Navigation Links
Identification of Phase I and Phase II Metabolites of Buspirone on the Q TRAP LC/MS/MS System

cedented selectivity

Broad linear dynamic range provides true triple quadrupole quantitation performance and enhances identification of ions in complex matrices

Information-rich MS/MS and MS3 spectra with important low mass structural ions provide confidence in results

Metabolite ID application software makes it easy to go straight to the answers

Experimental Conditions

Rat liver microsomal incubate samples were injected on a Hypersil- Betasil C18 column (1 x 100 mm). Samples were eluted using Shimadzu 10 AD pumps with a gradient of water/methanol, from 10 to 90% methanol over 10 minutes at a flow rate of 70 μL/min. Direct injection (5 μL) on column was performed using a PE Series 200 autosampler. A TurboIonSpray source was operated at 350 C on the Q TRAP system.

Results and Discussion

The new Q TRAP LC/MS/MS system combines superior ion trap capabilities with triple quadrupole performance to provide a new level of performance and versatility in LC/MS for metabolite identification. The patented hybrid linear design enhances sensitivity, resolution, and duty cycle for MS and MS/MS full scan modes, and combines these features with the linear dynamic range and scan functions of a triple quadrupole instrument.

Add Metabolite ID application software and get automated data acquisition and processing, with a range of options to ensure maximum productivity. Metabolite ID application software leverages the Q TRAP system technology and IDA to provide rapid, high-confidence results in the fewest number of experiments.

Metabolite ID:

Identifies predefined and userdefined Phase I and Phase II transformations

Detects unexpected metabolites by recognition of isotope ratio patterns

Trigger
'"/>

Source:


Page: All 1 2 3 4 5

Related biology technology :

1. Identification of Differentially Expressed Gene Products with the CastAway System*
2. An Optimal DNA Microarray Substrate for the Identification of Fetal and Somatic Liver Stem Cells of the Rat
3. Identification of Low-Level Oxidation Products in Calmodulin Using NanoSpray Ion Trap Mass Spectrometry
4. Detection and Identification of Phosphorylation Sites in Proteins Using LC/MS/MS with Neutral Fragment Loss Mapping
5. Protect RNA and Improve Target Cell Identification
6. Identification of Disease Causing Mutations in Phenylketonuria by Denaturing Gradient Gel Electrophoresis Using the DCode System
7. Identification of Nonspecific Products Using Melt-Curve Analysis on the iCycler iQ Detection System, Rev A
8. Identification of cells in S phase using the Cell Proliferation Fluorescence Kit and IN Cell Analyzer 1000
9. Identification of Insecticides and Herbicides by LC/MS/MS Using the API 2000 LC/MS/MS System
10. ESR1 Gene Expression in Oncology and Metabolic Diseases Using the ASCENTATM System Target Validation and Identification of Novel Disease Indications
11. Protocol for RNA Isolation Using TRIzol Reagent with Phase Lock Gel-Heavy
Post Your Comments:
(Date:12/24/2014)... Md. , Dec. 24, 2014  United ... today that Medtronic, Inc. (NYSE: MDT ... the U.S. Food and Drug Administration (FDA) for ... implantable drug infusion system (including a newly developed ... (treprostinil) Injection delivered intravenously to patients with ...
(Date:12/24/2014)... “Preparative & Process Chromatography Market ... (Columns, Solvents, Buffers, Valves, Guages, Seals), Accessories, Services, ... Forecasts to 2019” provides a detailed overview of ... trends, and strategies impacting the preparative and process ... of the revenue and share analysis. , ...
(Date:12/24/2014)... On Friday, December 19, 2014, ... Omnibus and Continuing Resolution Appropriations Act of 2015, ... condition eligible to receive funding through the Congressionally ... Department of Defense (DoD). The Hydrocephalus Association (HA), ... Hill, is celebrating this victory for the over ...
(Date:12/24/2014)... The report expects global cell isolation and expansion market ... a carefully analyzed data about the vital drivers, restraints, ... Full Copy of Report @ http://bit.ly/1yUxy0T , ... expansion will keep witnessing growth at an impressive CAGR ... driven by rapid technological advancements, government funding and investments, ...
Breaking Biology Technology:United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 3United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 4Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 2Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 4Rare Brain Condition Now Eligible for Department of Defense Research Dollars 2The Cell Expansion Market is Expected to Reach $14.8 billion by 2019 - New Research Report by MarketsandMarkets 2The Cell Expansion Market is Expected to Reach $14.8 billion by 2019 - New Research Report by MarketsandMarkets 3
... The Netherlands , April 27, 2010 Immunovo,BV, a ... recent insights in oncology to develop novel,therapeutics, secures seed funding from Dutch ... , ... - Immunovo BV, a new,biotechnology company developing a novel technology platform ...
... Biotechnology Product Projects , , ... PARK, Md. , April 27 The Maryland Biotechnology Center, the ... and strengthen the state,s bioscience community, has enabled biotechnology product development projects to ... support. , , , ...
... Gage R&R of ... ... reports of quality failures in both the medical device and automotive industries, InterTech Development Company ... entire assembly and test systems, not just instruments. Having been called in to solve ...
Cached Biology Technology:Immunovo BV- A New Biotechnology Company is Announced 2Maryland Biotechnology Center Supports $270,000 in MIPS Projects 2Maryland Biotechnology Center Supports $270,000 in MIPS Projects 3Maryland Biotechnology Center Supports $270,000 in MIPS Projects 4Maryland Biotechnology Center Supports $270,000 in MIPS Projects 5InterTech Service to Counter Widely Reported Problems in Automotive, Medical Device and Other Industries Requiring Rigorous Quality Standards 2
(Date:12/17/2014)... 2014 The Defense Logistics Agency is ... detect and prevent counterfeit microcircuits from entering into ... started performing an in-house microcircuit anti-counterfeit initiative dubbed ... of purchased microcircuits while increasing their reliability throughout ... will be conducted at DLA,s Electronics Product Test ...
(Date:12/17/2014)... 2014 Research and Markets ( ... "Global Chemical Sensor Market 2015-2019" report ... http://photos.prnewswire.com/prnh/20130307/600769 One major trend upcoming ... medical sensors in biomedical applications. Chemical sensors help ... correct diagnosis during surgical procedures. The Global Chemical ...
(Date:12/11/2014)... DUBLIN , Dec. 09, 2014 Research ... http://photos.prnewswire.com/prnh/20130307/600769 ( http://www.researchandmarkets.com/research/twhjll/biometrics_market ) ... Market in the APAC Region 2015-2019"  report to ... emerging in this market is advances in technology. ... to upgrade biometric solutions to the latest standard ...
Breaking Biology News(10 mins):Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 3Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2
... one of the immune system,s key weapons against infection ... biliary atresia in infants, a disease where blocked bile ducts ... Cincinnati Children,s Hospital Medical Center also report that blocking a ... damage and may be a way to treat the most ...
... , , , ... Shopper Insights Conference, Perception Research Services International (PRS) and EmSense ... packaging research studies. The companies presented findings from a ... EmSense,s EmGear(TM) EEG unit to link package viewing patterns with ...
... The new research study led by scientists at ... that by improving overall ocean health, corals are better ... rising sea temperatures force corals to expel their symbiotic ... that is expected to increase in frequency as global ...
Cached Biology News:Scientists link immune system's natural killer cells to infant liver disease 2PRS And EmSense Partner To Integrate Bio-Sensory Measures In Packaging Research Studies 2Scripps-led study shows ocean health plays vital role in coral reef recovery 2
Bethyl Laboratories packages antibodies, conjugates and calibrators to provide quantitative ELISA kits. Each kit contains the following components, sufficient for 1000 single well assays....
Request Info...
Bethyl Laboratories packages antibodies, conjugates and calibrators to provide quantitative ELISA kits. Each kit contains the following components, sufficient for 1000 single well assays....
... and IHC Protocol Development ,Antibody Titer ... in Animal or Human Cells and ... and Tissues ,Peroxidase, Alkaline Phosphatase, Immunogold, ... Electron Microscopy ,Protein Localization in Transgenic ...
Biology Products: