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RNA Interference and Gene Silencing: History and Overview

A>Dzitoyeva S, Dimitrijevic N, Manev H. (2001) Intra-abdominal injection of double-stranded RNA into anesthetized adult Drosophila triggers RNA interference in the central nervous system. Mol Psychiatry 6(6):665-670.

  • Worby CA, Simonson-Leff N, Dixon JE. (2001) RNA interference of gene expression (RNAi) in cultured Drosophila cells. Sci STKE Aug 14, 2001(95):PL1.

  • Schmid A, Schindelholz B, Zinn K. (2002) Combinatorial RNAi: a method for evaluating the functions of gene families in Drosophila. Trends Neurosci 25(2):71-74.)

  • Hamilton AJ, Baulcombe DC. (1999) A species of small antisense RNA in posttranscriptional gene silencing in plants. Science 286: 950-952. (Abstract)

  • Hammond S, Bernstein E, Beach D, and Hannon G. (2000). An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells. Nature, 404: 293-298. (Abstract)

  • Zamore PD, Tuschl T, Sharp PA, and Bartel DP. (2000). RNAi: Double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. Cell 101: 25-33. (Abstract)

  • Hutvagner G, and Zamore PD. (2002) RNAi: nature abhors a double-strand
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