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Proteomics in Bladder Cancer Research: Protein Profiling of Bladder Squamous Cell Carcinomas, Rev C

ring Patients
Proteome analysis of fresh SCCs as well as of patients urine using 2-D PAGE and protein identification techniques has so far revealed a single biomarker, the calcium-binding and chemoattractant protein psoriasin (Madsen et al. 1991), which is synthesized by some differentiated cells in SCCs and that can be detected in the urine of SCC patients using immunoblotting in combination with enhanced chemiluminescence detection (Celis et al. 1996b, Rasmussen et al. 1996, stergaard et al. 1997). With the exception of urothelial tissue undergoing keratinizing and nonkeratinizing squamous metaplasia, this protein is not expressed in detectable amounts by any other cell type in the urinary tract (Celis et al. 1996b, stergaard 1997). Psoriasin, alone or preferably in combination with other biomarkers, may prove valuable for the noninvasive follow-up of SCC patients, in particular males, as we have previously shown that the frequent presence of stratified squamous epithelia in the female trigone may lead to false positives (Celis et al. 1996b).


Identification of Premalignant Lesions
A major aim of our studies is to reveal premalignant lesions that may identify individuals at risk. This goal is being pursued systematically by analyzing the proteome expression profiles and immunofluorescent staining patterns of tumors and urothelial tissue from patients that have undergone cystectomy, that is, removal of the bladder due to invasive disease. Since bladder cancer is a field disease (Slaughter et al. 1953), that is, a large part of the bladder urothelium is at risk of developing disease, we surmised that small areas in the urothelium of patients with field
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