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Practical Applications of HyperDSC in a Pharmaceutical Laboratory

Author

Svenja Goth
PerkinElmer Life and Analytical Sciences
710 Bridgeport Avenue
Shelton, CT 06484-4794 USA

Didier Clnet Sanofi-Aventis
Analytical Sciences Department
Physical Characterization Laboratory
13, quai Jules Guesde
94403 Vitry-sur-Seine - FRANCE

Topics

Polymorphism
Separation of transitions
Detection of weak transitions

HyperDSC (or High Speed DSC), a thermal technique that complements conventional calorimetry, has over the last few years found applications in the fields of pharmaceutical, polymers and compounds.

This technique features measurements taken at high heating (or cooling) rates, from 100 to 500 C/min. It is an approach that makes it easier to detect such events as glass transition or the melting of a compound when they are concealed by kinetic phenomena like, for example, water vaporization, crystallization or chemical degradation.

Furthermore, HyperDSC offers greatly enhanced analysis sensitivity due to the concentration of the energy phenomena measured into a very brief space of time. Calorimetric analyses on samples of very low mass (below 10 μg) are thus made possible. The detection limits permitted by this technique can be lowered considerably as compared with conventional DSC, down to values < 1% when quantifying physical forms (amorphous or crystalline). HyperDSC analyses can be carried out on the power compensation Diamond DSC from PerkinElmer shown in Figure 1.

Presentation and relevance of Hyper-DSC

First, a quick review of the differences between power compensation DSC and heat-flux DSC is presented. Its design and working principle
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