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Optimizing Your Benchscale Fermentation Process

ollers, and supplemental pumps. An optional eight-port serial connection enables connecting scales or other external devices with serial connections. USB ports enable exporting process data to a PC, as well as importing future firmware and software upgrades.

The sample screens included here provide a glimpse into the advanced processing capabilities of the BioFlo 310.

The main screen is your command central a single location to conveniently see setpoints and current values for all 32 process loops, as well as view as many as 10 loops simultaneously without having to scroll up or down. The screen displays each loop name, process value (PV), setpoint, output percent, control mode, unit of measurement, and whether the loop is in cascade mode. In this example, in addition to standard loops for agitation, temperature, pH, and DO, the bioreactor was built with five optional thermal mass flow controllers (TMFC). Using multiple TMFCs gives users the ability to precisely view and regulate the exact amount of each gas being added to the reactor in standard liters per minute (SLPM). Therefore, loops shown for AirFlo, O2Flo, N2Flo, and CO2Flo are for the four sparge gasses. The fifth TMFC is used for gas overlay, shown in OvlFlo loop, and OvlMix loop indicates gas mixing for the gas overlay.


Creating a loop to integrate control of your external device to the BioFlo 310 is exceptionally easy. Select the loop type depending on the external device, and select whether it is an input and/or output signal. You have the flexibility to create the loop name and unit of measurement, as well as set PID values along with low and high limits. A REMOVE button allows you to easily remove the loop as your requirements change.

Trend graphs can be
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