Navigation Links
MicroRNA Profiling by Array Analysis Reveals Critical BioMarkers

s, and many genes appear to be regulated by multiple miRNAs [15]. This could explain why at least some miRNAs have such broad functionality and might also point to complex translational control of some genes.

(2) It has been predicted that the expression of as many as 10% of mammalian genes are regulated by miRNAs [17].

(3) If miRNAs indeed regulate the translation of, but not the stability of, mRNAs, this might at least partially explain why gene expression profiles based on mRNA analysis do not always correlate with protein expression data [18]. As more is learned about the mRNA targets of the different miRNAs, it will be possible to more accurately assess gene expression for a given sample by combining the profiles of mRNA and miRNA expression.


Role of miRNAs as Disease Markers

Given the role of miRNAs in regulating development and differentiation, multiple researchers have investigated the relationship between miRNA and oncogenesis. Several publications report a correlation between aberrant miRNA expression and miRNA gene sites with cancer, including the following:

(1) Chronic lymphocytic leukemia (CLL) patients commonly exhibit a chromosomal abnormality at 13q14. No known tumor suppressor genes exist at this locus and no consistent involvement of any of the genes in the deleted region has been demonstrated. Interestingly, the genes for miR-15 and miR-16 are located at this locu
'"/>

Source:


Page: All 1 2 3 4 5 6 7 8 9 10 11 12 13

Related biology technology :

1. Novel MicroRNA Array Technology for Sensitive miRNA Profiling
2. Getting Started with MicroRNA Research
3. Stratagenes Human cDNA Microarrays: Perform Gene Expression Profiling and Discover New Genes
4. The Flexible matriXarray Chip System: A New Perspective for Probe Optimization in Gene-Expression Profiling
5. Ambion Offers Gene Expression Profiling Service
6. Total RNA from Whole Blood for Expression Profiling
7. Unmask Blood RNA for Gene Expression Profiling
8. Proteomics in Bladder Cancer Research: Protein Profiling of Bladder Squamous Cell Carcinomas, Rev C
9. Microgenomic Expression Profiling
10. Laser Capture Microdissection (LCM) and Expression Profiling of Long-Range Projection Neurons
11. A Novel Process for Gene Expression Profiling of Rat and Mouse Tissues from Formalin-Fixed Paraffin-Embedded Sections Using Microarrays
Post Your Comments:
(Date:9/30/2014)... (PRWEB) September 30, 2014 Proove ... medicine, is excited to announce a new genetic test ... The Proove Pain Perception Test will provide physicians ... and why pain tolerance levels are stratified between individuals. ... identify whether a person has a genetic predisposition that ...
(Date:9/30/2014)... Fla. , Sept. 30, 2014 CORD:USE ... pleased to announce that it has entered into an ... Inc. (Tianhe) which has licensed a series of patented technologies ... cells for possible clinical applications.  Tianhe is performing Phase ... and Spain using Tianhe,s Stem ...
(Date:9/30/2014)... September 30, 2014 OriginOil Inc. (OTC/QB: ... chemical-free process to clean up large quantities of water, ... Riggs Eckelberry reported on the launch of the company's ... site provided by partner STW Resources . , ... barrels per day (bpd) and achieved a 99.8% reduction ...
(Date:9/30/2014)... DEL MAR, Calif. , Sept. 30, 2014 /PRNewswire/ ... devices for women,s health announces its receipt of a ... The FemmyCycle menstrual cup has also received FDA clearance ... Health Canada, and the CE in Europe. This patent is ... design. In conjunction with this issuance, the company is releasing ...
Breaking Biology Technology:Proove Biosciences is Now Offering the Proove Pain Perception Genetic Test to Help Physicians Assess Patient Pain Tolerance Levels 2Proove Biosciences is Now Offering the Proove Pain Perception Genetic Test to Help Physicians Assess Patient Pain Tolerance Levels 3CORD:USE is Pleased to Announce it has Partnered with Tianhe Stem Cell Biotechnologies, Developer of Cord Blood Stem Cell Therapy Showing Promising Results in Clinical Trials for the Treatment of Diabetes and Autoimmune Diseases 2CORD:USE is Pleased to Announce it has Partnered with Tianhe Stem Cell Biotechnologies, Developer of Cord Blood Stem Cell Therapy Showing Promising Results in Clinical Trials for the Treatment of Diabetes and Autoimmune Diseases 3CORD:USE is Pleased to Announce it has Partnered with Tianhe Stem Cell Biotechnologies, Developer of Cord Blood Stem Cell Therapy Showing Promising Results in Clinical Trials for the Treatment of Diabetes and Autoimmune Diseases 4OriginOil, Inc. Report to Shareholders: Blue Gold in West Texas 2The FemmyCycle 2
... Emmy® and Tony® award-winning actress Blythe Danner and Amgen ... Reduce Fractures™, an educational campaign for women with postmenopausal ... Danner was diagnosed with postmenopausal osteoporosis at increased risk ... to educate themselves, take action and speak to their ...
... August 25, 2011 Amsterdam Molecular Therapeutics (Euronext: ... today reported its results for the first half year of ... , Glybera®: , Data showing Glybera produces significant reduction ... Atherosclerosis Society Meeting CHMP does not consider Glybera ...
... Biocept, Inc., a privately-held CLIA-certified laboratory testing company, focused ... (CTCs) in cancer patients, and Clarient, Inc. (a GE ... of a proprietary blood test for CTCs in breast ...  Clarient and Biocept will market and sell Biocept,s new ...
Cached Biology Technology:Award-Winning Actress Blythe Danner and Amgen Launch Act 2 Reduce Fractures™ Educational Campaign 2Award-Winning Actress Blythe Danner and Amgen Launch Act 2 Reduce Fractures™ Educational Campaign 3Award-Winning Actress Blythe Danner and Amgen Launch Act 2 Reduce Fractures™ Educational Campaign 4Award-Winning Actress Blythe Danner and Amgen Launch Act 2 Reduce Fractures™ Educational Campaign 5Award-Winning Actress Blythe Danner and Amgen Launch Act 2 Reduce Fractures™ Educational Campaign 6Award-Winning Actress Blythe Danner and Amgen Launch Act 2 Reduce Fractures™ Educational Campaign 7Amsterdam Molecular Therapeutics Reports Half-Year Results 2011 2Amsterdam Molecular Therapeutics Reports Half-Year Results 2011 3Amsterdam Molecular Therapeutics Reports Half-Year Results 2011 4Amsterdam Molecular Therapeutics Reports Half-Year Results 2011 5Amsterdam Molecular Therapeutics Reports Half-Year Results 2011 6Amsterdam Molecular Therapeutics Reports Half-Year Results 2011 7Amsterdam Molecular Therapeutics Reports Half-Year Results 2011 8Biocept and Clarient Announce Collaboration on First Test for Circulating Tumor Cells and HER2 Status in Breast Cancer Patients 2Biocept and Clarient Announce Collaboration on First Test for Circulating Tumor Cells and HER2 Status in Breast Cancer Patients 3Biocept and Clarient Announce Collaboration on First Test for Circulating Tumor Cells and HER2 Status in Breast Cancer Patients 4
(Date:9/30/2014)... that a new class of chemical compounds makes ... have also pinpointed the relevant target enzyme, thus ... , Researchers led by LMU,s Professor Angelika Vollmar ... Mnchen have identified a class of chemicals that ... against malignant tumors. The compound is itself non-toxic, ...
(Date:9/30/2014)... of perilous threats in today,s ocean. From overfishing ... fragile coral ecosystems are disappearing at unprecedented rates ... of corals surrounding the island of Moorea in ... tropical environment: coral guard-crabs. New research from the ... scientist Seabird McKeon and the museum,s predoctoral fellow ...
(Date:9/29/2014)... DC September 29, 2014 -- Plants have ... bacteria help the pants extract nutrients and defend ... pathogens from contaminating fruits and vegetables. Now, scientist ... bacteria inside of seeds; thus ensuring that sprouting ... from the University of Notre Dame, presented their ...
Breaking Biology News(10 mins):Cancer therapy: Driving cancer cells to suicide 2Smithsonian scientists discover coral's best defender against an army of sea stars 2Plants prepackage beneficial microbes in their seeds 2
... the past three decades, saturated fat has been considered a major ... persists in recommending reduced consumption of this macronutrient. However, new ... impact on CVD risk -- causing many to rethink the "saturated ... articles published in the October issue of Lipids ...
... New York, 1 October, 2010 A special article ... the recent Report of the 2010 Dietary Guidelines Advisory Committee ... to conform to the standards of evidence-based medicine, despite its ... The authors call the DGAC to task for failing to ...
... protein, STIM1, known to activate store-operated calcium channels has ... to researchers at Temple University. The researchers published ... Orai and Cav1.2 Channels, in the Oct. 1 issue ... Calcium, not just important for bones and teeth, is ...
Cached Biology News:Think saturated fat contributes to heart disease? Think again 2Think saturated fat contributes to heart disease? Think again 3Proposed dietary guidelines for Americans sharply debated 2Protein provides link between calcium signaling in excitable and non-excitable cells 2
Mouse monoclonal antibody raised against a partial recombinant EOMES. NCBI Entrez Gene ID = EOMES...
...
Rabbit polyclonal to MCP2 ( Abpromise for all tested applications). entrezGeneID: 6355 SwissProtID: P49873...
Mouse monoclonal antibody raised against a partial recombinant AATK. NCBI Entrez Gene ID = AATK...
Biology Products: