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Femtogram Sensitivity of the Antipsychotic Drugs Raclopride and Ritanserin Using a Varian 1200L LC/MS/MS

ve in Figure 3 shows the average area of the five replicates plotted against the amount injected.

Ritanserin Five replicates at five different concentration levels were run. FIA injections of Ritanserin at its lowest detectable limit, 10 pg/mL (50 fg on-column), is shown in Figure 4. At a concentration 10 times lower than Raclopride, Ritanserin is easily detected. With a S/N ratio of more than 20:1 at 10 pg/mL, it should be possible to achieve even lower limits of detection for Ritanserin.

Conclusion

The ability to accurately detect low levels of analytes is an essential requirement for many pharmaceutical, toxicological, and clinical applications. The data presented in this application note illustrates that the Varian 1200L triple quadrupole mass spectrometer is capable of achieving very reproducible results at femtogram levels for compounds such as Ritanserin and Raclopride.

References

1. http://www.books.md/R/dic/ritanserin.php

2. http://www.online-medical-dictionary.org/?q=Raclopride

3. Forngren, B.H. Liquid Chromatography-Mass Spectrometry in the Analysis of Radiolabelled Compounds for Positron Emission Tomography. Acta Universitaris Upsaliensis. Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology 586. 56pp. Uppsala. ISBN 91-554-4810-0


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