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IMPROVE SILENCING SUCCESS: siRNAs THAT WORK BETTER!

into libraries. Ambion's first siRNA libraries include the Silencer Kinase siRNA Library and the Silencer G-protein coupled receptors (GPCR) siRNA Library. Other libraries are under development. If there is a particular library that you are interested in, send us an email at libraries@ambion.com.


siRNAs Targeting 597 Human Kinases
The Silencer Kinase siRNA Library includes nearly 1800 siRNAs -- three individual siRNAs targeting each of 597 human kinases. All of the siRNAs have been designed using the Cenix algorithm. In addition, 528 of the siRNAs targeting 231 of the kinases are validated and have been functionally verified to reduce target mRNA levels by >70%. Subsets of the library, divided by kinase functional class, are also available.


siRNAs Targeting 441 G-protein Coupled Receptors (GPCRs)
The Silencer GPCR siRNA Library includes three siRNAs targeting each of 441 human non-olfactory GPCRs for a total of >1400 siRNAs. Like the siRNAs in the Silencer Kinase siRNA Library, each of the siRNAs has been designed using the Cenix algorithm.


Silencer Kinase siRNA Library in Action
With libraries of functional siRNAs, you can readily screen for phenotypes resulting from gene-specific inhibition, thus accelerating pathway analysis or target identification and validation studies. Cenix recently u
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Related biology technology :

1. GENE SILENCING WITH PCR PRODUCTS
2. Silencer Validated siRNAs
3. Cenix-Designed siRNAs for 95% of Human and Mouse Genomes
4. Five Ways to Produce siRNAs
5. Efficient Delivery of siRNAs to Human Primary Cells: Electroporation vs. Chemical Transfection
6. Optimizing Chemical Transfection and Electroporation of siRNAs
7. Delivering siRNAs to Difficult Cell Types
8. Matched siRNAs and Assays: Ambion + Applied Biosystems = RNAi Success
9. Deliver siRNAs Into Primary Cells
10. Optimize Transfection of siRNAs for RNAi
11. RNAi as a Tool for Mammalian Gene Analysis: Applications of siRNAs
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