Navigation Links
Near Infrared Technology and Optical Agents For Molecular Imaging

low 700 nm, tissue absorption results in small penetration depths of only a few millimeters1. Thus in the visible region of the spectrum, only superficial assessment of tissue features is possible.

The light absorption is due to oxy- and deoxyhemoglobin, melanin, lipid, and other compounds found in living tissue2, 3, 4. These compounds cause tissue a u t o f l u o rescence throughout the visible spectral range up to approximately 700 nm5, 6. Because the absorption coefficient of tissue is considerably smaller in the near infrared region (700 nm-900 nm), light can penetrate more deeply into the tissues to depths of several centimeters3, 7, 8.

A key to enabling optical imaging has been the development of suitable NIR fluorochromes with high molar extinction coefficients, good quantum yields and low non-specific tissue binding. There are several commercially available candidate fluorochromes which can be used for optical imaging, including I R D ye 800CW, IRDye 680, IRDye 700DX, Cy5.5, and Alexa Fluor 750. Quantum dots have been used; however, their size often precludes efficient clearance from the circulatory and renal systems and there are questions about their long-term toxicity4.

A number of studies have been published using NIR dyes. Two of the dyes commonly used for optical imaging are Cy5.5 and IRDye 800CW. Cy5.5 has been used in the past primarily due to the lack of other candidate dyes suitable for imaging. Cy5.5 has excitation/emission maxima at 675 nm/694 nm, making it a borderline candidate labeling agent1, 3. In contrast, a recently developed fluoro c h rome, IRDye 800CW, has its excitation/emission maxima at 785 nm/810 nm precisely centered in the region known to give optimal signal to background in optical imaging (see Figure 1)
'"/>

Source:


Page: All 1 2 3 4 5 6 7

Related biology technology :

1. Innovative Tissue Array Technology for High-Throughput Screening of Gene Expression
2. Enhancing Ruggedness and Full-Scan MS Sensitivity Using Ion Sweep Technology
3. Novel MicroRNA Array Technology for Sensitive miRNA Profiling
4. Use of FlashPlate Technology for In Vitro Measurement of [35S]-GTPγS Binding in CHO Cells Expressing the Human 5-HT1B Receptor
5. Use of Novel FlashPlate Technology to Measure cAMP Accumulation in Chinese Hamster Ovary Cells Expressing Human -2 Adrenoreceptors
6. Use of FlashPlate Technology for In Vitro Measurement of 125I-Labeled TGF-1 Binding on Chimeric Extracellular Domain of Type II Transforming Growth Factor Receptor
7. DNA purification from pig ears to bird blood using proven DNeasy Technology
8. Eagle Eye Optical Filter Optimized for Imaging Silver-Stained Gels
9. Detect Single Nucleotide Sequence Changes with Mx4000 Molecular Beacon Allelic Discrimination Kits
10. Genotyping Single Nucleotide Polymorphisms with Molecular Beacons
11. New Protocols for Isolating High- Molecular-Weight Genomic DNA
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Near Infrared Technology and Optical Agents For Molecular Imaging

(Date:7/12/2014)... Albany, New York (PRWEB) July 12, 2014 ... market analysis for various reagents used in ... biotechnology is driving the life science reagents ... this study include manufacturers and providers of ... Science Reagents Market Report: http://www.transparencymarketresearch.com/life-sciences-reagents-analytical-reagents.html . ...
(Date:7/11/2014)... July 11, 2014 /PRNewswire-iReach/ -- Maxim Peptide, a website ... are used solely in scientific experiments, is currently celebrating ... in business, Maxim Peptide, which was created by the ... new and updated website that now features a special ... been updated with fascinating articles about peptide research, including ...
(Date:7/11/2014)... , July 11, 2014 , ... part) in, into or from any jurisdiction where to do ... such jurisdiction.  Shire plc ("Shire" or the "Company") ... article this afternoon.  Shire confirms it has held a meeting ... made by Shire without the prior agreement or approval of ...
(Date:7/11/2014)... Research and Markets  has announced the ... Global Industry Analysis, Size, Share, Growth, Trends and Forecast ... http://photos.prnewswire.com/prnh/20130307/600769 Transfection is ... or RNA) into cells. This technology helps the cells ... protein metabolism by affecting the nuclear genes. The transfection ...
Breaking Biology Technology:Transparency Market Research: Life Science Reagents Market- PCR Reagent Kits, Cell and Tissue Culture, Flow Cytometry, Electrophoresis and Chromatography 2Transparency Market Research: Life Science Reagents Market- PCR Reagent Kits, Cell and Tissue Culture, Flow Cytometry, Electrophoresis and Chromatography 3Maxim Peptide Celebrates Second Anniversary Online with an Updated Website and Special Deals Section 2Shire plc - Statement re: Media Speculation 2International Transfection Technology Market - Industry Analysis, Size, Share, Growth, Trends and Forecast to 2019 2
... - Neuro-Biotech Corporation (PINKSHEETS: MRES) (OTCQB: MRES) ... in the unique international niche of clinical ... opportunity to market 12 clinical "Neuro Blood ... are without equal in being rapidly done ...
... Inc. (Nasdaq: KERX ) today announced that Ron ... the 2010 UBS Global Life Sciences Conference, being held at ... presentation is scheduled to take place on Wednesday, September 22, ... of Mr. Bentsur,s presentation will be accessible from the Investor ...
... Epitomics, Inc. today announced that The Michael J. ... company to distribute a panel of LRRK2 monoclonal antibodies ... parties. Under a special arrangement the antibodies are being ... community to help advance LRRK2 therapeutic development efforts. The ...
Cached Biology Technology:Neuro-Biotech's Solution for a Doctor near You: Early Detection for Alzheimer's and Chronic Fatigue Syndrome! 2Keryx Biopharmaceuticals to Present at the UBS 2010 Global Life Sciences Conference 2Epitomics, Inc. Announces Worldwide Availability of LRRK2 Antibodies Developed in Partnership With The Michael J. Fox Foundation 2
(Date:7/11/2014)... report from the Wildlife Conservation Society shows that ... economically valuable species such as lobster, conch, and ... re-colonize nearby reef areas. , The reporttitled "Review ... review of research literature from no-take areas around ... Craig Dahlgren, a recognized expert in marine protected ...
(Date:7/11/2014)... 2014--Researchers at the Department of Energy,s Oak Ridge ... presented by R&D Magazine in recognition of the ... recognize the tremendous value of our National Labs," ... development at the National Labs continues to help ... the scientific and technological innovations necessary to remain ...
(Date:7/11/2014)... There were many fires burning in eastern New South ... July 11. , At 03:35 UTC on July 11 ... when Aqua passed over eastern New South Wales (NSW), ... natural-color visible image of the region and spotted smoke ... by MODIS,s thermal bands, are outlined in red. , ...
Breaking Biology News(10 mins):Belize's lobster, conch, and fish populations rebuild in no-take zones 2ORNL wins eight R&D 100s 2ORNL wins eight R&D 100s 3ORNL wins eight R&D 100s 4
... large urban areas are at a significantly higher risk ... giving birth compared to those living in rural areas, ... College Hospital,s Dr. Simone Vigod. The study, ... , strongly links geographic location and postpartum depression. The ...
... and colleagues from Chengde Medical College have shown ... heme oxygenase-1 expression in the hippocampus and cerebral ... in diabetic rats, thus protecting the nervous system. ... growth factor 1 axis undergoes abnormal changes in ...
... Energy Department,s National Renewable Energy Laboratory (NREL) has published ... power plants based on actual land-use practices from existing ... of the solar plants in the United States will ... author Sean Ong said. The report, "Land-use Requirements for ...
Cached Biology News:Women in urban areas show high rates of postpartum depression, study finds 2NREL report firms up land-use requirements of solar 2
CELLine System cultivation flask (for secreted products)...
... StabilCoat Plus Microsphere/Microarray Stabilizer is an aqueous ... and other non-toxic chemicals in a PBS ... 7.4. This product contains a combination ... a preservative. StabilCoat Plus Stabilizer provides ...
... The mini incubation trays are ... to screen antigens that have ... Each tray has eight 10.5 ... that accommodate strips cut from ...
... designed for quick and easy protein purification ... two 0.25mm holes laser cut at the ... remain liquid-tight during incubation of the gel ... protein diffuses from the gel into the ...
Biology Products: