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Improved Quantitative Selectivity of Clenbuterol in Human Urine using ,,, High Resolution on the TSQ Quantum Mass Spectrometer

compound containing Chlorine, such as Clenbuterol, and hence improve the selectivity of the quantitative assay. TSQ Quantum Tune View Optimisation of Clenbuterol Clenbuterol (C12H18Cl2N2O, molecular weight 276.08) was infused, 0.1 ng/L, into the ESI source and the four most abundant product ions for the MS/MS breakdown were determined using the automated compound optimisation procedure in the TSQ Quantum (Figure 2).

The transition yielding the most abundant product ion (m/z 203.0) was selected for the analysis of Clenbuterol. Figure 2: Automated optimisation of MS/MS parameters for Clenbuterol Experimental Conditions Sample Preparation: Human urine extracts were prepared using a Solid Phase Extraction technique (Varian Bond-Elut LRC-18, methanol as eluent). The extracted urine was spiked with Clenbuterol in the concentration range 0.1, 0.5, 1, 5, 10, 50 and 100 pg/L for the calibration standards. No internal standard was used in this study.

Sample Analysis: The spiked urine extracts were chromatographed (Thermo Finnigan Surveyor System) on a C18 Elite 100 mm 2.1 mm column (Thermo Hypersil-Keystone) at a flow rate of 300 L/min with a linear gradient of 10% solvent B (Methanol/Ammonium acetate [10mM] 90/10 v/v) to 100% B over 5 minutes. Solvent A was Ammonium acetate (10 mM). The calibration standards were injected in duplicate at volumes of 10 L. MS Conditions: Mass spectrometer: Thermo Finnigan TSQ
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