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MicroRNA Profiling by Array Analysis Reveals Critical BioMarkers

s, and many genes appear to be regulated by multiple miRNAs [15]. This could explain why at least some miRNAs have such broad functionality and might also point to complex translational control of some genes.

(2) It has been predicted that the expression of as many as 10% of mammalian genes are regulated by miRNAs [17].

(3) If miRNAs indeed regulate the translation of, but not the stability of, mRNAs, this might at least partially explain why gene expression profiles based on mRNA analysis do not always correlate with protein expression data [18]. As more is learned about the mRNA targets of the different miRNAs, it will be possible to more accurately assess gene expression for a given sample by combining the profiles of mRNA and miRNA expression.


Role of miRNAs as Disease Markers

Given the role of miRNAs in regulating development and differentiation, multiple researchers have investigated the relationship between miRNA and oncogenesis. Several publications report a correlation between aberrant miRNA expression and miRNA gene sites with cancer, including the following:

(1) Chronic lymphocytic leukemia (CLL) patients commonly exhibit a chromosomal abnormality at 13q14. No known tumor suppressor genes exist at this locus and no consistent involvement of any of the genes in the deleted region has been demonstrated. Interestingly, the genes for miR-15 and miR-16 are located at this locu
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