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QBT Fatty Acid Uptake Assay Kit datasheet



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FATTY ACID UPTAKE AND TRANSPORTERS

Fatty acids are utilized for diverse cellular processes including mitochondria oxidation, membrane synthesis and energy storage. Pathologically increased intracellular fatty acid concentrations can cause cellular apoptosis and have been linked to insulin desensitization, Type 2 diabetes, obesity and cardiovascular disease. All of these intracellular processes are dependent upon fatty acids traversing the plasma membrane to get into the cell. Therefore, understanding the Fatty Acid Transport Proteins (FATP) that regulate this process is of great importance in biomedical research and drug discovery.

FATPs are part of an evolutionarily conserved family of proteins of which six FATP family members are expressed in the human genome. While all six human FATPs are similar in function, they differ dramatically in their expression in various tissue and organs. The differences in FATP expression pattern therefore make it possible to selectively target the uptake of fatty acids into specific organs by using compounds that can discriminate between the different FATP family members.


CONVENTIONAL METHODS
The development of fatty acid uptake regulators as potential drugs for metabolic diseases requires robust assays for the quantitation of fatty acid uptake. Conventional protocols utilizing radioactivity often require cell lysis and processing at very low temperature, making them expensive, slow and not suitable for high throughput screening. Fluorescence-based protocols generally require the use of low throughput Fluorescence Activated Cell Sorter (FACS) instrumentation, or require cell washing, which can severely com
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