Navigation Links
SeeSNP Propietary Analysis Advantages

Kevin McKernan, Jim Yang, Betty Woolf, Rey Sequerra, Kathy Makowski, Tom Tang Agencourt Bioscience Corporation, Beverly, MA 01915, USA


Abstract
Understanding genetic variation and its relationship to drug response and disease susceptibility is becoming an increasingly important consideration in drug design and clinical trials. Since the completion of the Human Genome Project, the majority of human genes can be readily resequenced in diseased or drug-responsive populations. Typical studies involve the resequencing of 20500 amplicons in 50 or more patients, generating thousands of sequence traces that need to be analyzed. To efficiently automate the analysis of such resequencing data, Agencourt has developed novel algorithms that enhance the accuracy of automated procedures and maintain the sensitivity that is required for the diverse samples that are often present in cancer biopsies. In this article, we will discuss the common problems encountered in SNP resequencing and the innovative solutions developed at Agencourt.


Introduction
PolyPhred is currently the most popular software tool utilized for analyzing DNA sequencing reads for SNPs (1,2,3). Other programs such as Mutation Surveyor, NovoSNP (4), and Paracel have certain beneficial features that PolyPhred lacks. However, unlike PolyPhred, they do not have a Linux-compatible analysis program that can automatically interface with a database or sequencing pipeline, allowing the automated assembly of thousands of reads.

Since PolyPhred is the most scalable software tool available, Agencourt opted to design algorithms to enhance a
'"/>

Source:


Page: All 1 2 3 4 5 6

Related biology technology :

1. A Positive Selection Assay for Mutation Analysis in Big Blue Animals
2. Epitope-Tagging Vectors for Functional Analysis in Yeast
3. Map and Link Human Genetic Disorders with SSLP Analysis
4. CastAway Precast Gels for Rapid Automated DNA Sequence Analysis
5. Single-cell RT-PCR Analysis of Paramecium Primaurelia with the Eppendorf cMaster RTplusPCR System
6. Structural Analysis of Glycosylated Peptides in Complex Mixtures with Ion Trap MSn
7. Use of Transcriptor Reverse Transcriptase in Microarray Analysis
8. Increased Sensitivity in Microarray Analysis
9. Gene-Expression Analysis of TP, DPD, and TS Using the LightCycler mRNA Quantification KitsPLUS
10. Agilent 2100 Bioanalyzer Automated Analysis System
11. Analysis of Microarray Data
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: SeeSNP Propietary Analysis Advantages

(Date:1/22/2015)... NJ (PRWEB) January 22, 2015 ... technologies such as the Bioruptor® and complete solutions ... system for chromatin immunoprecipitation, alleviating the need for ... and controls needed for ChIP of histones or ...
(Date:1/22/2015)... ALTO, Calif. , Jan. 22. 2015  Varian Medical Systems ... and software, has been honored for its commitment to sustainability ... sustainable companies. Varian is the highest ranked healthcare equipment company ... announced today during the World Economic Forum at ...
(Date:12/25/2014)... The report “Service Quality Management and Telco Customer Experience ... Global Advancements, Worldwide Forecasts & Analysis (2014-2019)” defines and ... of revenues. , Browse 152 market data tables, ... on “Service Quality Management (SQM) and Telco Customer Experience ...
(Date:12/24/2014)...  Vermillion, Inc. (Nasdaq:   VRML), a bio-analytical solutions ... the Company closed its previously announced private placement ... W. Schuler , Birchview Fund LLC and several ... offering expenses.  The proceeds will be used for ...
Breaking Biology Technology:Diagenode Launches Unique Semi-Automated Solution for Chromatin Immunoprecipitation 2Varian Honored Among World's 100 Most Sustainable Corporations 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 3Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 4Vermillion Announces Closing of Equity Financing 2Vermillion Announces Closing of Equity Financing 3
... Pharmaceuticals, Inc. (Nasdaq: PPHM ) today announced that ... $10 million in proceeds. The initial funding of $5 ... The loan agreement includes an option to acquire a ... of certain conditions . MidCap Financial LLC and ...
... quickly and effectively use this invaluable resource. , ... ... announced the availability of a new tutorial suite on the Comprehensive ... the analysis of prokaryotes, including the complete sequences of all publicly ...
... computing power could be sustained for many years to ... National Physical Laboratory (NPL) that is applying advanced techniques ... density of transistors on an integrated circuit doubles every ... this, but experts believed that when the characteristic transistor ...
Cached Biology Technology:Peregrine Pharmaceuticals Enters Into a Loan Agreement for up to $10 Million 2Peregrine Pharmaceuticals Enters Into a Loan Agreement for up to $10 Million 3Peregrine Pharmaceuticals Enters Into a Loan Agreement for up to $10 Million 4New Online Tutorial for the Comprehensive Microbial Resource (CMR) 2
(Date:1/22/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/wxdglm/global_wearable ... "Global Wearable Technologies Market and Applications, Opportunities, Industry ... Forecast 2014-2020" report to their offering. ... that can be worn on the user,s body ...
(Date:12/22/2014)... , Dec. 22, 2014  NXT-ID, Inc. (NASDAQ: NXTD ... company focused on the growing mobile commerce market, announces it ... Robbins for the 2015 International CES debut of the ... will be at the NXT-ID booth January 6th and ...
(Date:12/19/2014)... 18, 2014 Research and Markets ( http://www.researchandmarkets.com/research/86ncd6/micro_market ) ... North America Perimeter Security Systems Market" report to their ... The North American perimeter security market is estimated to grow ... the U.S. market holds a larger share in this market, ...
Breaking Biology News(10 mins):Global Wearable Technologies Market and Applications, Opportunities, Industry Analysis, Segmentation, Size, Growth, Share, Overview, Trends and Forecast 2014-2020 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 3NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 4Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3
... Scientists at the MUHC have made an important discovery ... hormone estrogen causes growth of breast cancer cells. The ... Recherches Cliniques de Montreal (IRCM) identifies 153 genes that ... be used to halt the growth of breast cancer ...
... one-third and one-half of our planet's land surfaces ... a new study is offering insight into the ... of large-scale deforestation in tropical regions on the ... analyzed multiple years of data using the NASA ...
... first structural details of a family of mysterious objects ... variety of bacteria. The discovery was published Aug. 5 ... look at how microcompartments are built, and what the ... of chemistry and biochemistry, and a member of the ...
Cached Biology News:Scientists discover genetic pathway responsible for breast cancer cell growth 2Tropical Deforestation affects rainfall in the U.S. and around the globe 2Tropical Deforestation affects rainfall in the U.S. and around the globe 3Nighttime Dying Linked To Sleep Apnea From Brain Cell Loss 2Nighttime Dying Linked To Sleep Apnea From Brain Cell Loss 3
Plasmid expressing the LacZ reporter gene....
Human SEAP ORF, provided in a pORF plasmid. pORF is an expression plasmid selectable with Ampicillin....
... PYREX Fernbach-style culture flasks have triple baffles ... bottom to achieve maximal oxygen transfer to ... marking spot., A wide range of optional ... Polypropylene colored caps for ease of ...
... 400g of purified RNA samples., , This ... of aqueous RNA samples that have been ... phenol/chloroform, silica, oligo dT etc or other ... the necessary components for the stabilization of ...
Biology Products: