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MicroRNA Profiling by Array Analysis Reveals Critical BioMarkers

s and appear to be deleted in the majority of CLL cases [1].

(2) Twenty-eight different miRNAs were identified in human colorectal mucosa; two of these proved to be significantly down-regulated in twelve adenocarcinoma samples compared to matched, normal tissues [2]. The two miRNAs were also down-regulated in the precancerous adenomatous polyps that were tested.

(3) Sequence analysis of tumor cells from eleven Burkitt lymphoma patients revealed that every one had a chromosome rearrangement in the miR-155 gene [3]. None of the twenty-one normal (negative control) individuals tested had the rearrangement.

(4) A comparison of the chromosomal locations of 186 miRNA genes and cancer-associated genomic regions revealed that more than half of the miRNAs (98 out of 186) are in common break-point regions, fragile sites, minimal regions of loss of heterozygosity, and minimal regions of amplification [4].

Each of these reports suggest that miRNAs play a role in oncogenesis. We have developed and used an array procedure to measure miRNA expression in a variety of cancerous samples. The miRNA profiles from these samples suggest that a handful of miRNAs are routinely up- and down-regulated in tumors. The miRNA array procedure is now available and can be used not only for cancer research, but also for the analysis of development, tissue differentiation, and viral regulation.


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