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Setting up a kinase profiler with IMAP

range of IMAP assays to be developed. In those assays where the ATP concentration required is greater than 30 M or substrate sequences contain a number of acidic residues, the IMAP Progressive Binding System provides maximum flexibility, while the IMAP Tween reaction buffer minimizes inhibitor aggregation and sequestration. The IMAP Substrate Finder kits enable researchers to efficiently determine the best substrates to use for profiling and speed assay development. By virtue of the availability of both 5FAMand 5TAMRA-labeled substrates and the relatively high (100 nM) fluor concentration employed, the IMAP system can be designed for maximum resistance to interferences from your specific drug candidates.


ENDNOTES
For more information about these and other IMAP products, go to the Reagents area of the Molecular Devices web site at www. moleculardevices.com.


KINASE INHIBITION REFERENCES
1. F. Meggio, D.A. Donella, M. Ruzzene, A.M. Brunati, L. Cesaro, B. Guerra, T. Meyer, H. Mett, D. Fabbro, P. Furet, et al. Different susceptibility of protein kinases to staurosporine inhibition. Kinetic studies and molecular bases for the resistance of protein kinase CK2. Eur J Biochem 1995 234(1):31722.

2. C.M. Seynaeve, M.G. Kazanietz, P.M. Blumberg, E.A. Sausville, P.J. Worland. Differential inhibition of protein kinase C isozymes by UCN-01, a staurosporine analogue. Mol Pharmacol 1994 45(6):120714.

3. S. Leclerc, M. Garnier, R. Hoessel, D. Marko, J.A. Bibb, G.L. Snyder, P. Greengard, J. Biernat, Y.Z. Wu, E.M. Mandelkow, G. Eisenbrand, L. Meijer. Indirubins
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