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Increased Analyte Sensitivity through the Utility of Enhanced Mass-Resolution on the FinniganTSQ Quantum Discovery

Chromatography and Mass Spectrometry Application Note

Key Words Sensitivity Quantitation Finnigan TSQ Quantum Discovery Enhanced Mass- Resolution

Xiaoying Xu1, Gary Paul2, Qiao Zhou1, Gregory Tucker1, and Walter Korfmacher1
1 Department of Drug Metabolism and Pharmacokinetics, Schering-Plough Research Institute, Kenilworth, NJ, USA; 2 Thermo Electron Corporation, Somerset, NJ, USA

Overview
Comparison of the limit of quantitation (LOQ) of a drug discovery compound in plasma at unit mass-resolution and enhanced mass-resolution on the Finnigan TSQ Quantum Discovery triple quadrupole mass spectrometer.

Introduction
Recent technological advances in atmospheric pressure ionization (API) techniques and instrumentation are revolutionizing the quantitation of pharmaceutical products.[1] The benchtop Finnigan TSQ Quantum Discovery provides a unique enhanced mass-resolution capability for a triple quadrupole mass spectrometer.[1-6] The utility of enhanced mass-resolution on the Q1 mass analyzer for parent ion selection in the selected reaction monitoring (SRM) experiment has been investigated in previous quantitation studies on the Finnigan TSQ Quantum Discovery. Improved analyte sensitivities were achieved at enhanced mass-resolution, relative to the typical unit mass-resolution mode of a triple quadrupole mass spectrometer.[2-6] These improvements were simply accomplished through the mass separation of the analyte of interest from isobaric matrix/chemical interferences, using the additional resolving power of the quadrupole mass analyzer.

In order to further investigate the benefits of enhanced mass-resolution on the Finnigan TSQ Quantum Discovery, the sensitivity of a drug discovery compound, present in a min
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