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Kodak in vivo imaging system: precise coregistration of molecular imaging with anatomical X-ray imaging in animals

Kodak Molecular Imaging Systems introduces a line of small-animal in vivo imaging instruments that provide a new level of molecular signal localization in live animals. The Image Station In-Vivo FX allows precise multi-modal coregistration of optical or radioisotopic molecular images with high-resolution anatomical X-ray images in animals


Traditional research on disease mechanisms using animal models has relied mainly on the detection of morphological changes of the diseased tissues, with physical measurements and anatomical imaging or on the excision and pathological study of the tissues of interest. These methods often require long time periods for measurable changes to occur and require a large number of animal cohorts as multiple animals are often sacrificed at each time point for histological testing.

Over the last few years, exciting new molecular imaging agents have emerged from research laboratories that allow highly specific fluorescence-, luminescence- and radioisotope-based imaging of disease processes at the molecular level within living animals. These in vivo molecular imaging agents provide the potential for rapid detection of specific molecular and metabolic changes within target tissues in animals (or humans) long before morphologic changes can be detected. In addition, these molecular changes can be monitored in vivo without sacrificing the animal, resulting in lower cost, time savings and improved data by using the same live animal for continued studies.


The need for multimodal imaging
One major advantage of optical molecular imaging over anatomical imaging is the use of dark-field imaging methods that allow high levels of target
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