Navigation Links
Proteomics in Bladder Cancer Research: Protein Profiling of Bladder Squamous Cell Carcinomas, Rev C

ring Patients
Proteome analysis of fresh SCCs as well as of patients urine using 2-D PAGE and protein identification techniques has so far revealed a single biomarker, the calcium-binding and chemoattractant protein psoriasin (Madsen et al. 1991), which is synthesized by some differentiated cells in SCCs and that can be detected in the urine of SCC patients using immunoblotting in combination with enhanced chemiluminescence detection (Celis et al. 1996b, Rasmussen et al. 1996, stergaard et al. 1997). With the exception of urothelial tissue undergoing keratinizing and nonkeratinizing squamous metaplasia, this protein is not expressed in detectable amounts by any other cell type in the urinary tract (Celis et al. 1996b, stergaard 1997). Psoriasin, alone or preferably in combination with other biomarkers, may prove valuable for the noninvasive follow-up of SCC patients, in particular males, as we have previously shown that the frequent presence of stratified squamous epithelia in the female trigone may lead to false positives (Celis et al. 1996b).


Identification of Premalignant Lesions
A major aim of our studies is to reveal premalignant lesions that may identify individuals at risk. This goal is being pursued systematically by analyzing the proteome expression profiles and immunofluorescent staining patterns of tumors and urothelial tissue from patients that have undergone cystectomy, that is, removal of the bladder due to invasive disease. Since bladder cancer is a field disease (Slaughter et al. 1953), that is, a large part of the bladder urothelium is at risk of developing disease, we surmised that small areas in the urothelium of patients with field
'"/>

Source:


Page: All 1 2 3 4 5 6 7 8 9 10 11

Related biology technology :

1. Tissue Specificity for Mutation Parallels Tissue Specificity for Cancer
2. Cancer siRNA Oligo Set Version 1.0
3. Cancer-Related miRNAs Uncovered by the mirVana miRNA Microarray Platform
4. Detection of Mutant K-ras in a Kindred With Hereditary Pancreatic Cancer by DGGE
5. Detection of p53 Gene in Breast Cancer by Denaturing Gradient Gel Electrophoresis and the DCode System
6. Genome Wide Profiling of Paired Cancerous and Normal Breast Tissues and Rapid Interpretation of Gene Expression Data
7. A New C-Terminal GST Vector for Protein Production in S. pombe
8. New Mammalian Two-Hybrid System Detects Protein-Protein Interactions
9. Antibodies for Studying NMDA Receptor Protein Expression and Synapse-Specific Immunolabeling
10. Simple, Sensitive, and Rapid Detection of FLAG -Tagged Fusion Proteins
11. New Yeast Cloning System for Producing Proteins with Native Amino Acid Sequences
Post Your Comments:
(Date:8/29/2014)... VANCOUVER , Aug. 29, 2014 /PRNewswire/ - ... (OTCQX: ICOTF), today reported financial results for the ... specified otherwise, are expressed in Canadian dollars and ... Second Quarter 2014 Highlights , ... visual acuity (VA) primary endpoint for subjects enrolled ...
(Date:8/29/2014)... California (PRWEB) August 29, 2014 ... of Energy's 2014 Hydrogen Production R&D Award ... -- by splitting water using sunlight. , Shared ... (NREL) and the University of Nevada, Las Vegas ... work developing models of photoelectrochemical solar-hydrogen production and ...
(Date:8/29/2014)... Boston, MA (PRWEB) August 29, 2014 ... ones in the biotech start-up dense realm of Boston-Cambridge, ... alliances and able investors. James Sherley, the Director of ... made increasing the local and national visibility of his ... in September 2013. , In addition to a social ...
(Date:8/28/2014)... SPIE Fellow Glenn Boreman, Professor and ... and Director of the Center for Optoelectronics and Optical ... and co-founder and Chairman of the Board of Plasmonics, ... Vice President of SPIE, the international society for optics ... recent election results at the Annual General Meeting of ...
Breaking Biology Technology:iCo Therapeutics Announces Second Quarter 2014 Financial Results 2iCo Therapeutics Announces Second Quarter 2014 Financial Results 3iCo Therapeutics Announces Second Quarter 2014 Financial Results 4Livermore Team Awarded for Hydrogen Production Research 2The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 2The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 3The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 4Glenn Boreman, UNC Professor and Plasmonics Co-Founder, Elected to SPIE Presidential Chain 2
(Date:8/29/2014)... how the repeated climatic shifts over the last ... genetic diversity, a team of researchers led by ... Carnaval developed a new biodiversity metric called "phylogeographic ... the genetic variation within species is restricted in ... of biology, and 14 other researchers from institutions ...
(Date:8/29/2014)... such as the prolific bloomer Emiliania huxleyi , ... discovered. The finding contradicts the common view that ... on scarce supplies of thiamine in the ocean to ... about the ocean," says CIFAR Senior Fellow Alexandra ... paper with CIFAR fellows John Archibald (Dalhousie ...
(Date:8/28/2014)... Invasives is now available from the Lady Bird Johnson ... for identifying harmful non-native plant, insect and other invasive ... States cause about $137 billion in economic and other ... kill native plants and more. , "By having streamlined ... invasive species occur, we,re more likely to catch these ...
Breaking Biology News(10 mins):CCNY team defines new biodiversity metric 2Not all phytoplankton in the ocean need to take their vitamins 2Not all phytoplankton in the ocean need to take their vitamins 3Mobile app makes ID of harmful plants, insects in Texas a snap 2
... get their first solid food before 4 months of age ... developing Type 1 diabetes, University of Colorado researchers have found. ... and the CU School of Medicine,s Barbara Davis Center for ... mother is still breast-feeding the baby when solid foods, particularly ...
... N.J. -- The New Jersey Commission on Spinal Cord Injury ... grants, which exceed $1.2 million, fund studies of assisted walking ... spinal cord injury (SCI) and the effects of electrical stimulation ... the ability to advance research to find new treatments that ...
... -- Christopher Field, the founding director of Carnegie,s Department ... Germany,s most prestigious prizes, the Max Planck Research Prize ... knowledge of how life on Earth responds to climate ... biosphere and the atmosphere their work also helps us ...
Cached Biology News:Infants' food linked to higher, lower Type 1 diabetes risk 2Kessler Foundation awarded more than $1.2 million in grants by the NJ Commission on Sci Research 2Kessler Foundation awarded more than $1.2 million in grants by the NJ Commission on Sci Research 3Carnegie's Chris Field receives Max Planck Research Prize 2
Anti-LC3 Polyclonal Antibody Research Focus: cell surface antigens Storage: -20C Shipping Temperature: +4C...
...
... biological cells for DNA isolation. ... plates (includes 96 well plate adapters ... across the entire plate length (max ... Can be used for soil, microorganisms, ...
... Chicken polyclonal to LYZL6 ( ... Antigen: Synthetic ... DYKSYSENLC HVDCQD , corresponding to amino ... Entrez Gene ID: ...
Biology Products: