Navigation Links
MicroRNA Profiling by Array Analysis Reveals Critical BioMarkers

s, and many genes appear to be regulated by multiple miRNAs [15]. This could explain why at least some miRNAs have such broad functionality and might also point to complex translational control of some genes.

(2) It has been predicted that the expression of as many as 10% of mammalian genes are regulated by miRNAs [17].

(3) If miRNAs indeed regulate the translation of, but not the stability of, mRNAs, this might at least partially explain why gene expression profiles based on mRNA analysis do not always correlate with protein expression data [18]. As more is learned about the mRNA targets of the different miRNAs, it will be possible to more accurately assess gene expression for a given sample by combining the profiles of mRNA and miRNA expression.


Role of miRNAs as Disease Markers

Given the role of miRNAs in regulating development and differentiation, multiple researchers have investigated the relationship between miRNA and oncogenesis. Several publications report a correlation between aberrant miRNA expression and miRNA gene sites with cancer, including the following:

(1) Chronic lymphocytic leukemia (CLL) patients commonly exhibit a chromosomal abnormality at 13q14. No known tumor suppressor genes exist at this locus and no consistent involvement of any of the genes in the deleted region has been demonstrated. Interestingly, the genes for miR-15 and miR-16 are located at this locu
'"/>

Source:


Page: All 1 2 3 4 5 6 7 8 9 10 11 12 13

Related biology technology :

1. Novel MicroRNA Array Technology for Sensitive miRNA Profiling
2. Getting Started with MicroRNA Research
3. Stratagenes Human cDNA Microarrays: Perform Gene Expression Profiling and Discover New Genes
4. The Flexible matriXarray Chip System: A New Perspective for Probe Optimization in Gene-Expression Profiling
5. Ambion Offers Gene Expression Profiling Service
6. Total RNA from Whole Blood for Expression Profiling
7. Unmask Blood RNA for Gene Expression Profiling
8. Proteomics in Bladder Cancer Research: Protein Profiling of Bladder Squamous Cell Carcinomas, Rev C
9. Microgenomic Expression Profiling
10. Laser Capture Microdissection (LCM) and Expression Profiling of Long-Range Projection Neurons
11. A Novel Process for Gene Expression Profiling of Rat and Mouse Tissues from Formalin-Fixed Paraffin-Embedded Sections Using Microarrays
Post Your Comments:
(Date:10/22/2014)... and BOSTON , Oct. 22, ... a leading global specialty pharmaceutical company, and Rhythm, a ... an exclusive option to acquire Rhythm,s wholly owned subsidiary, ... peptide ghrelin agonist, for the treatment of diabetic gastroparesis ... has completed a successful Phase 2 trial of relamorelin ...
(Date:10/22/2014)... Shimadzu Scientific Instruments introduces its Open ... the pain management and clinical markets. The software increases ... by allowing users to highlight and review results that ... allows analysts to filter results by group or based ... eliminating the need to sift through analytes of no ...
(Date:10/22/2014)... Diego, CA (PRWEB) October 22, 2014 ... balances from Sartorius, A & D Weighing, Rice ... Sartorius CPA Semi-Micro Balance . The Sartorius CPA ... for an affordable high-quality, precise, and user-friendly laboratory ... manufacturing of laboratory equipment, their laboratory balances are ...
(Date:10/22/2014)... According to new market research report ... Integration, Deployment & Support), by Service Model (SaaS, ... Others (Hybrid & Community)) - Global Forecast to ... Cloud Professional Services Market into various sub-segments with ... also identifies the drivers and restraints for this ...
Breaking Biology Technology:Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 2Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 3Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 4Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 5Shimadzu Releases QuantAnalytics Open Access LCMS Software Package for Clinical Applications 2Pipette.com Launches the Addition of Sartorius CPA Semi-Micro Balance to Their Product Portfolio with Special Promotional Pricing 2Pipette.com Launches the Addition of Sartorius CPA Semi-Micro Balance to Their Product Portfolio with Special Promotional Pricing 3Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 2Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 3Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 4Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 5
... , ORANGE COUNTY, Calif., July 27 ... Board of Directors declared a quarterly dividend payout of seventeen cents ($0.17) ... all stockholders of record on August 10, 2009. This payout represents ... (Logo: http://www.newscom.com/cgi-bin/prnh/20031202/BECLOGO ) , , Beckman Coulter, Inc., ...
... , , , ... Calif. and LONDON, July 27 Amgen (Nasdaq: AMGN ... companies will share commercialization of Amgen,s monoclonal antibody denosumab for postmenopausal ... product is approved in these countries. Amgen will commercialize the ...
... , , , ... ZMH ; SWX: ZMH) today announced the launch of ... with teaching surgeons and subject matter experts to develop a unique ... Training and Surgeon-to-Surgeon programs under one, consolidated service offering, the enhanced ...
Cached Biology Technology:Amgen to Collaborate With GlaxoSmithKline to Commercialize Denosumab in Europe for Postmenopausal Osteoporosis (PMO) 2Amgen to Collaborate With GlaxoSmithKline to Commercialize Denosumab in Europe for Postmenopausal Osteoporosis (PMO) 3Amgen to Collaborate With GlaxoSmithKline to Commercialize Denosumab in Europe for Postmenopausal Osteoporosis (PMO) 4Amgen to Collaborate With GlaxoSmithKline to Commercialize Denosumab in Europe for Postmenopausal Osteoporosis (PMO) 5Amgen to Collaborate With GlaxoSmithKline to Commercialize Denosumab in Europe for Postmenopausal Osteoporosis (PMO) 6Amgen to Collaborate With GlaxoSmithKline to Commercialize Denosumab in Europe for Postmenopausal Osteoporosis (PMO) 7Zimmer Launches New Medical Education and BioSkills Training Program 2Zimmer Launches New Medical Education and BioSkills Training Program 3Zimmer Launches New Medical Education and BioSkills Training Program 4
(Date:10/16/2014)... -- NXT-ID, Inc. (NASDAQ: NXTD and ... focused on the growing mobile commerce market announces that ... Smart Wallet, at the 13 th annual Future ... conference on the intersection of technology and the economy. ... founder and publisher of the Strategic News Service™, the ...
(Date:10/15/2014)... our ability to assess the pandemic risk from strains ... we must not allow ourselves to become complacent that ... international consortium of scientists. , Influenza pandemics arise when ... yet to develop widespread immunity – spreads in the ... the past 100 years, the worst of which – ...
(Date:10/15/2014)... Gauß-Allianz has admitted Johannes Gutenberg University Mainz (JGU) ... science hub continues to maintain a significant nationwide ... , "The acceptance of Johannes Gutenberg University Mainz ... a milestone in the national and international competition ... state of Rhineland-Palatinate can be proud that Mainz ...
Breaking Biology News(10 mins):NXT-ID Inc. to Present at 13th Annual FiRe Conference 2NXT-ID Inc. to Present at 13th Annual FiRe Conference 3Scientists 'must not become complacent' when assessing pandemic threat from flu viruses 2Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 2Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 3
... in Nature , researchers at Brandeis University and the ... time shed light on a crucial step in the complex ... in the human cell and frequently at which point genetic ... they were able to crystallize a very large complex of ...
... does inflammation, brought on by stress, affect aging? What can ... crisis of an epidemic of neurologic diseases caused by a ... keep a rosy outlook in the face of inevitable decline? ... host of other questions are the focus of the inaugural ...
... Hughes Medical Research Institute today announced that two researchers ... scientists nationwide to be appointed HHMI Early Career Scientists. ... of the Center,s Basic Sciences Division, and Toshiyasu Taniguchi, ... Biology and Public Health Sciences divisions, each will receive ...
Cached Biology News:A splice of life 2Living long, living well 2Two Hutchinson Center researchers named HHMI Early Career Scientists 2
... for RNA aptamer screening and binding optimization ... Paraflo microfluidic on-chip synthesis platform. These microarrays ... DNA/RNA Aptamer Microarray Service. Probe ... Microarray contains greater than 1500 known aptamer ...
... Sciences provides a comprehensive epitope analysis ... synthesized on Paraflo microfluidic chips for ... development. This comprehensive service includes assistance ... using sample(s) provided by you, single ...
... an extension of Parkers MX80 family of positioners, ... LX80L bolt hole patterns mimic the MX80 family, ... all accessory brackets to build multi-axis systems., , ... 750 mm , Accelerations to 5 gs , ...
... the next step in the evolution of ... system that delivers labware to multiple laboratory ... times the throughput of ordinary microplate robots. ... variety of configurations to meet any labs ...
Biology Products: