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Fermentation Cell Culture: University Style

of the steps (e.g., removing the full centrifuge rotor) much easier with two people.

BioPharm: How did you convince the university to fund a fermentation facility?

Stevens: I included the facility costs in my negotiations for my startup funds before coming to the university.

BioPharm: What was the cost of the fermentation facility?

Stevens: Although the cost of all the major equipment was approximately $250,000, a facility build-out will depend on the extent to which the facility is made user-friendly and the needs of the individual investigator.

BioPharm: How long did it take to build the facility?

Stevens: The build-out of the facility took about six months from the time the plans were finalized. A total of about one year was required for all of the planning, building, and equipment testing.

BioPharm: Can you modify the fermentor if your work requires it? Do you envision ever scaling up the volume youre producing? What would scale-up entail with the fermentor?

Stevens: One of the first considerations I addressed with NBS was the modularity of the machine. The design is such that we were able to add options during manufacture and after installation. Based on the scalability of our processes from shakeflask to
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