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Human stem cells stand on their own

A colony of human embryonic stem cells grown over a period of 10 months in 2004 in the absence of mouse feeder cells. The cell nuclei are stained green; the cell surface appears in red. Photo courtesy of Ren-He Xu/UW-Madison.
Madison, Wis. Tackling a pressing and controversial technical barrier in stem cell biology, scientists at the WiCell Research ......

Full article >>> "It also significantly reduces the daily labor of preparing the feeder cell-conditioned medium."

"It is important that the culture of human ES cells be simplified so that the average scientist can use them without extensive prior training," says James Thomson, a UW-Madison professor of anatomy and a co-author of the Nature Methods paper. "This development is a good step in that direction.......

Full article >>> nstance.

Unexpectedly, Xu found that the presence of serum replacement promoted stem cell differentiation. Digging deeper, he found that serum replacement mimics the activity of bone morphogenetic protein (BMP), a molecule known to kick-start embryonic development, or in this case, cell differentiation.

If serum replacement triggers stem cell differentiation, Xu deduced, there mu......

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'"/> By Paroma Basu 02/17/05

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