Navigation Links
FluoroMax multiwavelength capability


Introduction
Simultaneously monitoring the levels of relevant metabolites and cell parameters is necessary to properly assess the effectiveness of drugs on living cells. The FLUOROMAX spectrofluorometer allows the user to monitor up to eight wavelength-pairs of emission and excitation wavelengths. Coupling this capability with the proper probes can produce a real-time analysis of unfolding biological processes.


Results
One research application that used simultaneous observation of multiple wavelength-pairs was performed by M. Kimura, et al., at the University of Medicine and Dentistry of New Jersey. 1 Their evaluation of Thapsigargin, a hypertensive drug, was performed on a FLUOROMAX spectrofluorometer. The results demonstrated that the effect of the drug in human platelets was not limited to the elevation of the Ca2+ but produced substantial changes in the overall ionic balance.

Figure 1 shows a sample screen display taken from DATAMAX (FLUOROMAX software for Windows). Note how DATAMAX makes the monitoring of up to eight wavelengthpairs a simple matter of selection.


Conclusion
FLUOROMAX, with DATAMAX software, allows the user to monitor wavelengthpairs to characterize processes in living cells and other biological systems. The measurement is feasible in real time because of the FLUOROMAX spectrofluorometers ability to scan rapidly (up to 200 nm s1).


1 Kimura, M.; et al. J. Physiol. 1993, 494, 113.


back to top
'"/>

Source:


Page: All 1

Related biology technology :

1. Photoluminescence Spectroscopy of Quantum Dots, monitored by the Spex FluoroMax
2. Near IR capability of the FluoroLog
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: FluoroMax multiwavelength capability

(Date:7/25/2008)...Newswire/ -- BioTrends Research Group, Inc.,releas...M) publication, a,syndicated report offering compr...ia and bone and mineral metabolism in Chronic Kidn... information from 182 US,Nephrologists -- data wer...ne 2008., In the renal anemia market, while the u...
(Date:7/25/2008)...X, CALGARY, July 25 / Resv...X:RVX) is pleased to announce effective,immediatel...irectors. On,the subject of her appointment Jan Gr...xciting opportunity for me. The Company has done a...linical trials. I expect the next,foreseeable futu...
(Date:7/25/2008)...swire-FirstCall/ -- Caraco Pharmaceutical,Laborato...first quarter of,Fiscal 2009, ended June 30, 2008,...or the corresponding period of Fiscal 2008. This r...er of Fiscal 2008. Pre-tax income grew,to $14.6 mi...ared to a,pre-tax income of $9.6 million during th...
(Date:7/25/2008)...25 /- REvolution Computing will,lead ...R product at the,upcoming BioC 2008 conference in ... REvolution Computing Director of Community, Dr. D... Training Manager, and Martin Morgan of,the Fred H...ting,s BioC lab,will introduce participants to the...
Breaking Biology Technology:BioTrends Releases Quarterly TreatmentTrends(TM): Nephrology Report Highlighting Market Trends for Renal Anemia, Hyperphosphatemia, and Secondary Hyperparathyroidism 2BioTrends Releases Quarterly TreatmentTrends(TM): Nephrology Report Highlighting Market Trends for Renal Anemia, Hyperphosphatemia, and Secondary Hyperparathyroidism 3Jan Gray Joins Resverlogix Board of Directors 2Caraco Pharmaceutical Laboratories, Ltd. Reports Results for the First Quarter of Fiscal Year 2009 2Caraco Pharmaceutical Laboratories, Ltd. Reports Results for the First Quarter of Fiscal Year 2009 3Caraco Pharmaceutical Laboratories, Ltd. Reports Results for the First Quarter of Fiscal Year 2009 4Caraco Pharmaceutical Laboratories, Ltd. Reports Results for the First Quarter of Fiscal Year 2009 5Caraco Pharmaceutical Laboratories, Ltd. Reports Results for the First Quarter of Fiscal Year 2009 6Caraco Pharmaceutical Laboratories, Ltd. Reports Results for the First Quarter of Fiscal Year 2009 7REvolution Computing Offers Hands-On Tutorial of NWS Parallel Computing Environment at BioC 2008 2
...F 1 • GPCR • receptor binding assa..., , In the mammalian brain, the cor...s four CRF-related peptides (CRF and urocortin 1, ...ubtypes (CRF 1 and CRF 2 , which includes CRF 2 ...ubtypes are positively coupled to adenylyl cyclase...
...minescence • BRET 2 • LEADseeker &... , Competitive pressure is forcing organiz...t. Yet accuracy and sensitivity remain vital conce...escence cell-based assays. LEADseeker™ Multi...e demands by combining excellent detection with th...
...f key importance to many areas of drug discovery. ...the opportunity to discover new therapeutic target...ugs and targets in other therapeutic areas must be... <P ,>The Cell Proliferation Fluorescence Kit... to quantitate cell proliferation, study the regul...
... and J. Flensburg , GE Healthcare, Uppsal...thod was developed to analyse phosphopeptides in m... separated by strong cation exchange chromatograph... (RPC) using Ettan MDLC. The detection was perform...phoric acid to selectively detect the phosphorylat...
Other Biology Technology:Development of a CRF1 neuropeptide receptor binding assay using LEADseeker Multimodality Imaging System 2Development of a CRF1 neuropeptide receptor binding assay using LEADseeker Multimodality Imaging System 3Use of BRET2 luminescence cell-based assays with LEADseeker Multimodality Imaging System 2Use of BRET2 luminescence cell-based assays with LEADseeker Multimodality Imaging System 3Identification of cells in S phase using the Cell Proliferation Fluorescence Kit and IN Cell Analyzer 1000 2Identification of cells in S phase using the Cell Proliferation Fluorescence Kit and IN Cell Analyzer 1000 3Identification of cells in S phase using the Cell Proliferation Fluorescence Kit and IN Cell Analyzer 1000 4Identification of cells in S phase using the Cell Proliferation Fluorescence Kit and IN Cell Analyzer 1000 5Sensitive identification of phosphopeptides in brain tissue using Ettan MDLC and Finnigan LTQ 2Sensitive identification of phosphopeptides in brain tissue using Ettan MDLC and Finnigan LTQ 3Sensitive identification of phosphopeptides in brain tissue using Ettan MDLC and Finnigan LTQ 4
(Date:7/24/2008)...m cells originate in a different part of the brain...ation they can produce new brain cells to replace ...ine scientists has shown. , Evidence strongly sh...n are the ependymal cells that line the ventricles...n the subventricular zone as biologists previously...
(Date:7/24/2008)...a cell, the response to DNA damage determines whet...commit suicide, or grow uncontrollably, a route le...July 25th issue of Cell , scientists at NYU Lango... respond to DNA damage through a process that targ... new pathway for the development of cancer and sug...
(Date:7/24/2008)...e found a molecular link between circadian rhythms...y reveals new possibilities for the treatment of d...aolo Sassone-Corsi, Distinguished Professor and Ch...ified that an essential protein called CLOCK that ...alance with another protein called SIRT1 that modu...
(Date:7/24/2008)...y might tell potential suitors, "I like the way yo...er look. But worms send their valentines via signa...searchers are now cracking, according to a study p...e . , Scientists from the University of Florida...Technology and the U.S. Department of Agriculture ...
Breaking Biology News(10 mins):Adult stem cells activated in mammalian brain 2Adult stem cells activated in mammalian brain 3A new cellular pathway linked to cancer is identified by NYU researchers 2Circadian rhythm-metabolism link discovered 2Mate or hibernate? That's the question worm pheromones answer 2Mate or hibernate? That's the question worm pheromones answer 3IDM Pharma Receives Notification from NASDAQ Relating to Minimum Bid Price 11097 1IDM Pharma Receives Notification from NASDAQ Relating to Minimum Bid Price 11097 2Patient Safety Awareness Week March 2 to March 8 2008 11093 1Patient Safety Awareness Week March 2 to March 8 2008 11093 2Finkelstein Thompson LLP Announces Filing of Securities Fraud Class Action Against CellCyte Genetics Corporation 3045 1Finkelstein Thompson LLP Announces Filing of Securities Fraud Class Action Against CellCyte Genetics Corporation 3045 2Researchers find less invasive highly accurate methods 11088 1Researchers find less invasive highly accurate methods 11088 2Researchers find less invasive highly accurate methods 11088 3Researchers find less invasive highly accurate methods 11088 4
...a which can grow on and ,mop up, smelly compounds ...smelly, highly reactive ,one-carbon, compounds are...containing amino acids in the mouth. , Dr Ann Wood...rted these findings in the August issue of Environ...ic bacteria were isolated from the tongue, tooth p...
...sity School of Medicine have successfully isolated...laboratory and coaxed them into becoming fat, musc...dies to show the ability of a single adult stem ce...day in Stem Cells and Development. , "These cells ...ir and for organs as well," said Anthony Atala, M....
...al engineers has demonstrated for the first time t...ly in one part of the body and use it to repair da...h, which is based on a dramatic departure from the...bed in a paper titled "In vivo engineering of orga...k by the Proceedings of the National Academy of Sc...
...e antibody-producing B cells of the immune system ...kinds of immunity -- innate and acquired, Duke Uni...ed. The division of labor between B-1a and B-1b ce... could contribute to more rational development of ...ies of the immune system, producing antibodies tha...
Other Biology News:Researchers grow stem cells from human skin 2New method shows it is possible to grow bone for grafts within a patient's body 2New method shows it is possible to grow bone for grafts within a patient's body 3Specialized immune-system B cells play double-barreled role 2Specialized immune-system B cells play double-barreled role 3
...y, 1. 1000 V, 400 mA, 100 W maximum.Constant volta...gle-unit increments in settings and read-outs for ...hree protocols.Outstanding choice for non-IEF ultr...stems. Category: Electrophoresis Systems & Standar...
Mouse TrkC Affinity Purified Polyclonal Ab
Immunogen: Full length M32 fusion protein. Storage: -20 C, Avoid Freeze/Thaw Cycles
Normal sheep serum collected from healthy normal sheep
Biology Products: