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Increased Analyte Sensitivity through the Utility of Enhanced Mass-Resolution on the FinniganTSQ Quantum Discovery

A)
Source: ESI Mode
Ion Polarity: Positive
Ion Transfer Tube Temperature: 350C
Spray Voltage: 3500 V
Sheath/Auxiliary Gas: Nitrogen
Sheath Gas: 80 arbitrary units
Auxiliary Gas: 20 arbitrary units
Collision Gas Pressure: 1.3 mTorr

The SRM conditions for compound A were as follows:
Parent m/z: 473.28
Product m/z: 456
Scan Width: 1 u
Scan Time: 0.2 s
Collision Energy: 20 eV
Q1 Peak Width (unit mass-resolution): 0.7 u FWHM
Q1 Peak Width (enhanced mass-resolution): 0.2 u FWHM
Q3 Peak Width: 0.7 u FWHM

The internal standard SRM conditions were as follows:
Parent m/z: 544.40
Product m/z: 306
Scan Width: 1 u
Scan Time: 0.2 s
Collision Energy: 28 eV
Q1 Peak Width (unit mass-resolution): 0.7 u FWHM
Q1 Peak Width (enhanced mass-resolution): 0.2 u FWHM
Q3 Peak Width: 0.7 u FWHM

Results and Discussion
The LC/ESI-SRM chromatograms for blank plasma spiked with the internal standard, collected on the Finnigan TSQ Quantum Discovery operating in unit mass-resolution mode (Q1, 0.7 u FWHM), are shown in Figure 1. The arrow shown in Figure 1 indicates the expected retention time of compound A (t = 1.2 min). It can be seen that significant background interference elutes at the same retention time as compound A in the blank plasma (Figure 1). However, when the same blank plasma sample was analyzed by the Finnigan TSQ Quantum Discovery operating at enhanced mass-resolution (Q1, 0.2 u FWHM), the background interference at t =1.2 min was greatly reduced, as shown in Figure 2. The reduction in background noise is a consequence of the added specificity afforded to
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