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MicroRNA Profiling by Array Analysis Reveals Critical BioMarkers

. A number of miRNAs appear to be routinely under- or over-expressed in tumors. For instance, miR-126, miR-143, and miR-145 were expressed at significantly lower levels in more than 80% of the tumor samples compared to their associated normal tissues. miR-21 was found to be over-expressed in 80% of the tumor samples. These miRNAs likely represent biomolecules that directly or indirectly influence oncogenesis. In addition, several miRNAs were found to be differentially expressed in specific types of cancers, suggesting that there are disease-specific miRNAs.


Figure 6. miRNA Expression Profiles of Tumor vs Normal Adjacent Tissue from Cancer Patients. The miRNA expression profiles (y axis) in tumor vs normal adjacent human tissues (x axis) were compared for 19 cancer patients. Green in the heat map shows miRNAs that are down-regulated in the tumor sample relative to the normal adjacent tissue sample, and red shows miRNAs that are up-regulated in the tumor sample relative to the normal adjacent tissue sample.


As with the normal tissue samples described above, we used a secondary method of detection to confirm the miRNA array results for a few of the more interesting miRNAs (Figure 7). The samples from the two lung cancer patients that provided the most total RNA were analyzed for expression of miR-16, miR-21, miR-143, miR-145, and let-7. As was observed in the comparisons of the miRNA expression profiles in the normal samples, the quantitative data from the miRNA array procedure were very similar to the secondary analysis, again, validating the procedure.

Figure 7. Independent Verification of miRNA Arra
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