Navigation Links
Getting Started with MicroRNA Research

Illumination of a Critical Regulation Pathway of Protein Expression


MicroRNAs (miRNAs) are a recently identified class of cellular RNAs that regulate protein expression at the translational level. The active, mature miRNAs are 1724 base, single-stranded RNA molecules expressed in eukaryotic cells and are known to affect the translation or stability of target messenger RNAs. Each microRNA is believed to regulate multiple genes, with predictions that greater than one third of all human genes may be regulated by miRNA molecules [1].

Genes encoding approximately 230 miRNAs have already been identified in mammals [2]. Interestingly, more than 90% of the miRNAs are completely conserved among species, suggesting that these molecules are sensitive to small sequence changes and are potentially under extraordinary selection pressure. Here, we provide a general overview for analyzing miRNAs and describe some of the specialized tools that can help assess miRNA expression, function, and targets.

MicroRNAs (miRNAs) are highly conserved regulatory molecules expressed in eukaryotic cells. Data recently published in Cell suggest that the expression of certain genes can be more dependent on the levels of regulatory miRNAs than on the levels of messenger RNAs that encode the proteins [3]. MicroRNAs function through a mechanism similar to short interfering RNAs (siRNAs) in that both of these types of small, single-stranded RNA molecules target specific messenger RNA tra
'"/>

Source:


Page: All 1 2 3 4 5 6 7 8 9

Related biology technology :

1. Novel MicroRNA Array Technology for Sensitive miRNA Profiling
2. MicroRNA Profiling by Array Analysis Reveals Critical BioMarkers
3. The DIG System Nonradioactive Automated High-Throughput In Situ Hybridization: a Powerful Tool for Functional Genomics Research
4. Quantitation of the Protein MIA as a Marker for Chondrocytes in Research Samples
5. Control Your siRNA Research
6. Monitoring Microbial Populations Using Real-Time qPCR on the MJ Research Opticon 2 System
7. Proteomics in Bladder Cancer Research: Protein Profiling of Bladder Squamous Cell Carcinomas, Rev C
8. Research Organics
9. A Robust LC/MS/MS Method for the Quantitation of Very Long Chain Fatty Acids for Research into the Characterization of Peroxisomal Disorders
10. A new LC/MS/MS Research Method for Rapid Quantitation of Five Immunosuppressant Drugs, including Mycophenolic Acid (MPA)
11. Research Tools for Analysis of ZAP-70
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Getting Started with MicroRNA Research

(Date:12/24/2014)... 23, 2014 Pipette.com announces their ... followers can submit their #HolidayInTheLab pictures for a chance ... mates. , For those struggling to think of a ... Holiday in the Lab Contest provides the ideal holiday ... to send pictures of their chemistree, holiday sweaters, ...
(Date:12/24/2014)... -- Rock Creek Pharmaceuticals, Inc., (NASDAQ: RCPI ) ... Application (CTA) with the United Kingdom,s ... approval to initiate clinical trials for the continued development ... on the Company receiving CTA regulatory approval, the Company ... the safety, tolerability and dose escalation of Anatabine Citrate ...
(Date:12/22/2014)... 22, 2014  Alternative Energy & Environmental Solutions, ... signed a letter of intent to acquire BioTechPharma ... patented a nanotechnology-based development platform used to create ... rapid on-site collection and testing to identify infectious ... in an immediate, non-invasive and cost-effective manner. ...
(Date:12/22/2014)... (PRWEB) December 22, 2014 Fertility Associates ... Donor Egg Bank USA , a network of more ... Through this partnership, patients have fast access to a ... vitro fertilization, IVF . Fertility Associates of Memphis is ... this fertility treatment option. , Dr. William Kutteh ...
Breaking Biology Technology:Major Pipette Distributor Pipette.com Announces their Holiday in the Lab Contest 2Rock Creek Pharmaceuticals Files Clinical Trial Application in the UK for Clinical Trials of Anatabine Citrate Formulations 2Rock Creek Pharmaceuticals Files Clinical Trial Application in the UK for Clinical Trials of Anatabine Citrate Formulations 3ALNE Announces Intention To Acquire BioTechPharma 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3
... Same Quarter Last Year - ... - FY08 Revenue Guidance Raised - - Conference ... MINNEAPOLIS, Feb. 11 Uroplasty, Inc. (Amex:,UPI), a medical device company that ... reported record net sales of $3.7 million for the third quarter of,fiscal ...
... Anesiva,Inc. (Nasdaq: ANSV ) announced today the appointment ... Mr. Janney previously served on Anesiva,s,board from November 2000 ... the merger of Anesiva and AlgoRx Pharmaceuticals., "Dan ... directors,and we are very pleased to welcome him back, ...
... INDIANAPOLIS, Feb. 8 Semafore Pharmaceuticals Inc.,today announced ... and Ullrich Schwertschlag, M.D., Ph.D., chief medical officer,will ... programs at,2:45 p.m. EST on Wednesday, Feb. 13, ... New York City., The update will include ...
Cached Biology Technology:Uroplasty Reports Record Sales for Third Fiscal Quarter and Nine Months Ended December 31, 2007 2Uroplasty Reports Record Sales for Third Fiscal Quarter and Nine Months Ended December 31, 2007 3Uroplasty Reports Record Sales for Third Fiscal Quarter and Nine Months Ended December 31, 2007 4Uroplasty Reports Record Sales for Third Fiscal Quarter and Nine Months Ended December 31, 2007 5Uroplasty Reports Record Sales for Third Fiscal Quarter and Nine Months Ended December 31, 2007 6Uroplasty Reports Record Sales for Third Fiscal Quarter and Nine Months Ended December 31, 2007 7Uroplasty Reports Record Sales for Third Fiscal Quarter and Nine Months Ended December 31, 2007 8Uroplasty Reports Record Sales for Third Fiscal Quarter and Nine Months Ended December 31, 2007 9Uroplasty Reports Record Sales for Third Fiscal Quarter and Nine Months Ended December 31, 2007 10Anesiva Appoints Daniel Janney to Board of Directors 2Anesiva Appoints Daniel Janney to Board of Directors 3Semafore to Present at BIO CEO & Investor Conference 2
(Date:12/5/2014)... Calif. , Dec. 4, 2014 ... has boosted investments in new testing and inspection ... also given rise to a range of innovative ... the requirements of Generation Y, which is generally ... As a result, product development strategies of test ...
(Date:12/3/2014)... Calif. , Dec. 2, 2014   ... globally deployed, innovative test solutions for military, aerospace, ... newest version of its successful TS-900 PXI ... performance and features of high-end systems to customers ... outstanding value compared to traditional ATE. ...
(Date:11/21/2014)... Nov. 19, 2014  Earlier this year Donald ... College, and one of the most prolific inventors in ... are transmitted from Smartphones to third party agencies. Spector ... has one of the earliest known patents in this ... in the military, child care, elder care and hospital ...
Breaking Biology News(10 mins):Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 3Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 4Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 2Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 2Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 4
... , ,People,s moral responses to similar situations change as ... University of Chicago that combined brain scanning, eye-tracking and ... morally laden scenarios. Both preschool children and adults ... assessing whether a perpetrator had done something wrong. Nonetheless, ...
... expensive sole fillets or cod caught in the North Sea ... examples of types of fraud in the fisheries sector. A ... based on genetics, genomics, chemistry and forensics - can provide ... fish product come from.where was this fish caught.is it wild ...
... infects people with cystic fibrosis could help combat other ... Warwick Universities. Continuous use of existing antibiotics means ... all over the world. New antibiotics are urgently needed ... the MRSA superbug. Now a surprising source ...
Cached Biology News:Changes in brain circuitry play role in moral sensitivity as people grow up 2Changes in brain circuitry play role in moral sensitivity as people grow up 3What fish is on your plate? 2Cystic fibrosis bacteria could help fight back against antibiotic resistance 2
... Proteolytic degradation is critical to ... short-lived and regulatory proteins as important ... cellular metabolism, heat shock and stress ... surface receptors and ion channels, cell ...
... degradation is critical to the maintenance ... regulatory proteins as important and diverse ... heat shock and stress response, antigen ... and ion channels, cell cycle regulation, ...
Each Yeast-GFP clone represents an individual S. cerevisiae strain containing an open reading frame with a C-terminal Aequorea Victoria GFP (S65T) fusion tag....
... can be used for the identification of potential ... renal and other diseases. Due to the fact ... amounts, it provides an attractive alternative to blood ... The ProteoSpin Urine Protein Concentration Micro Kit ...
Biology Products: