Navigation Links
Identification of Phase I and Phase II Metabolites of Buspirone on the Q TRAP LC/MS/MS System

cedented selectivity

Broad linear dynamic range provides true triple quadrupole quantitation performance and enhances identification of ions in complex matrices

Information-rich MS/MS and MS3 spectra with important low mass structural ions provide confidence in results

Metabolite ID application software makes it easy to go straight to the answers

Experimental Conditions

Rat liver microsomal incubate samples were injected on a Hypersil- Betasil C18 column (1 x 100 mm). Samples were eluted using Shimadzu 10 AD pumps with a gradient of water/methanol, from 10 to 90% methanol over 10 minutes at a flow rate of 70 μL/min. Direct injection (5 μL) on column was performed using a PE Series 200 autosampler. A TurboIonSpray source was operated at 350 C on the Q TRAP system.

Results and Discussion

The new Q TRAP LC/MS/MS system combines superior ion trap capabilities with triple quadrupole performance to provide a new level of performance and versatility in LC/MS for metabolite identification. The patented hybrid linear design enhances sensitivity, resolution, and duty cycle for MS and MS/MS full scan modes, and combines these features with the linear dynamic range and scan functions of a triple quadrupole instrument.

Add Metabolite ID application software and get automated data acquisition and processing, with a range of options to ensure maximum productivity. Metabolite ID application software leverages the Q TRAP system technology and IDA to provide rapid, high-confidence results in the fewest number of experiments.

Metabolite ID:

Identifies predefined and userdefined Phase I and Phase II transformations

Detects unexpected metabolites by recognition of isotope ratio patterns

Trigger
'"/>

Source:


Page: All 1 2 3 4 5

Related biology technology :

1. Identification of Differentially Expressed Gene Products with the CastAway System*
2. An Optimal DNA Microarray Substrate for the Identification of Fetal and Somatic Liver Stem Cells of the Rat
3. Identification of Low-Level Oxidation Products in Calmodulin Using NanoSpray Ion Trap Mass Spectrometry
4. Detection and Identification of Phosphorylation Sites in Proteins Using LC/MS/MS with Neutral Fragment Loss Mapping
5. Protect RNA and Improve Target Cell Identification
6. Identification of Disease Causing Mutations in Phenylketonuria by Denaturing Gradient Gel Electrophoresis Using the DCode System
7. Identification of Nonspecific Products Using Melt-Curve Analysis on the iCycler iQ Detection System, Rev A
8. Identification of cells in S phase using the Cell Proliferation Fluorescence Kit and IN Cell Analyzer 1000
9. Identification of Insecticides and Herbicides by LC/MS/MS Using the API 2000 LC/MS/MS System
10. ESR1 Gene Expression in Oncology and Metabolic Diseases Using the ASCENTATM System Target Validation and Identification of Novel Disease Indications
11. Protocol for RNA Isolation Using TRIzol Reagent with Phase Lock Gel-Heavy
Post Your Comments:
(Date:10/13/2008)...e/ -- Larry Corey, M.D., senior vice,president and... Institute,at Fred Hutchinson Cancer Research Cent...e prestigious Institutes of Medicine (IOM)., Elec...onors in the,fields of health and medicine and rec...ing professional achievement and commitment to,ser...
(Date:10/13/2008)...Xinhua-- China Medicine,Corporation (... Company"),a leading distributor and developer of..., traditional Chinese medicines ("TCM"), nutrition...edical formulations in the,People,s Republic of Ch...ry, Konzern U.S Holding Corporation, announced tod...
(Date:10/13/2008)...3 /- WebLOQ, Inc., the emerging,leade...ant eBusiness and,data-in-motion communications, t...eployed the WebLOQ ePrivacy solution in their stat...th their healthcare partner, the,Monterey Peninsul...mplemented WebLOQ,s hosted, on demand ePrivacy tec...
(Date:10/12/2008)...e-FirstCall/ -- Cell Therapeutics, Inc.,(CTI) (Nas... three upcoming,investor conferences. The conferen...an Francisco in October, the 19th Annual Oppenheim... Acumen BioFin Rodman & Renshaw,Healthcare Confere...entations will be webcast live with slides, and av...
Breaking Biology Technology:China Medicine to Showcase 'Bethin' Weight Loss Product at 2008 Natural Products Expo East Trade Show 2China Medicine to Showcase 'Bethin' Weight Loss Product at 2008 Natural Products Expo East Trade Show 3Monterey Spine and Joint Deploys WebLOQ ePrivacy Solution for HIPAA Compliant Health Information Exchange 2Monterey Spine and Joint Deploys WebLOQ ePrivacy Solution for HIPAA Compliant Health Information Exchange 3Cell Therapeutics, Inc. (CTI) to Present at Three Upcoming Investor Conferences 2
...s, these should be heady days for American manufac...ufacturing jobs were lost, the economy is back, ma...ck. , ,Yet there is a sense of unease linked to w...ge earners make 1/20 th of what their American co...centage point advantage in gross margin, and where...
... the Midwest looking for new ways to increase sale...oaches of bringing in developers to develop open l...g to entice businesses with tax incentives and red...cipalities. , ,This is a common practice with eve...incentives and adjusting building codes to help sh...
...y remains pervasive in American and foreign busine... cracking down, and violators have been paying a s... software programs in use in the United States is ...copyright owners are increasingly taking measures ... for those who report cheaters. , ,And that means...
... information technology consolidation projects bou...g? , ,Matt Miszewski, the CIO for the State of Wis...ving with IT consolidation are not unusual for lar...t point, especially from other government CIOs, bu...tright failures really inevitable? , ,Christopher ...
Other Biology Technology:Manufacturers advised to redesign customer relations 2Manufacturers advised to redesign customer relations 3Electronic signs for municipalities: Las Vegas or lost revenues? 2Electronic signs for municipalities: Las Vegas or lost revenues? 3Electronic signs for municipalities: Las Vegas or lost revenues? 4Companies are still taking software license 2Companies are still taking software license 3State IT failures are not inevitable 2State IT failures are not inevitable 3State IT failures are not inevitable 4State IT failures are not inevitable 5
(Date:10/13/2008)...w study demonstrates that the embryonic mouse hear...omenon previously observed only in non-mammalian s...he October 14th issue of the journal Developmenta...ential of the embryonic heart to replace diseased ...hy cells. , Disorders of the mitochondria, a cel...
(Date:10/12/2008)... Scientists have found a new possible explanation ...ay gain protection against the spread of cancers. ...pectin, found in all fruits and vegetables, binds ... protein that plays a role in all stages of cancer...effects of foods are based on population studies,"...
(Date:10/12/2008)...ns have a built-in weapon against HIV, but until r..., A study published online by the journal Nature...enzyme known as APOBEC-3G and suggests new direct...t in every human cell. It is capable of stopping H...ovirus transcribes its RNA into viral DNA. , The...
(Date:10/10/2008)...ESDA, MD October 7, 2008 The world,s top scienti...ll gather in Philadelphia to present their latest ...e,American Society of Human Genetics (ASHG) from ...15, 2008, at the Pennsylvania Convention Center.,... membership organization for human genetics,speci...
Breaking Biology News(10 mins):Embryonic heart exhibits impressive regenerative capacity 2Pectin power 2Body's anti-HIV drug explained 2The American Society of Human Genetics hosts 58th Annual Meeting in Philadelphia 2The American Society of Human Genetics hosts 58th Annual Meeting in Philadelphia 3The American Society of Human Genetics hosts 58th Annual Meeting in Philadelphia 4The American Society of Human Genetics hosts 58th Annual Meeting in Philadelphia 5AT 26T Establishes New Network Services for Leading Medical Liability Insurer 1674 1AT 26T Establishes New Network Services for Leading Medical Liability Insurer 1674 2AT 26T Establishes New Network Services for Leading Medical Liability Insurer 1674 3AT 26T Offers Network Industry First RFID Solution for Health Care Organizations 1671 1AT 26T Offers Network Industry First RFID Solution for Health Care Organizations 1671 2AT 26T Offers Network Industry First RFID Solution for Health Care Organizations 1671 3Flu virus trots globe during off season 1668 1Flu virus trots globe during off season 1668 2Flu virus trots globe during off season 1668 3Schooner Healthcare Services LLC Announces New Leadership Team 1665 1Schooner Healthcare Services LLC Announces New Leadership Team 1665 2
...d today released the results of a field survey fro...as significantly reduced Borneo,s population of Su...ive in the "Heart of Borneo," a region covered wit...evidence of at least 13 rhinos in the interior of ...It was conducted in 2005 by teams of more than 100...
...luenza virus, commonly known as "bird flu," is a h... far, its spread to humans has been limited, with ...eaths in Indonesia, Vietnam, Thailand, Cambodia, C...ding to the World Health Organization ( www.who.in...s in poultry and wild birds, further human cases a...
...e shed new light on the mechanism of nerve cell gr...r "motor" protein, myosin-II, according to an arti...s nerve cells develop or attempt to recover after ...extensions that act as environmental sensors. Grow... advance of the nerve cells and it has long been k...
...y proteins has been found to constitute one of the...n nature, researchers have discovered. The enginee...ard Hughes Medical Institute say their discovery c...cesses within the living cell. The discovery also ...r "gate-opening springs" in tiny nanomachines. ,...
Other Biology News:Rhinos clinging to survival in the heart of Borneo, despite poaching 2Minor mutations in avian flu virus increase chances of human infection 2Minor mutations in avian flu virus increase chances of human infection 3A new focus for the mechanism of nerve growth 2Protein 'nanosprings' most resilient found in nature 2Protein 'nanosprings' most resilient found in nature 3Protein 'nanosprings' most resilient found in nature 4
... Biometra TProfessional Thermocycler combines top ...ver block achieves high speed and unparalleled tem...hical display providing programming in a spreadshe...Performance Smart Lid opens on the push of a butto...
...e VSOS-4 Orbital Shaker is designed to be a solid,...iform motion that is both mixing and vortexing in ...ooth, quiet, reproducible and uniform orbital shak...oratory applications such as cell/tissue culture, ...
Preparation TW--Compatibility: no end cap seals -Hybridization Tube for Hybrigene -Comp Dim: 240 80 mm -Material: borosilicate glass -Mfr Desig: Techne FHB-15
...Elute™ Agarose Spin Columns are designed for...DNA from agarose gels. The DNA band is excised fro...Embedded within the base of the column are a serie...mpurities back while allowing DNA to selectively p...
Biology Products: