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gative-control siRNAs
  • Efficient gene silencing high-purity, HPLC-purified siRNA
  • State-of-the-art siRNA design to maxmize gene-silencing potential
  • A cost-efficient method to study large numbers of genes economically Cost-effective screening of multiple genes

    The application of RNAi technology to mammalian cells has revolutionized the field of functional genomics. In RNAi, genespecific inhibition is mediated by short
    double-stranded RNA (dsRNA) that has a short sequence homologous to a region of the mRNA transcribed from the target gene. The ability to simply, effectively, and specifically down-regulate the expression of genes in mammalian cells holds enormous scientific, commercial, and therapeutic potential. With the growing acceptance and adoption of siRNA, methodologies are required that offer an economical way to study larger numbers of genes. The Cancer siRNA Oligo Set provides a cost-efficient method by which a large number of cancerrelated genes can be studied.

    Highly efficient silencing of cancer-related genes

    The cancer-related genes in the Cancer siRNA Oligo Set were chosen in collaboration with leading academic cancer researchers (see Table 1 for a list of genes). Each siRNA has been designed using state-of-the-art criteria to give a high success rate in gene silencing. To increase the likelihood of efficiently silencing the expression of the target gene, 2 siRNAs are included for each gene. All siRNAs are synthesized using patented TOM-amidite chemistry to yield high-quality, high-purity, 21-nucleotide sense and antisense RNA oligonucleotides. The single-str
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