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Proteomics in Bladder Cancer Research: Protein Profiling of Bladder Squamous Cell Carcinomas, Rev C

disease may exhibit expression profiles and immunofluorescent staining patterns that closely resemble those observed in the invasive tumors. These lesions, if detected, may provide important clues about protein expression profiles and immunofluorescence patterns that may be associated with bad prognosis.

To illustrate the approach, Figure 4 shows immunofluorescent staining of cryostat sections of an SCC tumor (Figures 4B, E, H, K, and N) and urothelium with field disease (Figures 4C, F, I, L, and O) obtained from a patient with invasive disease. As depicted in the figure, the tumor does not stain with keratin 19 antibodies (Figure 4B), is BG3C8-antigen positive (Figure 4E) (Celis et al. 1996b), keratin 13 negative (Figure 4H), keratin 14 positive (Figure 4K), and psoriasin negative, with the exception of the pearls (Figure 4N). Similar analysis of the urothelium with field disease revealed a small area (indicated with large arrows) that stained weakly with the keratin 19 antibody (Figure 4C, indicated with an arrow) and that is BG3C8-antigen positive (Figure 4F), keratin 13 negative (Figure 4I), keratin 14 positive (Figure 4L), and psoriasin negative (Figure 4O). Other regions of the urothelium, one of which is indicated with small arrows, showed immunofluorescence patterns that were clearly different from those observed in the invasive tumor. We believe that a thorough analysis of the different antigen expression patterns detected in tumors and urothelium with field disease may prove instrumental in identifying those that may progress to invasive disease. As reference, we show in Figures 4A, D, G, J, and M immunofluorescence pictures of cryostat sections from normal urothelium obtained from another patie
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