Navigation Links
The Affymetrix GeneChip Scanner 3000,,, New Advances in Scanner Design for Superior Performance, Reliability, and Dynamic Range

ents, there is little, if any, difference in data quality when analyzing high-level (highly expressed) signals. Most of the differentiation in data quality is seen when comparing results obtained from analyzing lowlevel signals. The specification used to quantify this property is called Signal-to- Noise Ratio, sometimes abbreviated as S/N Ratio or SNR. Since noise in a practical instrument can approach, but never achieve, zero, there is a finite limit to the lowest level of signal that can, to a reasonable degree of certainty, be measured.

SNR EXAMPLE

The following example is a good way to understand these principles. How accurately can you measure the depth (i.e., Signal) of the ocean at two different locations? The first location is near the shore where the depth is about two feet; the second location is further out where the depth is about one hundred feet. Let us further assume that the water is choppy (Noise) with disturbances of two feet, peak to trough. Exactly how deep is the water when you are standing in two feet of water with two-foot, peak-to-trough waves rolling by? At any instant in time, two-foot waves add about a 50% uncertainty to your measurement accuracy.

Now sail out to water that is 100 feet deep. The same two-foot waves only introduce a 1% uncertainty, relative to the much deeper water. Likewise, the instrument noise-floor is significantly more dominant when measuring small signals versus large signals. The instrumentation noise floor in the GeneChip Scanner 3000 is below the expected biological noise-floor of the array itself.

Reduced Measurement Offset

PREVIOUS SYSTEMS

While noise limits the ability of an electrooptical measurement system to accurately quantify low-level signals, offset reduces the available dynamic range of the system. Offset is the average value returned by the acquisition system with n
'"/>

Source:


Page: All 1 2 3 4 5 6 7 8 9 10

Related biology technology :

1. Fine Tuning Your Data Analysis: Tunable Parameters of the Affymetrix Expression Analysis Statistical Algorithms
2. The New Affymetrix GeneChip Scanner 3000
3. GeneChip Sample Cleanup Module for cleanup of cDNA and in vitro transcribed cRNA
4. New statistical algorithms for Monitoring Gene Expression on GeneChip® Probe Arrays
5. General Notes on Primer Design in PCR*
6. siRNA Design Guidelines
7. Avoid siRNA Design Altogether!
8. Cenix-Designed siRNAs for 95% of Human and Mouse Genomes
9. Designing a Successful qRT-PCR Experiment
10. Designing a Better siRNA
11. Designing Controls for siRNA Experiments
Post Your Comments:
(Date:4/30/2015)... 30, 2015  The Paul G. Allen Family Foundation ... grants to six groups of researchers with projects at ... in neuroscience: growing mature human brain cells in the ... $7.5 million over three years.  "This ... is especially significant because the field of neuronal maturation ...
(Date:4/30/2015)... WuXi PharmaTech (Cayman) Inc. ("WuXi" or the ... R&D services provider, today announced that its board of ... April 29, 2015, from a consortium (the "Consortium") led ... chairman and chief executive officer of the Company, and ... transaction (the "Transaction") involving the acquisition of all outstanding ...
(Date:4/30/2015)... Clinovo Staffing Solutions will represent Clinovo ... in Orlando, FL on May 17-20th, 2015. Trisha Heredia, ... Manager of Staffing Solutions, will present Clinovo’s staffing services ... , “We are excited to be participating in ... Heredia, Senior Director of Staffing Solutions at Clinovo. “PharmaSUG ...
(Date:4/29/2015)... GUELPH, ON , April 29, 2015 /PRNewswire/ - BIOREM Inc. (TSX-V: BRM) ... twelve-month periods ended December 31, 2014. Biorem,s complete fiscal 2014 year-end financial ... FINANCIAL HIGHLIGHTS: 2014 , 2013 , 2014 ... 10,683 , 19,596 Gross profit 1,326 , ... 1,191 , 1,493 , 3,377 , ...
Breaking Biology Technology:The Paul G. Allen Family Foundation Awards $7.5 Million To Study Brain Cell Growth And Development 2The Paul G. Allen Family Foundation Awards $7.5 Million To Study Brain Cell Growth And Development 3The Paul G. Allen Family Foundation Awards $7.5 Million To Study Brain Cell Growth And Development 4The Paul G. Allen Family Foundation Awards $7.5 Million To Study Brain Cell Growth And Development 5WuXi PharmaTech Announces Receipt of Proposal 2WuXi PharmaTech Announces Receipt of Proposal 3WuXi PharmaTech Announces Receipt of Proposal 4WuXi PharmaTech Announces Receipt of Proposal 5WuXi PharmaTech Announces Receipt of Proposal 6Clinovo Exhibits at the 2015 PharmaSUG Annual Conference on May 17-20th in Orlando, FL 2Clinovo Exhibits at the 2015 PharmaSUG Annual Conference on May 17-20th in Orlando, FL 3Biorem Reports Results for Fourth Quarter 2014 and Year Ended December 31, 2014 2Biorem Reports Results for Fourth Quarter 2014 and Year Ended December 31, 2014 3Biorem Reports Results for Fourth Quarter 2014 and Year Ended December 31, 2014 4
... help manufactures manage some of the most complex, ... the world. The company will now offer Boston-based ... save millions of dollars with improved supply chain ... customers who choose to optimize inventories and improve ...
... differential between U.S. white collar workers and those in India ... , ,IT Manager ,U.S: $55,000 ,India: $8,500 , ,Accountant ,U.S.: ... United States were almost solely in the manufacturing sector, as ... or other Latin American countries to cut costs. Not to ...
... like something from a futuristic movie. But Plexus, ... Neenah, Wis., is making those futuristic dreams a ... manufacturer of fingerprint sensors. , ,Plexus announced the ... integration services for AuthenTec's TruePrint technology-based fingerprint sensors. ...
Cached Biology Technology:Schneider Logistics Helps Manufacturers Secure Competitive Advantage 2Outsourcing Offshore - Wisconsin Companies Sending Work Abroad 2Outsourcing Offshore - Wisconsin Companies Sending Work Abroad 3Plexus Partnering with AuthenTec 2
(Date:4/14/2015)... Conn. , April 14, 2015 NXT-ID, ... a biometric authentication company focused on the growing mobile ... been nominated for the 2015 New York Design Awards ... The Design100, New York City Design Awards are part ... based on over 2,500 ratings from the marketplace, industry ...
(Date:4/9/2015)... , April 9, 2015 Synaptics Inc. (NASDAQ: ... solutions, announced today that it will report financial results ... April 23, 2015, after the close of market. The ... and investors at 2:00 p.m. PT (5:00 p.m. ET), ... To participate on the live call, analysts and ...
(Date:4/2/2015)... , April 2, 2015 At its 2015 ... Lake City , the American College of Medical ... new directors to its Board.  Members of the ACMG ... and for forming and advancing its policies and programs. ... profession. "It,s an eventful time in medical ...
Breaking Biology News(10 mins):NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3Synaptics to Report Third Quarter Results on April 23 2American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 2American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 3American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 4American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 5American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 6American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 7American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 8
... Colo., USA - The February 2014 Lithosphere ... travertine in the Rio Grande rift, central New Mexico; ... Australia; the first lithosphere-scale illustration of the structural evolution ... formation; evaluation of the central Garlock fault in Pilot ...
... David Allis, a pioneer in the field of epigenetics whose ... role in regulating the activity of individual genes, will be ... by the Japan Prize Foundation, was made at a press ... approximately half a million dollars, is among the most prestigious ...
... Institute,s Illinois Natural History Survey have found that overall, concentrations ... from the lower Illinois River do not appear to be ... The full results of the study have been published in ... mercury concentration in fillets was below the US Food and ...
Cached Biology News:Rio Grande fift, Rum Jungle complex, Black Sea, West Africa craton, California faults 2Rio Grande fift, Rum Jungle complex, Black Sea, West Africa craton, California faults 3Rio Grande fift, Rum Jungle complex, Black Sea, West Africa craton, California faults 4Rio Grande fift, Rum Jungle complex, Black Sea, West Africa craton, California faults 5David Allis, pioneer in epigenetics, to receive prestigious Japan Prize 2Research shows arsenic, mercury and selenium in Asian carp not a health concern to most 2
...
... Mouse monoclonal [RS17 ] to PRKAR2 ... a variety of cellular functions. cAMP exerts ... kinase (AMPK), which transduces the signal through ... holoenzyme of AMPK is a tetramer composed ...
...
... a Perkin Elmer UltraVIEW system and want to ... and iQ software? No problem. Our experienced ... your existing microscope, lasers, Sutter filter wheel, Piezo ... work with our precision controller unit and workstation... ...
Biology Products: