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MicroRNA Profiling by Array Analysis Reveals Critical BioMarkers


Jaclyn Shingara, Kerri Keiger, Ila Wolf, Jeffrey Shelton, Emmanuel Labourier, and David Brown
R&D Division, Ambion, Inc.

MicroRNAs (miRNAs) are small, siRNA-like molecules, encoded in the genomes of plants and animals, that regulate the expression of genes by binding to and modulating the translation of specific mRNAs. Published reports indicate that the expression levels of miRNAs vary between tissues and developmental stages, and that several miRNAs appear to be down-regulated in patients with chronic lymphocytic leukemia, colonic adenocarcinoma, and Burkitt's lymphoma [1-3]. Viral miRNAs also appear to play roles in infection [4].

Ambion scientists have developed a microarray analysis process that makes it possible to compare the miRNA expression profiles of different tissue and cell samples. This process has been used to analyze samples from different human organs as well as tumor and normal adjacent tissues from patients with lung, colon, breast, prostate, bladder, thyroid, and pancreatic cancers. The miRNA array procedure uses the mirVana miRNA Probe Set, to create miRNA arrays, and the mirVana miRNA Labeling Kit, to label samples for subsequent miRNA array hybridization. This procedure is highly sensitive, accurate, and reproducible, providing an effective tool for evaluating miRNA expression during development, differentiation, viral infection, or
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