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Highly Sensitive microRNA Array Performance

human tissues that were analyzed had a unique pattern of miRNA expression (Figure 5). Hierarchical clustering showed that miRNA profiles were similar between related tissues and distinct between unrelated tissues, e.g. heart and skeletal muscle miRNA profiles were very similar; and expression in digestive tract tissues clustered, as did that of reproductive organ tissues. Interestingly, the brain miRNA profile was clearly distinct from the other tissues analyzed. The observation that adult tissues possessed unique miRNA profiles suggests that miRNAs function in tissue differentiation. Furthermore, similar miRNA profiles among related tissues provides additional evidence that miRNAs play a major role in defining adult tissues.

Figure 5. Biological Validation of the miRNA Array System. Heat map of miRNA expression from 26 normal human tissues. Each sample was hybridized on the array against a pool of all samples. Red indicates that the miRNA is over-expressed relative to sample pool; green indicates that it is under-expressed relative to the sample pool. Hierarchical clustering (right) shows that miRNA expression profiles are similar between related tissues and distinct between unrelated tissues.


The mirVana miRNA array procedure was sensitive, specific, and accurate enough to detect these similarities and differences between adult tissues, providing the opportunity to study the subtle and not so subtle differences between other, more interesting samples.


Scientific Contributors
Jaclyn Shingara, Kerri Keiger, Jeffrey Shelton, Ila Wolf, Emmanu
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