Navigation Links
RNA Interference and Gene Silencing: History and Overview

n worms, whereas experimental results refuting the model have been obtained from Drosophila embryo lysates (26, 27).

RNAi Initiators
Two C. elegans genes, rde-1 and rde-4 ("rde" stands for "RNAi deficient"), are believed to be involved in the initiation step of RNAi. Mutants of these genes produce animals that are resistant to silencing by injection of dsRNA, but silencing can be effected in these animals by the transmission of siRNA from heterozygous parents that are not silencing deficient. The C. elegans rde-1 gene is a member of a large family of genes and is homologous to the Neurospora qde-2 ("qde" stands for "quelling deficient") and the Arabidopsis AGO1 genes ("AGO" stands for "argonaute"; AGO1 was previously identified to be involved in Arabidopsis development). Although the function of these genes in PTGS is unclear, a mammalian member of the RDE-1 family has been identified as a translation initiation factor. Interestingly, Arabidopsis mutants of AGO1, which are defective for cosuppression, also exhibit defects in leaf development. Thus some processes or enzymes involved in PTGS may also be involved in development (1, 3, 17, 18).

RNAi Effectors
Important genes for the effector step of PTGS include the C. elegans rde-2 and mut-7 genes. These genes were initially identified from heterozygous mutant worms that were unable to transmit RNAi to their homozygous offspring (16). Worms wi
'"/>

Source:


Page: All 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24

Related biology technology :

1. More siRNA Vectors for RNA Interference
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: RNA Interference and Gene Silencing History and Overview

(Date:7/10/2014)... Ouagadougou, Burkina Faso (PRWEB) July 10, 2014 ... Burkina Faso, today have access to an additional ... to increase access to contraception at all levels ... combining a lower-dose formulation of a widely used ... injection system. , Burkina Faso is the first ...
(Date:7/10/2014)... 2014 Deep Knowledge Ventures last ... on ‘Commercialising Longevity Research’ and welcomed a host ... London Bioscience Innovation Center for the event, organised ... Analytics Ltd. The meeting highlighted the need for ... for age-related disease, as well as the crucial ...
(Date:7/10/2014)... Boston, Mass. (PRWEB) July 10, 2014 ... , today announced that Alan Swahn, a former vice ... Terascala’s executive team as vice president of marketing. Terascala’s ... from Dell and NetApp create the highest performance and ... has been appointed to guide Terascala’s channel expansion and ...
(Date:7/10/2014)... July 10, 2014 Robert Harman, DVM, Founder ... company, is proud to announce the relaunch of his highly ... a new series called “ What are Stem Cells ?” ... honest and straightforward foundation in the basics of stem cell ... on the right type of treatment when considering regenerative medicine. ...
Breaking Biology Technology:Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 2Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 3Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 4Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 5Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 6DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 2DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 3DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 4DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 5DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 6Terascala Expands Executive Team 2Terascala Expands Executive Team 3Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 2Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 3
... Thieme's new book, Islands in the Clickstream is ... WTN will be reprinting excerpts from selected chapters of Islands ... week features an excerpt from chapter four, Hacking and the ... of Thieme's writings. , , Hactivism and Soul Power ...
... this summer, we looked at venture capital funding in ... reached about $5 billion in investments in small companies. ... $5.4 billion invested during the fourth quarter of 2003, ... results for the second quarter of 2004 were a ...
... Source: Office of U.S. Rep. Jane Harman (D-Redondo Beach, Calif.) ... Republican? , ,As silly as that question is, it appears ... lamentable wedge issues of the 2004 presidential campaign. Both political ... a back seat to stem cell politics. , ,If you ...
Cached Biology Technology:Islands in the Clickstream: Hactivism and Soul Power 2Islands in the Clickstream: Hactivism and Soul Power 3Islands in the Clickstream: Hactivism and Soul Power 4Midwest life science companies capture 3% of VC investments in Q.2 2Dividing stem cells along partisan lines isnt a good experiment 2Dividing stem cells along partisan lines isnt a good experiment 3
(Date:7/13/2014)... New research raises the prospect of more effective ... muscle occurring in about half of all cancer patients, ... Dana-Farber Cancer Institute. , Many strategies have been tried ... that patients can,t endure potentially life-saving treatments, but none ... July 13 advanced online edition of Nature , ...
(Date:7/11/2014)... 2014--Researchers at the Department of Energy,s Oak Ridge ... presented by R&D Magazine in recognition of the ... recognize the tremendous value of our National Labs," ... development at the National Labs continues to help ... the scientific and technological innovations necessary to remain ...
(Date:7/11/2014)... of Entiat on Tuesday, July 8, 2014. Despite the ... over 1,000 acres by evening. Three outbuildings were damaged. ... the Washington Department of Natural Resources. The fire ... fire control strategies and tactics. Other cooperators include the ... Resources, (WA DNR), Bureau of Land Management, Chelan County ...
Breaking Biology News(10 mins):Antibody halts cancer-related wasting condition 2Antibody halts cancer-related wasting condition 3ORNL wins eight R&D 100s 2ORNL wins eight R&D 100s 3ORNL wins eight R&D 100s 4
... New findings from Van Andel Research Institute (VARI) scientists ... and other stresses in harsh environments to combat global food ... in Nature last year that were named among ... "I think that the work established the methodologies and ...
... women in the US, the association between the consumption of ... diabetes mellitus (late onset diabetes) was studied for 12 years. ... but the regular moderate intake of both caffeinated coffee and ... diabetes significantly. This paper is particularly important ...
... Sebelius at the U.S. Department of Health and Human ... specific challenges to proposed modifications to HIPAA Privacy and ... its membership of 4,000 informatics professionals, detail key issues ... (NPRM) on HIPAA modifications, along with suggestions for models ...
Cached Biology News:New VARI findings next step to growing drought-resistant plants 2AMIA cites concerns about proposed HIPAA modifications 2AMIA cites concerns about proposed HIPAA modifications 3AMIA cites concerns about proposed HIPAA modifications 4
Direct ELISA Assay Diluent - EDTA, 10 L...
... Immunogen: Synthetic peptide derived from ... junctophilin-3. Specificity: Specific for the ... Reactivity: Mouse (positive controls: mouse ... heart tissues). Applications: Western blotting ...
... agarose gel electrophoresis into an automated, high-throughput ... bufferless, pre-cast system is ideal for analyzing ... and more. Fully automated, robot-compatible, and ready ... system makes your high-throughput screening assignments as ...
...
Biology Products: