Navigation Links
Speciation of Arsenic by LC-ICP-MS

Michael Leist Varian

Analytical Instruments Mulgrave, Victoria 3170, Australia E-mail: icpms@varianinc.com

Introduction

As toxicity, mobility, and bioavailability can differ greatly between the various chemical species in which an element occurs, reporting only the total concentrations can often be misleading. Arsenic is one such example where the various species differ; the inorganic trivalent form (As III) is the most toxic, followed by the inorganic pentavalent form (As V). Other common forms of arsenic include monomethyl arsenic (MMA), dimethyl arsenic (DMA) and arsenobetaine (AsB), which have signifi cantly reduced toxicities. Therefore, separation and detection of these species can greatly assist risk-based toxicity assessments.

When Liquid Chromatography (LC) is interfaced with Inductively Coupled Plasma Mass Spectrometry (ICP-MS), species elute one by one from the LC column directly to the ICP-MS for detection by elemental speciation. The coupling of LC to ICP-MS is a straight forward task; the LC column is connected to the nebulizer of the ICP-MS by a piece of PEEK tubing, and no hardware changes are required to either the LC or the ICP-MS. Coupling an LC to a Varian ICP-MS has the added advantage of offering high sensitivity, with over 80% of the analyte ions passing through the skimmer cone being transferred to the quadrupole1. The Varian ICP-MS, with its patented 90 degree ion mirror2, is the worlds fi rst ICP-MS with tunable gigahertz sensitivity.

The following experiment shows the sensitivity and detection capabilities of the high sensitivity Varian ICP-MS for element speciation.

Experimental

Instrumentation

A schematic of the overall system is shown in Figure 1.

The LC system used was a Varian ProStar 230 Tertiary Solvent Delivery Module,
'"/>

Source:


Page: All 1 2 3 4 5

Related biology technology :

1. A Positive Selection Assay for Mutation Analysis in Big Blue Animals
2. Epitope-Tagging Vectors for Functional Analysis in Yeast
3. Map and Link Human Genetic Disorders with SSLP Analysis
4. CastAway Precast Gels for Rapid Automated DNA Sequence Analysis
5. Single-cell RT-PCR Analysis of Paramecium Primaurelia with the Eppendorf cMaster RTplusPCR System
6. Structural Analysis of Glycosylated Peptides in Complex Mixtures with Ion Trap MSn
7. Use of Transcriptor Reverse Transcriptase in Microarray Analysis
8. Increased Sensitivity in Microarray Analysis
9. Gene-Expression Analysis of TP, DPD, and TS Using the LightCycler mRNA Quantification KitsPLUS
10. Agilent 2100 Bioanalyzer Automated Analysis System
11. Analysis of Microarray Data
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Speciation Arsenic ICP

(Date:7/25/2014)... Pa. , July 25, 2014 /PRNewswire-iReach/ -- ... and consulting for global corporations operating in highly ... host its first annual Global User Group Conference, ... historic Philadelphia, Pennsylvania at ... - http://photos.prnewswire.com/prnh/20140724/130263 This ...
(Date:7/24/2014)... 2014 Gain recognition for leadership ... of the biotech industry. Nominations are now being ... to you by the Bio Supply Management ... chain management professionals for the past 7 years. ... the Biotech industry – Manufacturers, Service Providers, Material ...
(Date:7/24/2014)... A research team led by group leader Yung-Eun ... technology to synthesize sulfur-doped and nitrogen-doped graphenes which ... secondary batteries and fuel cells. Yung-Eun Sung is ... Nanoparticle Research at Institute for Basic Science* (IBS) ... , This achievement has great significance with regards ...
(Date:7/24/2014)... July 24, 2014 Research and Markets ... Genomics and Proteomics Analytical Instruments Market 2014-2018" report ... Genomics is the study of the ... of the structure and functions of proteomes or sets ... and technology. Genomics involves the mapping of genes and ...
Breaking Biology Technology:Xybion Announces It Will Host International User Conference in Philadelphia 2Xybion Announces It Will Host International User Conference in Philadelphia 3Call for Submission: BSMA’s Supply Chain Management Innovation Awards 2Call for Submission: BSMA’s Supply Chain Management Innovation Awards 3Global Genomics and Proteomics Analytical Instruments Market 2014-2018: Key Vendors are Agilent, Bio-Rad , F. Hoffmann, La Roche, Illumina, PerkinElmer and Thermo Fisher Scientific 2
... Sept. 7 Alba Therapeutics Corporation today,announced the ... Senior Vice,President, Clinical Development and Medical Affairs. In ... leading Alba,s clinical development strategy,and program execution through ... serve as a member of Alba,s executive management,leadership ...
... - ARIUS Research Inc., (TSX:,ARI), a biotechnology company ... today announced that it will deliver poster,presentations at ... its anti-cancer antibody drug candidates. At the ... September 7-8,Arius will report recent results of its ...
... 1959, Nobel Prize winner Richard Feynman presented a talk entitled ... that there was no physical reason why humans couldn,t manipulate ... of observing the new atom positions remains. How do ... the Sept. 7, 2007 issue of Science, IBM and Imago ...
Cached Biology Technology:Alba Therapeutics Appoints Dr. Betsy Van Parijs as Its Senior Vice President, Clinical Development and Medical Affairs 2Arius Features Preclinical Data on Antibody Candidates at Two Conferences 2Arius Features Preclinical Data on Antibody Candidates at Two Conferences 3IBM and Imago find a crucial difficulty in semiconductor device scaling 2
(Date:7/25/2014)... CORAL SPRINGS, Florida , July 25, 2014 /PRNewswire/ ... influential as more consumers are turning to digital technology ... NXT-ID, Inc. (OTCBB: NXTD), Google Inc. (NASDAQ: ... Visa Inc. (NYSE: V ), Apple Inc. ... FTNT) NXT-ID, Inc., (OTCQB: NXTD) a biometric ...
(Date:7/24/2014)... , July 24, 2014 /PRNewswire-iReach/ -- The Geneva Healthcare ... cardiac devices, has cut emergency room wait times by ... Diego (UCSD) Medical Center, according to a recent study ... Emergency Departments are using the suite to access data ... or defibrillators. "Using Geneva,s technology platform we ...
(Date:7/24/2014)... disturbance has different effects on different species of ... Universities of Bristol and Exeter which tested fish ... to a flying seagull predator model when exposed ... in European minnows. , Lead author Dr ... said: "Noise levels in many aquatic environments have ...
Breaking Biology News(10 mins):Consumer Needs for Identity Theft Security Grows with Popularity of Latest Smart Technology Products - Biometrically Secure Digital Wallet to Replace Credit Card Dependency 2Consumer Needs for Identity Theft Security Grows with Popularity of Latest Smart Technology Products - Biometrically Secure Digital Wallet to Replace Credit Card Dependency 3Consumer Needs for Identity Theft Security Grows with Popularity of Latest Smart Technology Products - Biometrically Secure Digital Wallet to Replace Credit Card Dependency 4Consumer Needs for Identity Theft Security Grows with Popularity of Latest Smart Technology Products - Biometrically Secure Digital Wallet to Replace Credit Card Dependency 5Consumer Needs for Identity Theft Security Grows with Popularity of Latest Smart Technology Products - Biometrically Secure Digital Wallet to Replace Credit Card Dependency 6UC San Diego Medical Center Cuts Average ER Wait Time by 92 Minutes using the Geneva Healthcare Suite 2UC San Diego Medical Center Cuts Average ER Wait Time by 92 Minutes using the Geneva Healthcare Suite 3
... receive a special discretionary prize, as part of the ... The European Molecular Biology Organization (EMBO) awards the prize ... communication with the public. The additional award was made ... a single organism using all available media. , ...
... Barbara, Calif.) It,s no secret that humans are having ... animals. UC Santa Barbara,s Steven D. Gaines and fellow researcher ... world,s far-flung islands. Their research, published this month in ... sheds surprising light on the subject of extinction rates of ...
... Organization (EMBO) announced that the German evolutionary biologist Axel ... the 2008 EMBO Award for Communication in the Life ... scientist in Europe for outstanding communication with the public. ... continuous endeavour to convey complex scientific topics to the ...
Cached Biology News:EMBO recognizes German zoologist for public communication 2Study of islands reveals surprising extinction results 2Study of islands reveals surprising extinction results 3Prominent German biologist wins EMBO Communication Award 2
... The excellent isocratic refractive index chromatography system, ... CE 4700. Data processing is provided ... delivery is by the high pressure CE 4100 ... can be supplied. The system can ...
...
Mouse monoclonal antibody to QPCT - glutaminyl-peptide cyclotransferase (glutaminyl cyclase)...
...
Biology Products: