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Simultaneous Screening of 23 Drugs of Abuse in Oral Fluid Using an LC/MS/MS Method

is for determining whether or not a sample has been adulterated. For example, screening for methadone metabolites could establish if methadone had actually been taken or merely added to the sample prior to analysis.

Interpretation of Results Using the Analyst software, numerical results can be generated and results tables can be customized for easy interpretation and use. A typical results table, generated using a single point calibrator at the cut-off level, is shown in Figure 6. This table provides the analyst with immediate information as to whether the levels detected in the samples are above or below the accepted cut-off levels.*

* Refers to cut-off levels at time of going to press.

Conclusions

The LC/MS/MS method described here provides a rapid, simple and reliable test to detect 23 drugs of abuse in oral fluid. Based on the results of this study:

This method has potential as a fully quantitative testing method in research and forensic applications.

The method can be used to ascertain whether the detected level is above or below an established cut-off value, giving a simple yes/no test in the style of commercially available immunoassay systems.

Due its high sensitivity, the method has the potential to minimize sample preparation, in some cases, even to the point of direct sample injection.

Application of this method is further simplified by using the Analyst software to customize the presentation of results, allowing only relevant information to be displayed for rapid interpretation and use.

Acknowledgements

Applied Biosystems/MDS SCIEX acknowledges Stephen Lock, Daniel Blake and Michael Baynham, and our collaborator Keith Allen from Leeds Teaching Hospitals NHS Trust, UK for providing the method, samples and data for this application note
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