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Improved Quantitative Selectivity of Clenbuterol in Human Urine using ,,, High Resolution on the TSQ Quantum Mass Spectrometer

Mark Churchill1, Mark Harrison1, John Henninge,2 and Hanne Lund2

1 Thermo Finnigan, Stafford House, 1 Boundary Park, Boundary Way, Hemel Hempstead, HP2 7GE, UK;
2 Aker University Hospital, Hormone Laboratory, Section for Doping Analysis,Trondheimsveien, N-0514, Oslo, Norway

Monitoring Clenbuterol in Humans

The data presented here was acquired on a Thermo Finnigan TSQ Quantum mass spectrometer Introduction Clenbuterol (Figure 1) is a beta-2-adrenergic agonist, an effective bronchodilator drug used for the treatment of human asthma. Clenbuterol also relieves bronchial airway smooth muscle contractions caused by Chronic Obstructive Pulmonary Disease (COPD) and allergyinduced respiratory distress.

Clenbuterol also has significant anabolic effects and could be used as a drug of abuse in athletes and livestock for its muscle growth stimulant properties. It also raises the body temperature and hence facilitates fat tissue catabolism. Due to Clenbuterol having these anabolic properties, it must be routinely monitored in biological samples by veterinary and human doping control laboratories. Figure 1: Clenbuterol Goal One of the limitations to quantitation is the unequivocal identification of analytes in biological samples due to endogenous matrix interferents.

This report describes the use of high resolution on the TSQ Quantum to exploit the negative mass defect of a
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