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Quantitation of the Protein MIA as a Marker for,,,Chondrocytes in Research Samples

atic diseases, the most significant increase in MIA serum concentrations was measured in subjects with rheumatoid arthritis, associated with rheumatoid factor positivity and joint destruction. Therefore, MIA may be useful to discriminate rheumatoid arthritis from nondestructive rheumatic diseases. Further studies are necessary to confirm these preliminary findings.

Our studies indicate that MIA may be a useful marker for cartilage diseases and the monitoring of chondrocytic differentiation in cell culture. We conclude that MIA has the potential to replace other markers due to its improved applicability.


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