Navigation Links
Quantitation of GAD67 Gene Expression in Prefrontal Cortex of Schizophrenia Patients Using the iCycler iQ Detection System and Molecular Beacons, Rev A

Stella Dracheva, Bronx VA Medical Center, Psychiatry Research,
130 West Kingsbridge Road, Bronx, NY 10468 USA


Introduction
Schizophrenia is a severe mental illness that afflicts about 1% of the population (Strange 1992). Patients experience a variety of symptoms that have been divided into subgroups of positive symptoms (e.g., thought disorder, abnormal beliefs and experiences) and negative symptoms (e.g., deficiency of speech, loss of emotional response, reduced motor function). The etiology and pathophysiology of schizophrenia have been the focus of intensive research for decades. Convergent lines of evidence indicate that dysfunction of a specific area of the cerebral cortex the dorsolateral prefrontal cortex represents one of the central features of the pathophysiology of schizophrenia (Bunney and Bunney 2000). A synthesis of results from in vivo imaging and postmortem studies (Lewis et al. 1999) also suggests that prefrontal cortex dysfunction may be related to abnormalities in the connectivity between neurons in this region that are likely to involve GABAergic interneurons (neurons that synthesize and release the major inhibitory neurotransmitter in the brain, γ-aminobutyric acid or GABA). The synthesis of GABA is catalyzed by the enzyme glutamic acid decarboxylase (GAD). Molecular cloning studies have shown that in the adult brain, GAD exists in 2 isoforms, called GAD65 and GAD67, which are the products of 2 independently regulated genes. GAD65 and GAD67 are coexpressed in GABAergic neurons. Gene lesioning studies in mice (Condie et al. 1997, Kash et al. 1997) suggest that GAD67 is the major isoform and is responsible for the maintenance of basal GABA
'"/>

Source:


Page: All 1 2 3 4 5 6 7 8 9 10

Related biology technology :

1. Quantitation of Cabergoline at Extremely Low Plasma Concentrations with a Triple Quadrupole Mass Spectrometer
2. Bioanalytical Method Intraday Validation for the Quantitation of Paroxetine in Bovine Plasma using the TSQ Quantum Mass Spectrometer
3. Quantitation of the Protein MIA as a Marker for Chondrocytes in Research Samples
4. Comparison of Different Methods of mRNA Quantitation
5. Quantitation of DNA for Automated Sequencing Using the VersaFluor Fluorometer
6. Quantitation of RNA for Hybridization Blots Using the VersaFluor Fluorometer
7. Quantitation of Lymphangiogenesis Using the iCycler iQ Real-Time PCR Detection System and Scorpions Detection System, Rev A
8. Benchmark Plus Microplate Reader: Quantitation of Protein Concentration Using Two Different Colorimetric Assay Kits, Rev A
9. A Robust LC/MS/MS Method for the Quantitation of Very Long Chain Fatty Acids for Research into the Characterization of Peroxisomal Disorders
10. A new LC/MS/MS Research Method for Rapid Quantitation of Five Immunosuppressant Drugs, including Mycophenolic Acid (MPA)
11. Separation and Quantitation of R and S Enantiomers using Normal Phase Chromatography on an API 3000 LC/MS/MS System
Post Your Comments:
(Date:1/22/2015)... Davis, California (PRWEB) January 22, 2015 ... of Accelerator Mass Spectrometry (AMS) services to the pharmaceutical ... PhD has joined the company in the position of ... 30 years of broad and valuable experience in drug ...
(Date:1/22/2015)... January 21, 2015 Cambridge Semantics, the leading ... today announced that 2014 was a record-breaking year across the ... of the Anzo Smart Data Platform and our Smart Data ... insights from diverse data which led to record growth for ...
(Date:1/22/2015)... 2015 zFlo Motion , a US ... an exciting product from a new partner. STT-Systems ... the past 15 years, with offerings in the optical-motion capture, ... IMU system (inertial measurement unit), iSen, is opening eyes around ...
(Date:1/22/2015)... NEW BRUNSWICK , Nueva Jersey , 22 ... Award for Biomedical Research abre hoy su llamada ... las personas cuya investigación científica ha hecho, o tiene ... de la salud humana. Las nominaciones se aceptarán hasta ...
Breaking Biology Technology:Eckert & Ziegler Vitalea Science appoints Mark Seymour, PhD as Director of Science & Technology 2Eckert & Ziegler Vitalea Science appoints Mark Seymour, PhD as Director of Science & Technology 3Cambridge Semantics Announces Record Results for 2014 23D Motion Capture Just Got Easy 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 3El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 4
... - United Arab Emirates   is the First ... to Region,s Allergy Sufferers - Nycomed, a ... now available in the United Arab Emirates for the treatment ... fever, in adults and adolescents over the age of 12. ...
... 13, 2012   Health Care Compliance Strategies, Inc. ... System of Wichita, Kansas has realized a 90% ... months after selecting and implementing COI-SMART, the system ... (Logo: http://photos.prnewswire.com/prnh/20061010/NYTU194LOGO ) ...
... DALLAS, March 13, 2012   Kimberly-Clark Corporation (NYSE: ... "Bob" Stargel Jr., vice president of Global Nonwovens, has ... "Most Influential Blacks in Corporate America." The Top ... international business leaders and executives representing a diverse range ...
Cached Biology Technology:Nycomed, a Takeda Company, Launches Omnaris® Nasal Spray in the UAE for the Treatment of Allergic Rhinitis 2Nycomed, a Takeda Company, Launches Omnaris® Nasal Spray in the UAE for the Treatment of Allergic Rhinitis 3Nycomed, a Takeda Company, Launches Omnaris® Nasal Spray in the UAE for the Treatment of Allergic Rhinitis 4Conflict of Interest Management System Selected by Via Christi Health 2Conflict of Interest Management System Selected by Via Christi Health 3Kimberly-Clark's Bob Stargel Named One of Savoy Magazine's Top 100 Most Influential Blacks in Corporate America 2Kimberly-Clark's Bob Stargel Named One of Savoy Magazine's Top 100 Most Influential Blacks in Corporate America 3
(Date:1/22/2015)... TORONTO , Jan. 13, 2015 /PRNewswire/ - Today, FindBiometrics, the ... announced the launch of its new website design. ... in its infancy", says Peter O,Neill , founder and ... ever, the industry needs involvement from the key players on ...
(Date:1/22/2015)... , Jan. 16, 2015  A man-made form of ... and other mental capabilities in adults with mild cognitive ... study led by researchers at Wake Forest Baptist Medical ... diagnosed with amnesic mild cognitive impairment (MCI) or mild ...
(Date:1/22/2015)... , Europe,s most prestigious innovation ... to present a video retrospective of the most exciting and innovative ... Toumazou and Sophie Wilson   A different ...   Starting on 22 January 2015 on   http://www.epo.org/european-inventor   ...
Breaking Biology News(10 mins):Identity Industry Leading Publication Debuts New Look As Biometrics Hit Mainstream 2Nasal Spray with Insulin Equivalent Shows Promise as Treatment for Adults with Mild Cognitive Impairment, Alzheimer's Dementia 2Nasal Spray with Insulin Equivalent Shows Promise as Treatment for Adults with Mild Cognitive Impairment, Alzheimer's Dementia 3Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 2Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 3
... in Cte d,Ivoire, researchers estimate that this endangered subspecies has ... last survey was conducted 18 years ago. The few remaining ... living in Ta National Park, according to a report in ... Cell Press publication. This alarming decline in a country ...
... When it comes to embryo formation in the ... to enhanced developmental precision, according to a study in ... Cincinnati Children,s Hospital Medical Center. While the fundamentals ... one day they could matter quite a bit to ...
... different parts of the brain can come under attack in ... in mice with an MS-like disease, the brain,s response to ... the spinal cord or cerebellum that comes under fire. The ... in Baltimore and Washington University in St. Louiswill be published ...
Cached Biology News:In a last 'stronghold' for endangered chimpanzees, survey finds drastic decline 2Scientists trace molecular origin of proportional development 2Scientists trace molecular origin of proportional development 3
Mouse monoclonal antibody to FMN2 - formin 2...
...
Anti-Human Complement Component C4c, IgY fraction (Polyclonal) (chicken IgY)...
... (KLF15) KLF15 is a Cys2-His2 zinc ... in the liver, kidneys, heart, and skeletal ... Polyclonal antibody produced in rabbits immunized with ... of human KLF15 with an internal ID ...
Biology Products: