Navigation Links
Proteomics in Bladder Cancer Research: Protein Profiling of Bladder Squamous Cell Carcinomas, Rev C

Figures 1 and 3), and exhibit distinct squamous features such as pearl formation and keratohyalin bodies. Grading of these tumors is subjective and takes into consideration the degree of nuclear polymorphism, nuclear to cytoplasmic ratio, and chromatin clumping, as well as the number of mitotic cells (Friedell et al. 1983).

To achieve a more reliable and objective classification of bladder SCCs that may eventually pave the way for studies of the molecular mechanisms underlying progression, we are exploring the possibility of using proteome expression profiles of these lesions as fingerprints to identify tumor subtypes and to define their grade of atypia (Celis et al. 1996b, stergaard et al. 1997). Proteins are frequently the functional molecules and, therefore, the most likely to reflect qualitative (expression of new proteins, changes in posttranslational modifications) and quantitative (up and down regulation, coregulated proteins) differences associated with various stages of cancer development. Genes may be present; they may be mutated, but they are not necessarily transcribed. Some messengers are transcribed but not translated, and the number of mRNA copies does not necessarily reflect the number of functional protein molecules (Anderson and Seilhamer 1997). Consequently, because of these uncertainties, focusing on the proteins eliminates many of the problems encountered at the nucleic acid level.

In addition to the above-mentioned studies, we are interested in assaying the urine of patients with SCCs for biomarkers that may be of value for identifying individuals at risk (Celis et al. 1996b, Rasmussen et al. 1996, stergaard et al. 1997). The strategy for searching for such markers is based on a syst
'"/>

Source:


Page: All 1 2 3 4 5 6 7 8 9 10 11

Related biology technology :

1. Tissue Specificity for Mutation Parallels Tissue Specificity for Cancer
2. Cancer siRNA Oligo Set Version 1.0
3. Cancer-Related miRNAs Uncovered by the mirVana miRNA Microarray Platform
4. Detection of Mutant K-ras in a Kindred With Hereditary Pancreatic Cancer by DGGE
5. Detection of p53 Gene in Breast Cancer by Denaturing Gradient Gel Electrophoresis and the DCode System
6. Genome Wide Profiling of Paired Cancerous and Normal Breast Tissues and Rapid Interpretation of Gene Expression Data
7. A New C-Terminal GST Vector for Protein Production in S. pombe
8. New Mammalian Two-Hybrid System Detects Protein-Protein Interactions
9. Antibodies for Studying NMDA Receptor Protein Expression and Synapse-Specific Immunolabeling
10. Simple, Sensitive, and Rapid Detection of FLAG -Tagged Fusion Proteins
11. New Yeast Cloning System for Producing Proteins with Native Amino Acid Sequences
Post Your Comments:
(Date:7/12/2014)... (PRWEB) July 12, 2014 ... various reagents used in the life science ... the life science reagents market towards remarkable ... manufacturers and providers of life science reagents. ... Report: http://www.transparencymarketresearch.com/life-sciences-reagents-analytical-reagents.html . , The global ...
(Date:7/11/2014)... BEACH, Fla. , July 11, 2014 /PRNewswire-iReach/ -- ... of high-quality peptides that are used solely in scientific ... honor two successful years in business, Maxim Peptide, which ... has just launched a new and updated website that ... research blog section has been updated with fascinating articles ...
(Date:7/11/2014)... , July 11, 2014 , ... part) in, into or from any jurisdiction where to do ... such jurisdiction.  Shire plc ("Shire" or the "Company") ... article this afternoon.  Shire confirms it has held a meeting ... made by Shire without the prior agreement or approval of ...
(Date:7/11/2014)... 2014 Research and Markets  has announced ... - Global Industry Analysis, Size, Share, Growth, Trends and ... http://photos.prnewswire.com/prnh/20130307/600769 Transfection ... DNA or RNA) into cells. This technology helps the ... and protein metabolism by affecting the nuclear genes. The ...
Breaking Biology Technology:Transparency Market Research: Life Science Reagents Market- PCR Reagent Kits, Cell and Tissue Culture, Flow Cytometry, Electrophoresis and Chromatography 2Transparency Market Research: Life Science Reagents Market- PCR Reagent Kits, Cell and Tissue Culture, Flow Cytometry, Electrophoresis and Chromatography 3Maxim Peptide Celebrates Second Anniversary Online with an Updated Website and Special Deals Section 2Shire plc - Statement re: Media Speculation 2International Transfection Technology Market - Industry Analysis, Size, Share, Growth, Trends and Forecast to 2019 2
... labeling and mass spectrometry-based techniques, Mark Chance, PhD, director ... Center for Proteomics and Bioinformatics and professor of physiology ... Center for Proteomics and Bioinformatics; and a research team ... were able to take a high resolution picture of ...
... , , ... Ormsby reports: , , , ... that the Company has engaged the services of Robert B. Nealon, Esq. as ... in Nealon & Associates, P.C., a Washington, D.C. based law and government relations ...
... association studies have uncovered a number of DNA variants ... risk variants lie outside of genes, posing a challenge ... In a report published online today in ... a functional DNA element associated with prostate cancer, lending ...
Cached Biology Technology:Case Western Reserve University-led team takes high resolution photo of a K+ channel 2Case Western Reserve University-led team takes high resolution photo of a K+ channel 3IGEN Networks engages new Director and Chairman of the Board 2IGEN Networks engages new Director and Chairman of the Board 3Prostate cancer risk variant found to be in a functional DNA sequence linked with disease 2Prostate cancer risk variant found to be in a functional DNA sequence linked with disease 3
(Date:7/11/2014)... A new report from the Wildlife Conservation Society ... only help economically valuable species such as lobster, ... also help re-colonize nearby reef areas. , The ... a systematic review of research literature from no-take ... by Dr. Craig Dahlgren, a recognized expert in ...
(Date:7/11/2014)... Tenn., July 11, 2014--Researchers at the Department of ... R&D 100 awards, presented by R&D Magazine in ... , "These awards recognize the tremendous value of ... Moniz. "Research and development at the National Labs ... challenges and pursue the scientific and technological innovations ...
(Date:7/11/2014)... were many fires burning in eastern New South Wales, ... 11. , At 03:35 UTC on July 11 (12:35 ... Aqua passed over eastern New South Wales (NSW), the ... visible image of the region and spotted smoke (light ... MODIS,s thermal bands, are outlined in red. , The ...
Breaking Biology News(10 mins):Belize's lobster, conch, and fish populations rebuild in no-take zones 2ORNL wins eight R&D 100s 2ORNL wins eight R&D 100s 3ORNL wins eight R&D 100s 4
... for the popular television show "Are You Smarter than a 5th ... The conventional wisdom: rods and cones. The human retina contains ... movement, and about 7 million cones, which in addition detect color. ... not exist. But that might not be true, according to ...
... of all acute leukemias represents a small population of ... standard treatments available today. Though current chemotherapy can produce ... of experiencing a recurrence and dying from the disease. ... rare form of leukemia called acute promyelocytic leukemia (APL), ...
... ANN ARBOR, Mich.---In cells, as in cities, disposing ... is an essential service. In both city and cell, ... New research by University of Michigan cell ... how the cell,s garbage dump and recycling center, the ...
Cached Biology News:Blind mice can 'see' thanks to special retinal cells 2Grant to fund research into eradicating the leukemia stem cell 2Opening the gate to the cell's recycling center 2
... membrane and filter paper sandwiches are composed ... two sheets of thick filter paper that ... filter paper sandwich. These 7 x 8.5 ... immunoblotting fit Ready Gel-sized gels and are ...
... inhibits protein synthesis. Acts by inhibiting ... Reported to induce apoptosis in a ... cells, Jurkat cells, ventricular myocytes, and ... and immediate early gene induction. Selective ...
... The RC DC protein assay kit I provides ... concentration in the presence of reducing agents and ... colorimetric assay. The kit includes reagents and standards ... reagent I, 250 ml RC reagent II, 250 ...
Recommended for use as a cell culture substratum at 0.1-0.2 mg/cm 2 or 5-10 μl/cm 2 . Optimal concentration depends on cell type as well as the application or research objectives. Type B...
Biology Products: