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Kodak in vivo imaging system: precise coregistration of molecular imaging with anatomical X-ray imaging in animals

signal over the surrounding background signal. Dark-field contrast, however, does not typically provide the appropriate contextual anatomic information for useful localization of the molecular imaging signals within the animal. Limited anatomic context of darkfield agents has been provided using digital imaging overlay techniques in which the dark-field contrast is superimposed on a reflection image of an experimental animal.

Although the overlay methods are beneficial, repeated imaging of the same animal in different imaging sessions often results in misinterpretation of the signal localization as animal repositioning is difficult. The white-light reference image may be suitable for localization of large tumor masses, but lacks the anatomical context required for repeatedly localizing smaller signals of interest and/or mapping the molecular signals to bones or other anatomical structures within the animal.

Hoping to realize the full potential of the dark-field molecular imaging agents, researchers are beginning to apply multimodal instrumentation that combines dark-field contrast with penetrating radiographic anatomical imaging in one system.


Kodak Image Station In-Vivo F/FX
Kodak Molecular Imaging Systems has recently introduced a line of in vivo small-animal imaging systems, including a model that allows the capture of X-ray images. These X-ray images provide the detailed penetrating anatomical guideposts that greatly enhance the localization of the in vivo optical or radioisotopic molecular imaging agents.

The product line consists of the Kodak Image Station In-Vivo F and the Kodak Image Station In-Vivo FX. The In-Vivo F allows for very high resolution,
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