Navigation Links
Quantitation of GAD67 Gene Expression in Prefrontal Cortex of Schizophrenia Patients Using the iCycler iQ Detection System and Molecular Beacons, Rev A

schizophrenics and 10 control subjects that were closely matched for PMI were compared (Figure 4).

All schizophrenics in this study had been exposed to neuroleptic drugs for decades. The history of neuroleptic exposure for each subject was assessed in detail by examination of his or her medical charts. Of the 26 schizophrenics, 13 had been exposed to neuroleptics within 1 week of death, while neuroleptic medications had been discontinued for the remaining 13 subjects from 1 week prior to death to as long as 124 weeks prior to death. To assess the possible influence of acute neuroleptic exposure on GAD67 gene expression, the schizophrenic group was subdivided into those who had been exposed to neuroleptics within 6 weeks of death (n = 16) vs. those who had been neuroleptic free for more than 6 weeks (n = 9). Comparison of GAD67 gene expression in the dorsolateral prefrontal cortex of these 2 groups of schizophrenics did not reveal any significant differences between the 2 groups (p > 0.4, data not shown). Matching of subjects for age and PMI and the examination of possible neuroleptic influences suggest that the detected abnormality was independent of obvious artifacts.

These results indicate that mRNA regulation of GAD67 is significantly changed in the dorsolateral prefrontal cortex of elderly chronically ill schizophrenics.


References
Bunney WE and Bunney BG, Evidence for a compromised dorsolateral prefrontal cortical parallel circuit in schizophrenia, Brain Res Rev 31, 138146 (2000)

Condie BG et al., Cleft palate in mice with a targeted mutation in the γ-aminobutyric acid-producing enzyme glutamic acid decarboxylase 67, Proc Natl Acad Sc
'"/>

Source:


Page: All 1 2 3 4 5 6 7 8 9 10

Related biology technology :

1. Quantitation of Cabergoline at Extremely Low Plasma Concentrations with a Triple Quadrupole Mass Spectrometer
2. Bioanalytical Method Intraday Validation for the Quantitation of Paroxetine in Bovine Plasma using the TSQ Quantum Mass Spectrometer
3. Quantitation of the Protein MIA as a Marker for Chondrocytes in Research Samples
4. Comparison of Different Methods of mRNA Quantitation
5. Quantitation of DNA for Automated Sequencing Using the VersaFluor Fluorometer
6. Quantitation of RNA for Hybridization Blots Using the VersaFluor Fluorometer
7. Quantitation of Lymphangiogenesis Using the iCycler iQ Real-Time PCR Detection System and Scorpions Detection System, Rev A
8. Benchmark Plus Microplate Reader: Quantitation of Protein Concentration Using Two Different Colorimetric Assay Kits, Rev A
9. A Robust LC/MS/MS Method for the Quantitation of Very Long Chain Fatty Acids for Research into the Characterization of Peroxisomal Disorders
10. A new LC/MS/MS Research Method for Rapid Quantitation of Five Immunosuppressant Drugs, including Mycophenolic Acid (MPA)
11. Separation and Quantitation of R and S Enantiomers using Normal Phase Chromatography on an API 3000 LC/MS/MS System
Post Your Comments:
(Date:9/15/2014)... developed a technique for controlling the surface tension of ... door to a new generation of reconfigurable electronic circuits, ... fact that the oxide "skin" of the metal ... a surfactant, lowering the surface tension between the metal ... liquid metal alloy of gallium and indium. In base, ...
(Date:9/15/2014)... idea of fibers made of carbon nanotubes is neat, but ... The single-walled carbon nanotubes in new fibers created at Rice ... process designed by chemist Angel Mart and his colleagues. , ... results this month in the journal ACS Nano , ... together into a fiber. , Left to their own devices, ...
(Date:9/15/2014)... (PRWEB) September 15, 2014 Bioptigen ... deep imaging OCT system for the optical device metrology ... EnvisuTM S4410 SDOCT for Contact Lens Metrology ... standard and high complexity contact lens, IOL structures, and ... of a complete contact lens immersed in a hydration ...
(Date:9/15/2014)... Idaho , Sept. 15, 2014  iVinci Health ... only comprehensive Patient Revenue Management system, branded as VisitPay®, ... company also announced the launch of a new extension ... that provides an easy and convenient way for patients ... for balances owed by them and their families. ...
Breaking Biology Technology:Researchers control surface tension to manipulate liquid metals 2Rice rolls 'neat' nanotube fibers 2Rice rolls 'neat' nanotube fibers 3Bioptigen Introduces Deep Imaging OCT System for Contact Lens Metrology 2iVinci Health Raises $5M to Fuel National Expansion, Announces Launch of Personal Finance Portal for Healthcare 2iVinci Health Raises $5M to Fuel National Expansion, Announces Launch of Personal Finance Portal for Healthcare 3
... BEIJING , Feb. 8 /PRNewswire-Asia-FirstCall/ -- China Medical Technologies,Inc. (the "Company") ... participate at the,following investor conferences in March 2010 : , , Investor Conference ... Location, Rodman & Renshaw Annual ... ...
... , Full enrollment occurs five months ahead of ... 8 /PRNewswire-FirstCall/ - Resverlogix Corp. ("Resverlogix" or the "Company") ... Phase 2 clinical study of its lead drug RVX-208. "The ... full 5 months ahead of our original schedule, is a ...
... ... agency, announced today that it has been selected by Invida Group, the leading provider ... communications and public relations program. , ... Salem, MA (Vocus) February 8, 2010 -- LaVoie Group , ...
Cached Biology Technology:China Medical Technologies to Participate Investor Conferences in March 2010 2Resverlogix Completes Patient Recruitment for ASSERT Trial 2Resverlogix Completes Patient Recruitment for ASSERT Trial 3Resverlogix Completes Patient Recruitment for ASSERT Trial 4Invida Selects LaVoie Group as Public Relations Agency of Record 2Invida Selects LaVoie Group as Public Relations Agency of Record 3
(Date:9/15/2014)... is a vital source of energy for both plants ... its way into the cell could lead to the ... increase in the amount of fruits and vegetables farmers ... uncovered one of these "pathways" into the cell by ... a strand of spider silk. , To determine the ...
(Date:9/15/2014)... issue of the journal Science comes out, ... Montana and even the Netherlands, thanks to the type ... norm in these connected times. Yes, the research was ... in biology, medicine, biotechnology and agriculture. It could save ... that one, that one knew another one, and brilliant ...
(Date:9/15/2014)... reef ecologists fears that reef biodiversity may not provide ... once thought. , In an international study published today, ... for Coral Reef Studies (Coral CoE) says we need ... reef ecosystems. , In coral reefs, just as in ... the ecosystem safe and functioning. , Professor Bellwood ...
Breaking Biology News(10 mins):X-rays unlock a protein's SWEET side 2X-rays unlock a protein's SWEET side 3Collaboration drives achievement in protein structure research 2Specialized species critical for reefs 2
... of infection in some hospital wards varies dramatically according ... A University of Leeds-led team studied airflow in a ... two rows of up to 30 bedsby using tracer ... found ventilation in the ward was generally good when ...
... CITY, Calif. , April 16, 2013   DigitalPersona, ... solutions, today announced that Papa John,s restaurants in ... fingerprint biometrics to speed and secure employees, and managers, ... in northern China are using ...
... April 16, 2013 Studies have shown that about ... (HIV) have an elevated resting energy expenditure (REE). Their ... body temperature, and breathing. Most studies have been conducted ... small sample sizes. A team of researchers has sought ...
Cached Biology News:Energy efficiency could increase infection risks in hospital wards 2Energy efficiency could increase infection risks in hospital wards 3Papa John's Restaurants in China Speed and Secure Workflow with DigitalPersona Fingerprint Biometrics 2Women with HIV shown to have elevated resting energy expenditure 2
...
... new Class II safety cabinets Heraeus HERAsafe KS ... user-orientated design. ,The new frameless slanted window ... area. The new front window design makes it ... large work aperture with a height of more ...
... has recently launched a custom synthesis ... (siRNA). Thermos siRNA molecules are: ... 2 DNA bases overhang at the ... Delivered fully deprotected and ready-to-use. ...
Mouse monoclonal [AZ24] to Polo like kinase ( Abpromise for all tested applications)....
Biology Products: