( ...)IMPROVE SILENCING SUCCESS: siRNAs THAT WORK BETTER!

• High Quality Custom Synthesis of siRNAs
• Cenix Pre-designed siRNAs to Human, Mouse, and Rat Genomes
• Silencer Validated siRNAs
• Silencer siRNA Libraries

Superior siRNA Design Combined with High Quality Custom RNA Synthesis by Ambion
Finding a highly effective siRNA can be a time consuming and labor intensive process, particularly if you are using publicly available design tools. Ambion and Cenix BioScience have partnered to provide you with high quality, effective siRNAs so you no longer need to design your own. Cenix has developed a powerful siRNA design algorithm that yields a high percentage of potent and specific siRNA sequences, and has used this algorithm to pre-design siRNAs targeting >98% of all human, mouse, and rat genes in the RefSeq database. With a major expansion of Ambion's chemical synthesis facilities, Ambion can now synthesize these made-to-order siRNAs in a variety of scales with your choice of purification options.

Design is Key to Success
To develop a rational siRNA design algorithm, Cenix and Ambion tested multiple siRNAs targeting hundreds of different human genes. The effective and ineffective siRNA sequences were used to judge the impact of a number of siRNA characteristics on their potency, including melting temperature of the duplex, nucleotide content of the 3' overhangs
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