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RNA Interference and Gene Silencing: History and Overview

. Curr Opin Genetics & Development 12:225-232.

  • Bernstein E, Caudy AA, Hammond SA, and Hannon GJ. (2001) Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature 409:363-366.

  • Nykanen A, Haley B, and Zamore PD. (2001) ATP requirements and small interfering RNA structure in the RNA interference pathway. Cell 107:309-321.

  • Lipardi C, Wei Q, and Paterson BM. (2001) RNAi as random degradative PCR. siRNA primers convert mRNA into dsRNA that are degraded to generate new siRNAs. Cell 107:297-307.

  • Ketting RF, Haverkamp TH, van Luenen HG, and Plasterk RH. (1999). Mut-7 of C. elegans, required for transposon silencing and RNA interference, is a homolog of Werner syndrome helicase and RNase D. Cell 99: 133-141. (Abstract)

  • Grishok A, Pasquinelli AE, Conte D, Li N, Parrish S, Ha I, Baillie DL, Fire A, Ruvkun G, and Mello CC. (2001) Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing. Cell 106:2334.

  • Hutvagner G, McLachlan J, Pasquinelli AE, Balint E, Tuschl T, and Zamore PD. (2001) A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA. Science 293(5531):834-838.

  • Ketting RF, Fischer SE, Bernstein E, Sijen T, Hannon GJ,
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