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Proteomics in Bladder Cancer Research: Protein Profiling of Bladder Squamous Cell Carcinomas, Rev C


Identification of Protein Markers that Define the Degree of Differentiation of SCCs
So far, the analysis of fresh tumors labeled overnight with [35S]-methionine has revealed a few protein markers that are highly up-regulated in the more differentiated lesions. These include the calcium-binding protein psoriasin, the psoriasis associated fatty acid binding protein PA-FABP (FABP-5), galectin 7, the component of the Ras-Raf pathway 14-3-3 sigma (also known as stratifin), and keratins 5, 10, and 14 (Celis et al. 1996b, stergaard et al. 1997 and references therein). Other markers useful in assessing the grade of differentiation and origin of the tumors correspond to keratins 13 and 19. In general, SCCs do not express keratins 7, 8, and 18, but many express abundant levels of keratin 19, which does not seem to be expressed by pure SCCs. Figure 3 shows the protein expression profiles of 2 SCC lesions that differ in their degree of differentiation, SCC 589-1 being the more differentiated one (Figure 3A).

It should be stressed that the above-mentioned markers are not expressed by all cells in a given tumor, a fact that emphasizes the need to perform immunohistochemical analysis in combination with 2-D PAGE in order to interpret the data. To decide which antibody should be included in the immunohistochemistry battery is a long process that requires first the analysis of the protein expression patterns of many tumors exhibiting various degrees of differentiation. Once major protein differences are found, the next step consists of identifying the polypeptides by using proteomic technology.


Identification of a Biomarker Externalized to the Urine by SCC-Bea
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