical trials are planned ...
... As the U.S. Southwest grew warmer between 18,700 and 10,000 ... Mojave Desert, robbing woodrats of their favorite food. Now ... the rodents eat the toxic creosote bushes that replaced junipers. ... biologist Denise Dearing of the University of Utah, lead author ...
Cached Biology News:A full-sized California-style home made of bamboo 2New medications show promise in treating drug-resistant prostate cancer 2New medications show promise in treating drug-resistant prostate cancer 3New medications show promise in treating drug-resistant prostate cancer 4Desert woodrats switch one dietary poison for another 2
... variety of environmental and pathophysiological stressful conditions ... proteins known as heat shock proteins (HSPs), ... (SRPs). The Hsp90 family of proteins ... and beta, Grp94, and Trap-1 (Hsp75). It ...
... (AR) Competitor Assay Kits provide a sensitive ... potential AR ligands using fluorescence polarization (FP). ... domain protein tagged with His and GST ... androgen ligand (Fluormone AL Green in the ...
Custom LNA Oligonucleotide synthesis ,High quality Custom LNA Oligonucleotides are available for a variety of different specialty applications and innovative products. ,Please inquire for further...
... - with a modular approach to instrument ... ChemStation Plus NDS family provides modular software ... data management, giving you the flexibility to ... needs now and that can grow as ...
Biology Products: