Navigation Links
Quantitation of Cabergoline at Extremely Low Plasma Concentrations with ,,, a Triple Quadrupole Mass Spectrometer

d enrichment of the analyte concentration, and a large injection volume (150 L) representing 75% of the extracted sample.[6] In contrast, using the TSQ Quantum, superior cabergoline sensitivity was achieved with minimally-treated samples and a much smaller injection volume (5 L). Thus, the detection limit for cabergoline on the TSQ Quantum is almost 20 times lower than that attained on the TSQ 7000.[6,8,11] The calibration curve for cabergoline obtained on the TSQ Quantum shows a linear dynamic range covering 5 orders of magnitude (1 x 105) with a correlation coefficient of R > 0.999 using a weighting factor of 1/x (Figure 4). Intra-assay accuracy and precision was evaluated for n >= 5 samples at each calibration level. The accuracy and precision numbers obtained over this extended linear dynamic range are shown in Table 1. The LLOQ (50 fg on column) had an accuracy (%RE) and precision (%CV) of 13.6% and 9.3% respectively. The %RE and %CV for all the other calibration levels (0.5 pg to 5000 pg on column) ranged from -7.5% to 1.6% and 0.5 to 8.4%, respectively. The linear dynamic range for the TSQ Quantum is considerably broader than that achievable on the TSQ 7000 (which was less than 2 orders of magnitude for this assay).[6,7] The significance of this extended linear dynamic range is that a single method can now be developed for cabergoline for application in both low and high dose pharmacokinetic analyses.

It is typical for the response of older generation mass spectrometers to be nonlinear and/or for detector saturation to occur for linear dynamic ranges as low as 3 orders of magnitude. This is particularly problematic for assays where drugs and their metabolites are present in vastly different concentrations and for the ana
'"/>

Source:


Page: All 1 2 3 4 5 6 7 8

Related biology technology :

1. Bioanalytical Method Intraday Validation for the Quantitation of Paroxetine in Bovine Plasma using the TSQ Quantum Mass Spectrometer
2. Quantitation of the Protein MIA as a Marker for Chondrocytes in Research Samples
3. Comparison of Different Methods of mRNA Quantitation
4. Quantitation of DNA for Automated Sequencing Using the VersaFluor Fluorometer
5. Quantitation of RNA for Hybridization Blots Using the VersaFluor Fluorometer
6. Quantitation of Lymphangiogenesis Using the iCycler iQ Real-Time PCR Detection System and Scorpions Detection System, Rev A
7. Quantitation of GAD67 Gene Expression in Prefrontal Cortex of Schizophrenia Patients Using the iCycler iQ Detection System and Molecular Beacons, Rev A
8. Benchmark Plus Microplate Reader: Quantitation of Protein Concentration Using Two Different Colorimetric Assay Kits, Rev A
9. A Robust LC/MS/MS Method for the Quantitation of Very Long Chain Fatty Acids for Research into the Characterization of Peroxisomal Disorders
10. A new LC/MS/MS Research Method for Rapid Quantitation of Five Immunosuppressant Drugs, including Mycophenolic Acid (MPA)
11. Separation and Quantitation of R and S Enantiomers using Normal Phase Chromatography on an API 3000 LC/MS/MS System
Post Your Comments:
(Date:9/17/2014)... Terracon Corporation has announced the introduction of a ... This addition to the company’s industry-leading line of custom ... available in 125 or 250 gallon capacities. It ... or less. , The new pre-engineered TerraPure tank offers ... TerraPure tank line – plus quick turnaround. An ...
(Date:9/17/2014)... , Sept. 17, 2014 /PRNewswire/ - SQI Diagnostics Inc. ... develops and commercializes proprietary technologies and products for advanced ... been approved for trading in the United ... is expected to commence on September 17, 2014 on ... continue to trade on the TSX Venture Exchange under ...
(Date:9/17/2014)... (PRWEB) September 17, 2014 Beckman ... advances science and healthcare, has renewed its agreement with ... As part of the agreement, Personify will continue to ... sustained emphasis on recruitment analytics, including time-to-fill, time-to-source and ... renew our agreement with Personify was based on the ...
(Date:9/17/2014)... The Pistoia Alliance, a global not ... to innovation in life sciences R&D through pre-competitive ... as Executive Director Business Development North America, as ... , Carmen joins the Pistoia Alliance from Accelrys ... Accelrys, she managed various life sciences and material ...
Breaking Biology Technology:Terracon Introduces Pre-Engineered TerraPure® Tank for Ultrapure Water Applications 2SQI Diagnostics to begin Trading on the OTCQX Marketplace in the United States 2SQI Diagnostics to begin Trading on the OTCQX Marketplace in the United States 3Beckman Coulter Signs 3-year RPO Contract with Personify 2Beckman Coulter Signs 3-year RPO Contract with Personify 3Pistoia Alliance Expands Business Development with Appointment of Carmen Nitsche 2
... Up in the sky. It's a bird. It's a plane. It's ... denial in a single bound. Indeed, lately the media has been ... to result from the mass exodus of Baby Boomers from the ... believe that this trend and its impacts on businesses are black ...
... Milwaukee, Wis. - The National Cancer Institute ... Medical College of Wisconsin to study the growth ... second successful renewal of the grant that was first awarded ... ongoing principal investigator. , ,She and other investigators are developing ...
... This is the ninth in a series of articles ... sectors. The most recent article focused on worker classification. ... The idea is developed. Lawyers and accountants are on ... is formed. The name has been chosen. Perhaps workers, ...
Cached Biology Technology:Shades of gray: Business impacts of an aging workforce 2Shades of gray: Business impacts of an aging workforce 3Shades of gray: Business impacts of an aging workforce 4Shades of gray: Business impacts of an aging workforce 5Shades of gray: Business impacts of an aging workforce 6Early Stage, Step 9: Raising capital in the securities landscape 2Early Stage, Step 9: Raising capital in the securities landscape 3Early Stage, Step 9: Raising capital in the securities landscape 4
(Date:9/17/2014)... of Spanish researchers have obtained the first partial genome ... century pig found at the site of the Montsoriu ... ancient pig is closely related to today,s Iberian pig. ... crossed with modern Iberian pigs. , The study, published ... aspects of pig species, and particularly on that of ...
(Date:9/17/2014)... in the human retinoblastoma protein gene are a leading ... have turned to fruit fly eyes to unlock the ... a paper featured on the cover of the current ... Michigan State University researchers provide the first detailed examination ... in the human cancer gene, said Irina Pushel, MSU ...
(Date:9/17/2014)... Washington, DC A team of researchers working on a ... that coral growth rates have plummeted 40% since the ... playing an important role in this perilous slowdown. ... peril facing coral reefs, the team compared current measurements ... Great Barrier Reef with similar measurements taken more than ...
Breaking Biology News(10 mins):Iberian pig genome remains unchanged after 5 centuries 2Abnormal properties of cancer protein revealed in fly eyes 2Coral growth rate plummets in 30-year comparison 2
... and American Board of Internal Medicine (ABIM) announce the ... performance evaluation tools for blood specialists. , ... ABIM certification, ASH and ABIM have co-developed the Hematology ... to complete their practice performance assessment requirement for recertification. ...
... research project which could revolutionise the diagnosis and treatment ... four-year project, the results of which are now being ... means of identifying the two most deadly forms of ... for practitioners. , The implications for improving children's health ...
... to ferns to create a novel energy scavenging device that ... provide a method for powering micro and nano devices with ... works," said Michel Maharbiz, assistant professor of electrical engineering and ... the device. "If you build these things they will move. ...
Cached Biology News:New tool helps blood specialists improve patient care 2Hope for major advance in fighting world killer disease 2Hope for major advance in fighting world killer disease 3Ferns provide model for tiny motors powered by evaporation 2
...
Tissue-Stat ( Tissue Adherent for Mounting Formalin-Fixed and Frozen Tissue Sections.)...
This monoclonal antibody specifically recognizes Y. pestiscapsular F1 antigen. It does not cross-react with Y. pseudotuberculosisor Y. enterocolitica....
Clarin Mounting Medium (Permanent environmentally safe mounting medium for general histology & cytology use)...
Biology Products: