Navigation Links
Quantitation of GAD67 Gene Expression in Prefrontal Cortex of Schizophrenia Patients Using the iCycler iQ Detection System and Molecular Beacons, Rev A

schizophrenics and 10 control subjects that were closely matched for PMI were compared (Figure 4).

All schizophrenics in this study had been exposed to neuroleptic drugs for decades. The history of neuroleptic exposure for each subject was assessed in detail by examination of his or her medical charts. Of the 26 schizophrenics, 13 had been exposed to neuroleptics within 1 week of death, while neuroleptic medications had been discontinued for the remaining 13 subjects from 1 week prior to death to as long as 124 weeks prior to death. To assess the possible influence of acute neuroleptic exposure on GAD67 gene expression, the schizophrenic group was subdivided into those who had been exposed to neuroleptics within 6 weeks of death (n = 16) vs. those who had been neuroleptic free for more than 6 weeks (n = 9). Comparison of GAD67 gene expression in the dorsolateral prefrontal cortex of these 2 groups of schizophrenics did not reveal any significant differences between the 2 groups (p > 0.4, data not shown). Matching of subjects for age and PMI and the examination of possible neuroleptic influences suggest that the detected abnormality was independent of obvious artifacts.

These results indicate that mRNA regulation of GAD67 is significantly changed in the dorsolateral prefrontal cortex of elderly chronically ill schizophrenics.


References
Bunney WE and Bunney BG, Evidence for a compromised dorsolateral prefrontal cortical parallel circuit in schizophrenia, Brain Res Rev 31, 138146 (2000)

Condie BG et al., Cleft palate in mice with a targeted mutation in the γ-aminobutyric acid-producing enzyme glutamic acid decarboxylase 67, Proc Natl Acad Sc
'"/>

Source:


Page: All 1 2 3 4 5 6 7 8 9 10

Related biology technology :

1. Quantitation of Cabergoline at Extremely Low Plasma Concentrations with a Triple Quadrupole Mass Spectrometer
2. Bioanalytical Method Intraday Validation for the Quantitation of Paroxetine in Bovine Plasma using the TSQ Quantum Mass Spectrometer
3. Quantitation of the Protein MIA as a Marker for Chondrocytes in Research Samples
4. Comparison of Different Methods of mRNA Quantitation
5. Quantitation of DNA for Automated Sequencing Using the VersaFluor Fluorometer
6. Quantitation of RNA for Hybridization Blots Using the VersaFluor Fluorometer
7. Quantitation of Lymphangiogenesis Using the iCycler iQ Real-Time PCR Detection System and Scorpions Detection System, Rev A
8. Benchmark Plus Microplate Reader: Quantitation of Protein Concentration Using Two Different Colorimetric Assay Kits, Rev A
9. A Robust LC/MS/MS Method for the Quantitation of Very Long Chain Fatty Acids for Research into the Characterization of Peroxisomal Disorders
10. A new LC/MS/MS Research Method for Rapid Quantitation of Five Immunosuppressant Drugs, including Mycophenolic Acid (MPA)
11. Separation and Quantitation of R and S Enantiomers using Normal Phase Chromatography on an API 3000 LC/MS/MS System
Post Your Comments:
(Date:12/24/2014)... , Dec. 24, 2014  United Therapeutics Corporation ... Medtronic, Inc. (NYSE: MDT ) has ... Food and Drug Administration (FDA) for the use ... infusion system (including a newly developed catheter) for ... Injection delivered intravenously to patients with pulmonary arterial ...
(Date:12/24/2014)... and NEW YORK , ... PTBI, PTBIW), a biopharmaceutical company advancing patient care in ... offering of 3,500,000 shares of common stock, and warrants ... common stock, at an offering price of $4.00 per ... per share exercise price of $5.00, are exercisable immediately, ...
(Date:12/24/2014)... 2014  Vermillion, Inc. (Nasdaq:   VRML), a ... today that the Company closed its previously announced ... Jack W. Schuler , Birchview Fund LLC ... million, before offering expenses.  The proceeds will be ... Under the terms of the private ...
(Date:12/24/2014)... 2014   BioLife Solutions , Inc. (NASDAQ: ... of proprietary clinical grade hypothermic storage and ... shipping products for cells and tissues  ("BioLife" or ... 2015 Annual Meeting of Stockholders on May 4, 2015 ... for the Annual Meeting represents a change of more ...
Breaking Biology Technology:United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 3United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 4PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 3Vermillion Announces Closing of Equity Financing 2Vermillion Announces Closing of Equity Financing 3BioLife Solutions Sets Date for Annual Meeting of Stockholders 2
... (NYSE: SGP ) today announced that ... investor relations, effective immediately., In this ... implementing,and continually improving a comprehensive global investor ... formulation and execution of,external and internal investor ...
... September 2008, PLYMOUTH MEETING, Pa., May 27 /Xinhua-PRNewswire-FirstCall/ ... or the ,Company,),today announced that it has received an ... new Propess applicator in China., Prior to today ... induce labor, and is currently distributed via vaginal inserts ...
... Accelerated Community Oncology,Research Network(TM) (ACORN), an ... its expansion of the company,s aggregated ... warehouse. Integrating,patient-reported outcomes (PROs), electronic medical ... systems, garnered from community oncology,practices nationwide ...
Cached Biology Technology:Schering-Plough Appoints Janet M. Barth Vice President, Investor Relations 2BMP Sunstone Receives Import Drug License (IDL) from SFDA 2BMP Sunstone Receives Import Drug License (IDL) from SFDA 3ACORN Expands Oncology Information Portfolio With Comprehensive Data Warehouse 2ACORN Expands Oncology Information Portfolio With Comprehensive Data Warehouse 3
(Date:12/17/2014)... Dec. 15, 2014  HITLAB SM announced ... (GCP) audit to confirm its adherence to current ... accomplishment enables HITLAB to conduct regulated smart device ... principles for patient safety and research quality. ... access, quality, and delivery with innovative technology," said ...
(Date:12/15/2014)... 12, 2014 Research and Markets ... the "Global Facial Recognition Market 2015-2019" ... http://photos.prnewswire.com/prnh/20130307/600769 Facial recognition is ... Facial recognition system measures the overall facial feature ... mouth, and the distance between eyes. Facial recognition ...
(Date:12/11/2014)... 2014  Data Sciences International (DSI), the global ... new series of digital telemetry implants to meet ... series, part of the PhysioTel™ Digital platform, was ... physiologic data when incorporating functional endpoints into repeat-dose ... toxicology studies has evolved from short ECG strips ...
Breaking Biology News(10 mins):HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3New telemetry implants expected to change how large animal toxicology studies are conducted 2
... led by CSIRO Climate Adaptation Flagship and University ... evidence that this ,jellyfish joyride, is associated with ... "Dense jellyfish aggregations can be a ... clear picture is now emerging of more severe ...
... Leiden, The Netherlands, June 09, 2009 / b3c newswire ... B.V. and the Netherlands Organisation for Applied Scientific Research ... collaboration agreement to further develop Amarna’s viral gene ... develop novel methods for the manufacture, formulation and testing ...
... 2009 American Society for Microbiology (ASM) Scherago-Rubin Award ... Virginia,s Department of General Services, Division of Consolidated ... bench-level clinical microbiologist. It was established by the ... ASM,s Clinical Microbiology Division, in honor of her ...
Cached Biology News:'Jellyfish joyride' a threat to the oceans 2Amarna Therapeutics B.V. and TNO announce SVac research and development partnership 2Amarna Therapeutics B.V. and TNO announce SVac research and development partnership 3
Sheep polyclonal to Melatonin ( Abpromise for all tested applications). Antigen: Melatonin Tg conjugate....
Goat anti-PITPN Class: Antibody Product Group: Miscellaneous Antibody...
COMING SOON: Anti-Mouse CD205 (DEC-205),Clone NLDC-145, mAb...
Anti-MT3-MMP Membrane-Type Metalloproteinase-3; propeptide domain; rabbit host...
Biology Products: