Navigation Links
MicroRNA Profiling by Array Analysis Reveals Critical BioMarkers

he miRNAs are homologous between species, suggesting that miRNAs represent an evolutionally conserved and critical regulatory pathway [11].

The best understood miRNA, lin-4, was identified in a C. elegans mutant screen designed to identify genes involved in developmental timing [reviewed in 12]. Cloning and analysis revealed that lin-4 is a small RNA that does not encode a protein [5]. The lin-4 miRNA accumulates during the first and second larval stages and triggers passage to the third larval stage by repressing the translation of at least two genes, lin-14 and lin-28 [13]. The activity of lin-4 depends on the partial homology of the miRNA to specific regions of the 3' untranslated regions (UTRs) of lin-14 and lin-28 mRNAs [5, 14]. Additional miRNAs have been functionally characterized (Figure 2). The range of miRNA functions affect early stage development, cell differentiation, and cell death, illustrating the critical roles that miRNAs play in cellular biology.


Figure 2. Function of Known miRNAs in Plants, Mouse, Fly, and Worm.

In animals, miRNAs are partially homologous to their mRNA targets. Using similar target selection criteria, a number of labs have predicted the mRNAs that miRNAs bind and regulate [15, 16]. Some of these putative miRNA target sites have been verified by monitoring target protein expression and using reporter constructs [15, 16].

Three critical points about miRNA function are:

(1) Each miRNA appears to regulate the translation of multiple gene
'"/>

Source:


Page: All 1 2 3 4 5 6 7 8 9 10 11 12 13

Related biology technology :

1. Novel MicroRNA Array Technology for Sensitive miRNA Profiling
2. Getting Started with MicroRNA Research
3. Stratagenes Human cDNA Microarrays: Perform Gene Expression Profiling and Discover New Genes
4. The Flexible matriXarray Chip System: A New Perspective for Probe Optimization in Gene-Expression Profiling
5. Ambion Offers Gene Expression Profiling Service
6. Total RNA from Whole Blood for Expression Profiling
7. Unmask Blood RNA for Gene Expression Profiling
8. Proteomics in Bladder Cancer Research: Protein Profiling of Bladder Squamous Cell Carcinomas, Rev C
9. Microgenomic Expression Profiling
10. Laser Capture Microdissection (LCM) and Expression Profiling of Long-Range Projection Neurons
11. A Novel Process for Gene Expression Profiling of Rat and Mouse Tissues from Formalin-Fixed Paraffin-Embedded Sections Using Microarrays
Post Your Comments:
(Date:10/25/2014)... (PRWEB) October 24, 2014 The ... the nation’s leading nonprofit authority on the use ... information exchange, announces its appointment of four new ... The workgroup leaders include:, ,     Peter ...     Erik Pupo, Specialist Leader, Deloitte Consulting LLP ...
(Date:10/25/2014)... (PRWEB) October 24, 2014 SonaCare ... focused ultrasound (HIFU) technology, announced that its Board ... as Chief Executive Officer, President and member of ... Dr. Carol will take-on expanded responsibilities within the ... as well as overseeing commercialization, manufacturing and finance. ...
(Date:10/25/2014)... , October 24, 2014 ... clinical-stage pharmaceutical company focused on the development of oral ... Nadav Kidron will present at FireRock Capital,s ... Capital,s Annual Micro-Cap Conference ,Date: Tuesday, October 28, 2014 ... New York City , ...
(Date:10/25/2014)... -- Investor-Edge has initiated coverage on the ... Vertex Pharmaceuticals Inc. (NASDAQ: VRTX ), Alexion ... Inc. (NASDAQ: PPHM ), and StemCells Inc. ... be accessed at: http://investor-edge.com/register . The ... a positive note as the Dow Jones Industrial Average ...
Breaking Biology Technology:WEDI Appoints Four New Security and Privacy Workgroup Co-chairs 2SonaCare Medical Board of Directors Appoints Dr. Mark Carol as CEO and President 2SonaCare Medical Board of Directors Appoints Dr. Mark Carol as CEO and President 3Oramed to Present at the FireRock Annual Micro-Cap Conference 2Oramed to Present at the FireRock Annual Micro-Cap Conference 3Biotech Stocks Technical Data - CytRx, Vertex Pharma, Alexion Pharma, Peregrine Pharma, and StemCells 2Biotech Stocks Technical Data - CytRx, Vertex Pharma, Alexion Pharma, Peregrine Pharma, and StemCells 3Biotech Stocks Technical Data - CytRx, Vertex Pharma, Alexion Pharma, Peregrine Pharma, and StemCells 4Biotech Stocks Technical Data - CytRx, Vertex Pharma, Alexion Pharma, Peregrine Pharma, and StemCells 5
... for Combining Efficiency and Renewables into an Energy ... recognized as an important component to America' energy ... discussion about including Energy Efficiency into what many ... Standards (RPS) . The whole idea being that ...
... Merge eFilm announced Wednesday that its net income ... same quarter last year. Though its net sales, at ... bottom line suffered because it paid more than twice ... quarter ending June 30 were $1,497,000, up from $1,400,000 ...
... partnership to provide travel solution , ,ROCHESTER, ... Concur Technologies, Inc. announced Monday the formation ... that will deliver benchmarking information to travel managers ... Runzheimer, an international consulting firm specializing in travel ...
Cached Biology Technology:Energy efficiency is no longer the Rodney Dangerfield of energy 2Energy efficiency is no longer the Rodney Dangerfield of energy 3Runzheimer and Concur develop travel management service 2
(Date:10/15/2014)... from strains of influenza virus increases with the latest ... complacent that the most substantial threats have been identified, ... arise when a new virus strain – against which ... in the human population. There have been five such ... which – the 1918 Spanish Flu – cost 50 ...
(Date:10/15/2014)... NXT-ID, Inc. (NASDAQ: NXTD and NXTDW) ... growing mobile commerce market releases photos and video of the recent ... October 13 th . Gino Pereira , ... angel investor Mr. Chad A. Verdi rang the bell.  ... his investors and employees "for their work and dedication in bringing ...
(Date:10/14/2014)... of years since T. rex took its ... scientists is breathing life back into dinosaurs using high-powered ... research has important implications for how dinosaurs used their ... sense of smell and cool their brains. , ... student Jason Bourke, lead author of the new study ...
Breaking Biology News(10 mins):Scientists 'must not become complacent' when assessing pandemic threat from flu viruses 2Photo Release: NXT-ID Inc. Rings Opening Bell of the NASDAQ Stock Market October 13th 2Photo Release: NXT-ID Inc. Rings Opening Bell of the NASDAQ Stock Market October 13th 3Dinosaur breathing study shows that noses enhanced smelling and cooled brain 2Dinosaur breathing study shows that noses enhanced smelling and cooled brain 3
... -- Scientists from The Forsyth Institute and Kings College, ... community, the Human Oral Microbiome Database, which provides descriptions ... commonly found in peoples mouths. Most bacteria living ... maintaining the health of teeth and gums, as well ...
... a biosensing nanodevice developed by Arizona State University ... airport security checkpoints and revolutionize health screenings for ... aureus (MRSA). Even more incredible than the ... the worlds tiniest rotary motor: a biological engine ...
... ... covert data -, LAKE WORTH, Fla., March 24 ... produce the,world,s first self-authenticating passport. It was introduced in the new,Belgian passport ... produces the Belgian passport,has added an optical decoder page in the passport ...
Cached Biology News:Scientists launch human oral microbiome database 2Biosensing nanodevice to revolutionize health screenings 2Biosensing nanodevice to revolutionize health screenings 3FCO and GSSC Team to Create World's First Self-Authenticating Passport 2
... work in collaboration with Pall Life Sciences ... in a variety of membrane chemistries. The ... on the Caliper TPWII, MultiDose, Prelude, and ... our Automation Certified Syringe Filters are available ...
... The Mini-PROTEAN 3 Dodeca cell with multi-casting ... of up to 12 mini format handcast (8.3 ... cm) gels. The cell requires 3.4-4.4 L of ... cooling coil that attaches to an external refrigerated ...
...
... has been developed to significantly increase the ... Stability is increased at room temperature ... This product is subjected to 0.2 ... azide. This formulation insures consistently high ...
Biology Products: